ID F7J1H2_9NEOB Unreviewed; 247 AA.
AC F7J1H2;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:BAK41105.1};
OS Chaperina fusca (brown thorny frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Microhyloidea; Microhylidae; Microhylinae;
OC Chaperina.
OX NCBI_TaxID=377263 {ECO:0000313|EMBL:BAK41105.1};
RN [1] {ECO:0000313|EMBL:BAK41105.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21689462; DOI=10.1186/1471-2148-11-175;
RA Kurabayashi A., Matsui M., Belabut D.M., Yong H.-S., Ahmad N., Sudin A.,
RA Kuramoto M., Hamidy A., Sumida M.;
RT "From Antarctica or Asia? New colonization scenario for Australian-New
RT Guinean narrow mouth toads suggested from the findings on a mysterious
RT genus Gastrophrynoides.";
RL BMC Evol. Biol. 11:175-175(2011).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; AB611868; BAK41105.1; -; Genomic_DNA.
DR AlphaFoldDB; F7J1H2; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU364086};
KW Signal {ECO:0000256|RuleBase:RU364086}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|RuleBase:RU364086"
FT CHAIN 18..247
FT /note="Brain-derived neurotrophic factor"
FT /evidence="ECO:0000256|RuleBase:RU364086"
FT /id="PRO_5010897306"
FT DOMAIN 133..240
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 141..208
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 186..237
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 196..239
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAK41105.1"
FT NON_TER 247
FT /evidence="ECO:0000313|EMBL:BAK41105.1"
SQ SEQUENCE 247 AA; 27822 MW; D05E2514DDB6C01C CRC64;
TILFLTMVIS YLSCMKAAPM KEANVRGQSG LAYPGLRTHG TLENIGGPIG GSRGGGLPSL
SDTFEHVIEE LLEEEQTIRQ SEENKDSDLY TSRVMLSTQV PLEPPLLFLL EEYKNYLDAA
NMSMRVRRHS DPARRGELSV CDSISEWVTA ADKKTAVDMA GQTVTVLEKV PVPKGQLKQY
FYETKCNPMG YMKEGCRGID KRYWNSQCRT TQSYVRALTM DSKKKVGWRF IRIDTTCVCT
LTIKRGR
//
