ID F7J7V5_9HIV1 Unreviewed; 365 AA.
AC F7J7V5;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Polyprotein {ECO:0000313|EMBL:BAK40705.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:BAK40705.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:BAK40705.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:BAK40705.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C04-5555-6242-1 {ECO:0000313|EMBL:BAK40705.1};
RX PubMed=17194486; DOI=10.1016/j.antiviral.2006.11.012;
RA Gatanaga H., Ibe S., Matsuda M., Yoshida S., Asagi T., Kondo M.,
RA Sadamasu K., Tsukada H., Masakane A., Mori H., Takata N., Minami R.,
RA Tateyama M., Koike T., Itoh T., Imai M., Nagashima M., Gejyo F., Ueda M.,
RA Hamaguchi M., Kojima Y., Shirasaka T., Kimura A., Yamamoto M., Fujita J.,
RA Oka S., Sugiura W.;
RT "Drug-resistant HIV-1 prevalence in patients newly diagnosed with HIV/AIDS
RT in Japan.";
RL Antiviral Res. 75:75-82(2007).
RN [2] {ECO:0000313|EMBL:BAK40705.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C04-5555-6242-1 {ECO:0000313|EMBL:BAK40705.1};
RX PubMed=20692295; DOI=10.1016/j.antiviral.2010.07.008;
RA Hattori J., Shiino T., Gatanaga H., Yoshida S., Watanabe D., Minami R.,
RA Sadamasu K., Kondo M., Mori H., Ueda M., Tateyama M., Ueda A., Kato S.,
RA Itoh T., Oie M., Takata N., Hayashida T., Nagashima M., Matsuda M., Ibe S.,
RA Ota Y., Sasaki S., Ishigatsubo Y., Tanabe Y., Koga I., Kojima Y.,
RA Yamamoto M., Fujita J., Yokomaku Y., Koike T., Shirasaka T., Oka S.,
RA Sugiura W.;
RT "Trends in transmitted drug-resistant HIV-1 and demographic characteristics
RT of newly diagnosed patients: nationwide surveillance from 2003 to 2008 in
RT Japan.";
RL Antiviral Res. 88:72-79(2010).
RN [3] {ECO:0000313|EMBL:BAK40705.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C04-5555-6242-1 {ECO:0000313|EMBL:BAK40705.1};
RA Matsuda M., Shiino T., Takata N., Kimura A., Tateyama M., Fujita J.,
RA Sadamasu K., Nagasima M., Sugiura W.;
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endohydrolysis of RNA in RNA/DNA hybrids. Three different
CC cleavage modes: 1. sequence-specific internal cleavage of RNA. Human
CC immunodeficiency virus type 1 and Moloney murine leukemia virus
CC enzymes prefer to cleave the RNA strand one nucleotide away from the
CC RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides
CC from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides
CC away from the primer terminus.; EC=3.1.26.13;
CC Evidence={ECO:0000256|ARBA:ARBA00023415};
CC -!- SIMILARITY: Belongs to the retroviral Pol polyprotein family.
CC {ECO:0000256|RuleBase:RU004064}.
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DR EMBL; AB640443; BAK40705.1; -; Genomic_RNA.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR CDD; cd05482; HIV_retropepsin_like; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001995; Peptidase_A2_cat.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR034170; Retropepsin-like_cat_dom.
DR InterPro; IPR018061; Retropepsins.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR010661; RVT_thumb.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00077; RVP; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF06817; RVT_thumb; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50175; ASP_PROT_RETROV; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750,
KW ECO:0000256|RuleBase:RU004064};
KW DNA integration {ECO:0000256|ARBA:ARBA00023195};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004064};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|RuleBase:RU004064};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023195};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 20..89
FT /note="Peptidase A2"
FT /evidence="ECO:0000259|PROSITE:PS50175"
FT DOMAIN 143..333
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAK40705.1"
FT NON_TER 365
FT /evidence="ECO:0000313|EMBL:BAK40705.1"
SQ SEQUENCE 365 AA; 41764 MW; BEA6E9FB57BA89EA CRC64;
PQITLWQRPL VTIKVGGQLK EALLDTGADD TVLEEMNLPG KWKPKMIGGI GGFIKVRQYD
QIAIEICGHK AIGTVLVGPT PVNIIGRNLL TQIGCTLNFP ISPIETVPVK LKPGMDGPKV
KQWPLTEEKI KALIEICTEM EKEGKISKIG PENPYNTPVF AIKKKDSTKW RKLVDFRELN
KRTQDFWEVQ LGIPHPAGLK KKKSVTVLDV GDAYFSVPLD KDFRKYTAFT IPSLNNETPG
IRYQYNVLPQ GWKGSPAIFQ CSMTKILEPF RKQNPDIVIY QYMDDLYVGS DLEIEQHRTK
IEELRQHLLR WGFTTPDKKH QKEPPFLWMG YELHPDKWTV QPIVLPEKDS WTVNDIQKLV
GKLNW
//
