ID F7IPX3_CALJA Unreviewed; 398 AA.
AC F7IPX3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Voltage-gated potassium channel subunit beta-2 {ECO:0000256|ARBA:ARBA00013315};
DE AltName: Full=K(+) channel subunit beta-2 {ECO:0000256|ARBA:ARBA00031436};
DE AltName: Full=Kv-beta-2 {ECO:0000256|ARBA:ARBA00032589};
GN Name=KCNAB2 {ECO:0000313|Ensembl:ENSCJAP00000008388.5};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000008388.5, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000008388.5}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000008388.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}. Synapse, synaptosome
CC {ECO:0000256|ARBA:ARBA00034102}.
CC -!- SIMILARITY: Belongs to the shaker potassium channel beta subunit
CC family. {ECO:0000256|ARBA:ARBA00006515}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7IPX3; -.
DR Ensembl; ENSCJAT00000008871.5; ENSCJAP00000008388.5; ENSCJAG00000000086.5.
DR GeneTree; ENSGT00940000157867; -.
DR OMA; YLPWSPL; -.
DR Proteomes; UP000008225; Chromosome 7.
DR Bgee; ENSCJAG00000000086; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd19141; Aldo_ket_red_shaker; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR005983; K_chnl_volt-dep_bsu_KCNAB.
DR InterPro; IPR005399; K_chnl_volt-dep_bsu_KCNAB-rel.
DR InterPro; IPR005401; K_chnl_volt-dep_bsu_KCNAB2.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR NCBIfam; TIGR01293; Kv_beta; 1.
DR PANTHER; PTHR43150; HYPERKINETIC, ISOFORM M; 1.
DR PANTHER; PTHR43150:SF1; VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT BETA-2; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PRINTS; PR01579; KCNAB2CHANEL.
DR PRINTS; PR01577; KCNABCHANNEL.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Synaptosome {ECO:0000256|ARBA:ARBA00022599};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 83..385
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 398 AA; 44004 MW; 3DB951A56425DBBC CRC64;
MQVSFVCSEH SLKGRGPEER LGRPAASSPS IGTRGRFRAV AMVARSLGQL SAQSLPCAGD
TSVKLHGMKY RNLGKSGLRV SCLGLGTWVT FGGQITDEMA EQLMTLAYDN GINLFDTAEV
YAAGKAEVVL GNIIKKKGWR RSSLVITTKI FWGGKAETER GLSRKHIIEG LKASLERLQL
EYVDVVFANR PDPNTPMEET VRAMTHVINQ GMAMYWGTSR WSSMEIMEAY SVARQFNLTP
PICEQAEYHM FQREKVEVQL PELFHKIGVG AMTWSPLACG IVSGKYDSGI PPYSRASLKG
YQWLKDKILS EEGRRQQAKL KELQALAERL GCTLPQLAIA WCLRNEGVSS VLLGASNADQ
LMENIGAIQV LPKLSSSIIH EIDSILGNKP YSKKDYRS
//
