ID F7NGU2_9FIRM Unreviewed; 386 AA.
AC F7NGU2;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Efflux transporter RND family, MFP subunit {ECO:0000313|EMBL:EGO64673.1};
GN ORFNames=ALO_06418 {ECO:0000313|EMBL:EGO64673.1};
OS Acetonema longum DSM 6540.
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Sporomusaceae;
OC Acetonema.
OX NCBI_TaxID=1009370 {ECO:0000313|EMBL:EGO64673.1, ECO:0000313|Proteomes:UP000003240};
RN [1] {ECO:0000313|EMBL:EGO64673.1, ECO:0000313|Proteomes:UP000003240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6540 {ECO:0000313|EMBL:EGO64673.1,
RC ECO:0000313|Proteomes:UP000003240};
RX PubMed=21673657; DOI=10.1038/emboj.2011.186;
RA Chen S., Beeby M., Murphy G.E., Leadbetter J.R., Hendrixson D.R.,
RA Briegel A., Li Z., Shi J., Tocheva E.I., Muller A., Dobro M.J.,
RA Jensen G.J.;
RT "Structural diversity of bacterial flagellar motors.";
RL EMBO J. 30:2972-2981(2011).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004519}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGO64673.1}.
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DR EMBL; AFGF01000050; EGO64673.1; -; Genomic_DNA.
DR RefSeq; WP_004093952.1; NZ_AFGF01000050.1.
DR AlphaFoldDB; F7NGU2; -.
DR STRING; 1009370.ALO_06418; -.
DR eggNOG; COG0845; Bacteria.
DR OrthoDB; 9801814at2; -.
DR Proteomes; UP000003240; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000003240};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 61..291
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT DOMAIN 292..358
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
SQ SEQUENCE 386 AA; 41058 MW; 39BE6786A9A090B8 CRC64;
MFSVKMIKGC RAGLSAAVTI LILAGCGGPQ EAAQERAVPV KAVKIIQQDV QIANEYAGQI
QAKTEVKIQA RVSGHIMEKM VAGGDMVKAG QPLFRIDSLQ YESSLLSAQA QLAQAEANWE
NSRLDTERYE NLLQQAAIPE QRLTTQKAAE RQNEAVVASY RALVKKAQDD VDSTLVISPI
DGRIDVDDVG VGTFVQAGST TLVTVGSQDP VFVQFNMSEN EYLNLRQVSP DNIADGGWGE
GVTITLSNGA AYPLSGKVTQ VDRGLANNSG TLTLKATLAN PEGILIPGMF ARVKIAGAPI
RNAILVPQRA VQQILDKSLV MVVNAGNQAE PRPVTLGEKV GGFWLVKEGL TADDTVVVEG
LTKVREGAAL DVTVVTPAEL ELSINS
//
