ID F7V605_CLOSS Unreviewed; 626 AA.
AC F7V605;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=UvrD {ECO:0000313|EMBL:BAK48184.1};
GN OrderedLocusNames=CXIVA_22170 {ECO:0000313|EMBL:BAK48184.1};
OS Clostridium sp. (strain SY8519).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1042156 {ECO:0000313|EMBL:BAK48184.1, ECO:0000313|Proteomes:UP000008937};
RN [1] {ECO:0000313|Proteomes:UP000008937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SY8519 {ECO:0000313|Proteomes:UP000008937};
RX PubMed=21914882; DOI=10.1128/JB.05637-11;
RA Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.;
RT "Complete genomic sequence of the O-desmethylangolensin-producing bacterium
RT Clostridium rRNA cluster XIVa strain SY8519, isolated from adult human
RT intestine.";
RL J. Bacteriol. 193:5568-5569(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; AP012212; BAK48184.1; -; Genomic_DNA.
DR AlphaFoldDB; F7V605; -.
DR STRING; 1042156.CXIVA_22170; -.
DR KEGG; cls:CXIVA_22170; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_004585_6_1_9; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000008937; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000008937}.
FT DOMAIN 1..275
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 276..540
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 607..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 21..28
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 626 AA; 72916 MW; B5875C419BF9DA31 CRC64;
MIDSCQIRAA RHRDGPMLVI AGPGSGKTTV ITERTRWLIE GCGVPPSEIL VLTFTRAAAG
EMRERFLRMT QGKNYPVCFG TFHAVFFMIL KESFHYSASD ILREEEKYAF FKERLYAHSI
VFDDEHTFIG QLIREISQLK NSGALPETCE SPGMPAETFR RICQEYQEEL RRRHGLDFDD
ILIRCRDLLT EHPEVRSAWQ QRFSYILVDE FQDINPLQYQ IVRMLAEPER NLFLVGDDDQ
SIYRFRGAKP ELMLRVPQDY PDLIRVSLSV NYRSGAAIVS LASQLISRNR ERYEKQIRPG
CRIRDRVFFR QYDSQQMQNL SIIGEIRRLL YQGMPAEEIA VLARTGRQLM LLTQQMDAYS
IPYHSRDHIP DPYHHWIMDD ILCYLRAAVG SCSRSAILRI MNRPNRFLSR DGLPDPEVNW
NRWMAYYRNK NMDWLEGRVR RLQEDLKQLG GMRPYAALIY IRKGIGYEAF LQEYAESHGT
EAEELMDLLD AVTAHAAEYP SLEAWLAAVE RIRKQVRRRP GPCGTEEKGV TVGTYHSSKG
LEFDAVFLPD LNERLIPHKR AVLEVDLEEE RRMLYVAITR ARKRLYLLVP AHIRNKETEP
SRFLKEMNLE NALPSPPRQQ DGEMPG
//
