ID F7IQZ7_CALJA Unreviewed; 867 AA.
AC F7IQZ7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Rap guanine nucleotide exchange factor 4 {ECO:0000313|Ensembl:ENSCJAP00000014289.3};
GN Name=RAPGEF4 {ECO:0000313|Ensembl:ENSCJAP00000014289.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000014289.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000014289.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000014289.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7IQZ7; -.
DR Ensembl; ENSCJAT00000015055.5; ENSCJAP00000014289.3; ENSCJAG00000007525.5.
DR GeneTree; ENSGT00940000156075; -.
DR Proteomes; UP000008225; Chromosome 6.
DR Bgee; ENSCJAG00000007525; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd04437; DEP_Epac; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.8.1240; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF175; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 72..147
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 212..313
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 352..490
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 628..865
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 867 AA; 99438 MW; 6BF10F747260E05E CRC64;
MLYKKYRQYM AGLLAPPYGV METGSNNDRI PDKENTPLIE PHVPLRPANT ITKVPSEKIL
KAGKILRNAI LSRAPHMIRD RKYHLKTYRQ CCVGTELVDW MMQQTPCVHS RTQAVGMWQV
LLEDGVLNHV DQEHHFQDKY LFYRFLDDEH EDAPLPTEEE KKECDEELQD TMLLLSQMGP
DAHMRMILRK PPGQRTVDDL EIIYEELLHI KALSHLSTTV KRELAGVLIF ESHAKGGTVL
FNQGEEGTSW YIILKGSVNV VIYGKGVVCT LHEGDDFGKL ALVNDAPRAA SIVLREDNCH
FLRVDKEDFN RILRDVEANT VRLKEHDQDV LVLEKVPAGN RASNQGNSQP QQKYTVMSGT
PEKILEHFLE TIRLEASLNE ATDSVLNDFI MMHCVFMPNT QLCPALVAHY HAQASQGTEQ
EKMDYALNNK RRVIRLVLQW AAMYGDLLQE DDVSMAFLEE FYVSVSDDAR MIAALKEQLP
ELEKIVKQIS EDAKAPQKKH KVLLQQFNTG DERAQKRQPI RGSDEVLFKV YCMDHTYTTI
RVPVAASVKE VISAVADKLG SGEGLIIVKM SSGGEKVVLK PNDVSVFTTL TINGRLFACP
REQFDSLTPL PEQEGPTVGT VGTFELMSSK DLAYQMTIYD WELFNCVHEL ELIYHTFGRH
NFKKTTANLD LFLRRFNEIQ FWVVTEICLC SQLSKRVQLL KKFIKIAAHC KEYKNLNSFF
AIVMGLSNVA VSRLALTWEK LPSKFKKFYA EFESLMDPSR NHRAYRLTIA KLEPPLIPFM
PLLIKDMTFT HEGNKTFIDN LVNFEKMRMI ANTARTVRYY RSQPFNPDAA QANKNHQDVR
SYVRQLNVID NQRTLSQMSH RLEPRRP
//
