ID F7KSR3_9FIRM Unreviewed; 515 AA.
AC F7KSR3;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=BlaR1 family beta-lactam sensor/signal transducer {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF0993_02045 {ECO:0000313|EMBL:EGN38468.1};
OS Lachnospiraceae bacterium 5_1_57FAA.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=658085 {ECO:0000313|EMBL:EGN38468.1, ECO:0000313|Proteomes:UP000005617};
RN [1] {ECO:0000313|EMBL:EGN38468.1, ECO:0000313|Proteomes:UP000005617}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5_1_57FAA {ECO:0000313|EMBL:EGN38468.1,
RC ECO:0000313|Proteomes:UP000005617};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A.,
RA Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C., Larson L., Lui A.,
RA MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C., Neiman D.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium 5_1_57FAA.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M56 family.
CC {ECO:0000256|ARBA:ARBA00011075}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGN38468.1}.
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DR EMBL; ACTR01000021; EGN38468.1; -; Genomic_DNA.
DR AlphaFoldDB; F7KSR3; -.
DR PATRIC; fig|658085.3.peg.2133; -.
DR HOGENOM; CLU_035412_0_2_9; -.
DR Proteomes; UP000005617; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR CDD; cd07341; M56_BlaR1_MecR1_like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR008756; Peptidase_M56.
DR PANTHER; PTHR34978; POSSIBLE SENSOR-TRANSDUCER PROTEIN BLAR; 1.
DR PANTHER; PTHR34978:SF3; SLR0241 PROTEIN; 1.
DR Pfam; PF05569; Peptidase_M56; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005617};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 33..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..227
FT /note="Peptidase M56"
FT /evidence="ECO:0000259|Pfam:PF05569"
FT DOMAIN 298..510
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 515 AA; 59053 MW; 55484A836ED96FFA CRC64;
MKPLDNAALP TQLGISDFAA SYGSSALNQL NSIFIPIWII GCLITILYFA YNIIKIYSIR
KSAYLISKEN EPDLYRQYSE CLNELRIKRK VSLYASCNMS SPVSYGLLHP KVIIPQDMDI
LLSNEDVRFI FLHELLHYRH KDAALNYITC ILQVIYWFNP FIWYGFRELQ KDREIACDSS
VIHIVGKSQS TNYGYTLIKY AQRMQHNAFL SPLSRLGGEK KVMIQRIKEI ANYKTNTPKQ
RRKSAALLLL ICTIVYCISP LLTVYAAHDV SYDFQSQNVE TMDLSSYFKG TDGTFILYDT
SSGQYQIYNQ ELSTKRISPD STFKIYSGLF ALEEGIIHYD ASNREWDGTT YSFDTWNKDQ
TLATAMQNSV NWYFQNLDIQ LGYQKLYSYY KKISYGNCDL TADINYYWAE SSLKISPVEQ
VMLLSNLLKN KWNFKEENIQ AIKNSLFISN ISIGRLYGKT GTGVVNGQNS NGWFIGFIEH
GERVYCFATN LQNADNATGS TASEITIEIL NSIFS
//
