ID F7KL10_9FIRM Unreviewed; 822 AA.
AC F7KL10;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Glycoside hydrolase family 38 central domain-containing protein {ECO:0000259|SMART:SM00872};
GN ORFNames=HMPREF0994_06539 {ECO:0000313|EMBL:EGN47258.1};
OS Lachnospiraceae bacterium 3_1_57FAA_CT1.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=658086 {ECO:0000313|EMBL:EGN47258.1, ECO:0000313|Proteomes:UP000003336};
RN [1] {ECO:0000313|Proteomes:UP000003336}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3_1_57FAA_CT1 {ECO:0000313|Proteomes:UP000003336};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A.,
RA Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C., Larson L., Lui A.,
RA MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C., Neiman D.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EGN47258.1, ECO:0000313|Proteomes:UP000003336}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3_1_57FAA_CT1 {ECO:0000313|EMBL:EGN47258.1,
RC ECO:0000313|Proteomes:UP000003336};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA Allen-Vercoe E., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M.,
RA Haas B., Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M.,
RA Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A., Larimer J.,
RA McCowan C., Murphy C., Pearson M., Poon T.W., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGN47258.1}.
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DR EMBL; ACTP02000021; EGN47258.1; -; Genomic_DNA.
DR AlphaFoldDB; F7KL10; -.
DR STRING; 658086.HMPREF0994_06539; -.
DR eggNOG; COG0383; Bacteria.
DR HOGENOM; CLU_003442_1_1_9; -.
DR Proteomes; UP000003336; Unassembled WGS sequence.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000003336}.
FT DOMAIN 271..345
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 822 AA; 93315 MW; 04E01F5783779AD5 CRC64;
MRDNKTLYLV CNAHLDLVWQ WEWHESLAEA LSTFRIAAAF CETYDGFIFN HNEAKLYQWI
EEYDPPLFQK IQDLVQKGKW HIMGGWYLQP DCVMSSGESI FRQMEKGLNY FREKFGCRPR
TAINVDSFGH DRGLVQLLRK SGYTSYLVGR PSLEVCKAPG PDFLWEGYDG TCIPVHLAAE
GYNSGLGKVR RKLEYYRRQE GTDNSVLALW GIGNHGGGPS KEDLDEISLL QKEWEKEGVQ
LIHSTPEMYF DSISGSELPL FDREIGPSMP GCYTSQVRIK QTHCLLENML YQTEKLLAAA
EIFTGMEGDW ESLKQAEEIL LFNEFHDILP GTSVQRAEDA ALREMGGAIS LLEKEKTRAF
MHLCRQTEKL EPGVIPIFAC NPHPWPVKAV LECEFQLQDQ GWDYTYTDFE VRYQGEVIPS
QLEKEGSSIP LDWRKRLVFM ADIPPFATAA LYAYPKVLTG KPELPQTIES EIRLEGSGGE
LIIDKKSGLI SSYRIDGISL FCPGAARLVV IADNEDPWGM TVNSFPEIIG EFTPASPEQA
GKICGLDKAI DPVHIIEHGP VRTVVEAIFL YKRSAAIVHY KFQPITNKLD LEIHLQWNEP
NHMVKLSLPT PWKDAECWGQ KMLGRARLYE NGTENVSQKW ISVCNDKLGL TILNQGSYGS
SFENGELRLT LLRSPAYTAH PIDDRIILPQ DRFLSRIDIG ERSFLFSIHG GERECQLNTA
DKEAAVYNEA PFARSYFTNA SKPTAGGNIK IDEEQIQLLC LKRTDAGYLI HLYNSSSQPR
KTRFTFIERE IMVELDPFEL KALHYSQGIL EPCGLITLQD TL
//
