ID F7V545_CLOSS Unreviewed; 548 AA.
AC F7V545;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=PABS domain-containing protein {ECO:0000259|PROSITE:PS51006};
GN OrderedLocusNames=CXIVA_19070 {ECO:0000313|EMBL:BAK47874.1};
OS Clostridium sp. (strain SY8519).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1042156 {ECO:0000313|EMBL:BAK47874.1, ECO:0000313|Proteomes:UP000008937};
RN [1] {ECO:0000313|Proteomes:UP000008937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SY8519 {ECO:0000313|Proteomes:UP000008937};
RX PubMed=21914882; DOI=10.1128/JB.05637-11;
RA Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.;
RT "Complete genomic sequence of the O-desmethylangolensin-producing bacterium
RT Clostridium rRNA cluster XIVa strain SY8519, isolated from adult human
RT intestine.";
RL J. Bacteriol. 193:5568-5569(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the spermidine/spermine synthase family.
CC {ECO:0000256|ARBA:ARBA00007867}.
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DR EMBL; AP012212; BAK47874.1; -; Genomic_DNA.
DR RefSeq; WP_013977835.1; NC_015737.1.
DR AlphaFoldDB; F7V545; -.
DR STRING; 1042156.CXIVA_19070; -.
DR KEGG; cls:CXIVA_19070; -.
DR eggNOG; COG4262; Bacteria.
DR HOGENOM; CLU_008530_1_0_9; -.
DR OrthoDB; 9761985at2; -.
DR Proteomes; UP000008937; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006596; P:polyamine biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR030374; PABS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF037959; MFS_SpdSyn; 1.
DR PANTHER; PTHR43317:SF9; POLYAMINE AMINOPROPYLTRANSFERASE 2; 1.
DR PANTHER; PTHR43317; THERMOSPERMINE SYNTHASE ACAULIS5; 1.
DR Pfam; PF01564; Spermine_synth; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51006; PABS_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Polyamine biosynthesis {ECO:0000256|ARBA:ARBA00023115, ECO:0000256|PROSITE-
KW ProRule:PRU00354}; Reference proteome {ECO:0000313|Proteomes:UP000008937};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00354}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 234..466
FT /note="PABS"
FT /evidence="ECO:0000259|PROSITE:PS51006"
FT ACT_SITE 382
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00354"
SQ SEQUENCE 548 AA; 60248 MW; 20D05AA0F5821445 CRC64;
MKTNHRSAPR SENRKNILAH RWYLYLTEFF AGMSVMAVEL GASRLLAPFF SSSQIVWTII
IGTIMIAMAL GNVMGGRWAD RDRNPSRLFF RILIAAVWIG LIPLAGKYLI AAVTGILVIA
VNTNLLIWAA FLTCMVLFVF PLFLLGTVTP SLIRFGVSDL DESGRVAGRL GACNTIGSII
GTFLPTFVTI PAVGTAVTFL IFSGILLALS AVYFFVNGGG KRCLSICCAL FIVSGIFGHT
SNFAFWENHL TYEGESIYNY LQVKDLPDRR ILSTNVLFGV QSVAMKQPGL TGLYYDYALA
APVMAGRKDP DILVLGMGTG TFAASCRRYF PQASISGVEI DQKITHLARR YFHLPSSIPV
TAYDGRAYLN ADSGTYDVIM VDAYQDITIP FQMSSREFFT SVRNHLKKNG VMIVNMNMHG
TDAGKKSDDI TAYLTDTIAS VFPDCVTVDV ADTTNRELFA GTGSPGTLSR SLRQNISSLT
ADTDLTELLR KEAPRLTAVQ AGDRILTDDR APVELIGMRT IDTLIQEELR TYKKIYREKG
LRGLLADL
//
