ID F7IM63_CALJA Unreviewed; 402 AA.
AC F7IM63; U3C4K0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Bone morphogenetic protein 8B preproprotein {ECO:0000313|EMBL:JAB13154.1};
GN Name=BMP8A {ECO:0000313|Ensembl:ENSCJAP00000043157.2};
GN Synonyms=BMP8B {ECO:0000313|EMBL:JAB13154.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000043157.2, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000043157.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB13154.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Hippocampus {ECO:0000313|EMBL:JAB13154.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000043157.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; GAMS01009982; JAB13154.1; -; mRNA.
DR RefSeq; XP_002750685.1; XM_002750639.3.
DR STRING; 9483.ENSCJAP00000043157; -.
DR Ensembl; ENSCJAT00000055362.3; ENSCJAP00000043157.2; ENSCJAG00000002504.4.
DR GeneID; 100398735; -.
DR KEGG; cjc:100398735; -.
DR CTD; 353500; -.
DR GeneTree; ENSGT00940000155272; -.
DR HOGENOM; CLU_020515_4_1_1; -.
DR OMA; DRDIFHQ; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000008225; Chromosome 7.
DR Bgee; ENSCJAG00000002504; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19398; TGF_beta_BMP8; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF119; BONE MORPHOGENETIC PROTEIN 8A-RELATED; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..402
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041157576"
FT DOMAIN 268..402
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 402 AA; 45010 MW; 21EC73BB3FA3A039 CRC64;
MAARPGPLWL LGLALCALGG DGPGPRPPPG CHQRRLGARE RRDVQREILA VLGLPGRPRP
RAPPAASRLP ASAPLFMLDL YHAMASDDDE DGAPPERRLG RADLVMSFVN MVERDRALGH
QEPHWKEFHF DLTQIPAGEA VTAAEFRIYK VPSTHLLNST LHVSMFQVVQ EQFNRESDLF
FLDLQTLGAG DEDWLVLDIT AASDRWLLKR HKDLGLRLYV ETEDGHNVDP GLAGLLGQRA
PRSRQPFVVT FFRASQNPVR TPRAVRPLRR RQPKKTNELP QDSRLPGIFD DVHGSHGRQV
CRRHELYVSF QDLGWLDWII APQGYSAYYC EGECSFPLGS CMNATNHAIL QSLVHLMKPD
TVPKACCAPT KLSATSVLYY DSSNNVILRK KRNMVVKACG CH
//
