ID F7L0G6_9FUSO Unreviewed; 724 AA.
AC F7L0G6;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=GTP diphosphokinase {ECO:0000313|EMBL:EGN66969.1};
GN ORFNames=HMPREF0401_01337 {ECO:0000313|EMBL:EGN66969.1};
OS Fusobacterium animalis 11_3_2.
OC Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Fusobacteriaceae;
OC Fusobacterium.
OX NCBI_TaxID=457403 {ECO:0000313|EMBL:EGN66969.1, ECO:0000313|Proteomes:UP000004160};
RN [1] {ECO:0000313|EMBL:EGN66969.1, ECO:0000313|Proteomes:UP000004160}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=11_3_2 {ECO:0000313|EMBL:EGN66969.1,
RC ECO:0000313|Proteomes:UP000004160};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Sibley C.D., White A.P.,
RA Crowley S., Surette M., Strauss J.C., Ambrose C.E., Allen-Vercoe E.,
RA Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A.,
RA Alvarado L., Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z.,
RA Dunbar C., Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P.,
RA Mehta T., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Fusobacterium sp. 11_3_2.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGN66969.1}.
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DR EMBL; ACUO01000019; EGN66969.1; -; Genomic_DNA.
DR RefSeq; WP_005910680.1; NZ_GL945392.1.
DR AlphaFoldDB; F7L0G6; -.
DR PATRIC; fig|457403.8.peg.1351; -.
DR HOGENOM; CLU_012300_3_0_0; -.
DR Proteomes; UP000004160; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:EGN66969.1};
KW Transferase {ECO:0000313|EMBL:EGN66969.1}.
FT DOMAIN 45..142
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 380..443
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 650..724
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 724 AA; 82787 MW; 965911F69FE4A4FA CRC64;
MNYWEQLLDK AKANHLNLDF DKIKLALGFA EESHQGQYRK SGDDYIVHPV EVAKILMDMK
MDTDTIVAGL LHDVVEDTLI PIADIKYNFG DTVATLVDGV TKLKALPNGT KNQAENIRKM
ILAMAENIRV ILIKLADRLH NMRTLKFMKP EKQQSISKET LDIYAPLAHR LGMAKVKSEL
EDIAFSYLHH DEFLEIKRLV DNTKEERKDY IENFIRTMIR TLSELGIKAE VKGRFKHFYS
IYRKMYQKGK DFDDIYDLMG VRVIVEDKAT CYHVLGIVHS QYTPVPGRFK DYIAVPKSNN
YQSIHTTIVG PLGKFIEIQI RTKDMDDIAE EGIAAHWNYK ENKKSSKDDN IYGWLRHIIE
FQNESDSTED FIEGVTGDID RGTVFTFSPK GDIIELPVGA TALDFAFMVH TQVGCKCVGA
KVNGRMVTID HKLKSGDKVE IITSKNSKGP SIDWLDIVVT HGAKGKIRKF LKDENKENVT
KLGKDNLEKE ASKLGMTLKE IENDPTLKKH MEKNNISSLD EFYFYIGEKR SRLDILINKI
KINLEKERAA STLTIEEVLK KKEEKKKEGK NDFGIVIDGV NNTLIRFAKC CTPLPGDEIG
GFVTKLTGIT VHRKDCPNFH AMIEKDPSRE ILVKWDENLI ETKMNKYNFT FTVVLNDRPN
ILMEIVNLIA NHKINITSVN SYEVKKDGDR VIKVKISIEI KGKAEYDYLI SNILKLKDVI
SVER
//
