ID F7ISK2_CALJA Unreviewed; 719 AA.
AC F7ISK2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Hook microtubule tethering protein 2 {ECO:0000313|Ensembl:ENSCJAP00000009132.3};
GN Name=HOOK2 {ECO:0000313|Ensembl:ENSCJAP00000009132.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000009132.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000009132.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000009132.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the hook family.
CC {ECO:0000256|ARBA:ARBA00006946}.
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DR AlphaFoldDB; F7ISK2; -.
DR STRING; 9483.ENSCJAP00000009132; -.
DR Ensembl; ENSCJAT00000009650.4; ENSCJAP00000009132.3; ENSCJAG00000004942.4.
DR GeneTree; ENSGT00940000160152; -.
DR InParanoid; F7ISK2; -.
DR OMA; RGQLDTY; -.
DR Proteomes; UP000008225; Chromosome 22.
DR Bgee; ENSCJAG00000004942; Expressed in kidney and 6 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0070695; C:FHF complex; IEA:Ensembl.
DR GO; GO:0030897; C:HOPS complex; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:InterPro.
DR GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IEA:InterPro.
DR GO; GO:0045022; P:early endosome to late endosome transport; IEA:Ensembl.
DR GO; GO:0007032; P:endosome organization; IEA:Ensembl.
DR GO; GO:0008333; P:endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:0007040; P:lysosome organization; IEA:Ensembl.
DR GO; GO:1905719; P:protein localization to perinuclear region of cytoplasm; IEA:Ensembl.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR008636; Hook_C.
DR InterPro; IPR043936; HOOK_N.
DR PANTHER; PTHR18947; HOOK PROTEINS; 1.
DR PANTHER; PTHR18947:SF37; PROTEIN HOOK HOMOLOG 2; 1.
DR Pfam; PF05622; HOOK; 1.
DR Pfam; PF19047; HOOK_N; 1.
DR SUPFAM; SSF116907; Hook domain; 1.
DR PROSITE; PS50021; CH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 6..122
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 698..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 180..427
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 475..606
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 719 AA; 83151 MW; D895495BD6C2CBF1 CRC64;
MSVDKAELCG SLLTWLQTFH VPSPSASPQD LSSGLAIAYA LNQIDPSWFN EAWLQGISED
PGPNWKLKVS NLKTVLRSLV EYSQDVLAHP VSEEHLPDVG LIGEFSDPAE LGKLLQLVLG
CAISCEKKQE HIQRIMTLEE SVQHVVMEAI QELMTKDNPD SLSPETYGNF DTQSRRYYFL
SEEAEEGDEL QQRCLDLERQ LMLLSEEKQS LAQENAALRE RVVQPEGEGT PGLTAKKLLL
LQSQLEQLQE ENFRLESGRE DERLRCAELE REVAELQHRN QALTSLAQEA QALKDEMDEL
RQSSERAGQL EATLTSCRRR LGELRELRRQ VRQLEERNAG HAERTRQLEE ELRRAGSLRV
QLEAQRRQVQ ELQGQRQEEA MKAEKWLFEC RNLEEKYESV TKEKERLLAE RDSLREANEE
LRCAQLQPRG LTQADLSMDP TSPAVDNLAA EILPAELRET LLRLQLENKR LCRQEAADRE
RQEELQRHLE EANRARHGLE TQHRLNQQQL SELRAQVEDL QKSLQEQGGK TEDAISILLK
RKLEEHLQKL HEADLELQRK REYIEELEPP TDSSTARRIE ELQHSLQKKD ADLRAMEERY
RRYVDKAHMV MQTLEPKQRP AVGAPPDLHT LRTKLRERDV RIRHLEMDFE KSRSQREQEE
KLLISAWYNM GMALQQRAGE ERAPAHAQSF LAQQRLATNA RRGPLGRLAS LSLRPTDKH
//
