ID F7JQR4_9FIRM Unreviewed; 1012 AA.
AC F7JQR4;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Beta-galactosidase {ECO:0000256|ARBA:ARBA00013303, ECO:0000256|RuleBase:RU361154};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756, ECO:0000256|RuleBase:RU361154};
DE AltName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230, ECO:0000256|RuleBase:RU361154};
GN ORFNames=HMPREF0988_02711 {ECO:0000313|EMBL:EGN35591.1};
OS Lachnospiraceae bacterium 1_4_56FAA.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=658655 {ECO:0000313|EMBL:EGN35591.1, ECO:0000313|Proteomes:UP000004289};
RN [1] {ECO:0000313|EMBL:EGN35591.1, ECO:0000313|Proteomes:UP000004289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1_4_56FAA {ECO:0000313|EMBL:EGN35591.1,
RC ECO:0000313|Proteomes:UP000004289};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A.,
RA Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C., Larson L., Lui A.,
RA MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C., Neiman D.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium 1_4_56FAA.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412,
CC ECO:0000256|RuleBase:RU361154};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401, ECO:0000256|RuleBase:RU361154}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGN35591.1}.
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DR EMBL; ACTN01000017; EGN35591.1; -; Genomic_DNA.
DR AlphaFoldDB; F7JQR4; -.
DR STRING; 658655.HMPREF0988_02711; -.
DR PATRIC; fig|658655.3.peg.2765; -.
DR eggNOG; COG3250; Bacteria.
DR HOGENOM; CLU_002346_0_2_9; -.
DR OrthoDB; 9762066at2; -.
DR Proteomes; UP000004289; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR004199; B-gal_small/dom_5.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR023230; Glyco_hydro_2_CS.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032312; LacZ_4.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF02929; Bgal_small_N; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR Pfam; PF16353; LacZ_4; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SMART; SM01038; Bgal_small_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00719; GLYCOSYL_HYDROL_F2_1; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361154};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361154};
KW Reference proteome {ECO:0000313|Proteomes:UP000004289}.
FT DOMAIN 739..1007
FT /note="Beta galactosidase small chain/"
FT /evidence="ECO:0000259|SMART:SM01038"
SQ SEQUENCE 1012 AA; 117606 MW; 0BBB4DAEE6068084 CRC64;
MIVPRYYENL SVLHENTMPA RAYYIPSSKR MDNLVEHREE SDRMQLLNGT WKFQYFNSIY
DIQDSFFEKN YDTENFDEIQ VPSVWQMAGY DTHQYTNIRY PFPFDPPYVP QDIPCGAYVH
TFEYSRDEKA PKSFLNFEGV DSCFYVWLNG SYIGYSQVSH MTSEFDVTGV LQDGTNTVAV
LVMKWCDGSY LEDQDKFRMS GIFRDVYILK RPKQAISDYH IKTRIEDMLA KVEIEMKFYS
PLNVKISIED RNGAVVALGS IAKKGTAVLE IASPELWNTE NPYLYKLILE TENEVIVDHI
ALRKIEIKDQ VIYLNGQKIK FRGVNRHDSD PVTGFTINPE QITTDLTLMK QHNFNAIRSS
HYPNAPFFYE MCDKYGFMVI DEADIEAHGP FMIYRKEDTD YNRFKRWNEK IADDPVWEEA
IVDRVKLMVE RDKNRFCIVM WSMGNESAYG CNFEKALEWT KNFDPDRITQ YESARYRNYD
ETYDYSNLDV YSRMYPALSE IQEYLDKDGS KPFLLVEYCH SMGNGPGDFE DYFQMIQDND
KMCGGFVWEW CDHAIAHGTA ESGKTIYAYG GDHGEEIHDG NFCMDGLVYP DRTVHTGLLE
YKNVYRPARV ISYDKESGEL VLHNYMDFDN LKDYVKISYE LTQDGFVISK GILPEFSVAP
HGEEKTNLKI NVPVNGKCYL KLIYHLKKEV PLLDEDHILG FDEIEVSKDD AKCKLAEKWL
QKTAVGSELQ VNENDTQIHI KGREFAYTID KRTALFTEMK FAGREYLNHP MELNIWRAPT
DNDMYIKSEW KKAHYDKAYT RAYTTEVVQG KHGVKITSHA SVVAETVQKI LDVTITWKIE
AAGKIDADIA VTKDDEFPDL PRFGVRMFLD KKLSATRYFG MGPQESYCDK HQAASHGLYQ
ANVDDLHEDY IRPQENGSHY DCEYVELNNS RYGIVVSAEN AFSFNASYYT QEELEEKTHN
YELIESDSVV FCVDYALNGI GSNSCGPVVL EQYRFDDVLF RFQFTLIPYI KG
//
