ID F7XNL9_METZD Unreviewed; 278 AA.
AC F7XNL9;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=F420-dependent methylenetetrahydromethanopterin dehydrogenase {ECO:0000256|ARBA:ARBA00014062, ECO:0000256|HAMAP-Rule:MF_00058};
DE Short=MTD {ECO:0000256|HAMAP-Rule:MF_00058};
DE EC=1.5.98.1 {ECO:0000256|ARBA:ARBA00012904, ECO:0000256|HAMAP-Rule:MF_00058};
DE AltName: Full=Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase {ECO:0000256|ARBA:ARBA00031410, ECO:0000256|HAMAP-Rule:MF_00058};
GN Name=mtd {ECO:0000256|HAMAP-Rule:MF_00058};
GN OrderedLocusNames=Mzhil_0239 {ECO:0000313|EMBL:AEH60116.1};
OS Methanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5)
OS (Methanohalophilus zhilinae).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosalsum.
OX NCBI_TaxID=679901 {ECO:0000313|EMBL:AEH60116.1, ECO:0000313|Proteomes:UP000006622};
RN [1] {ECO:0000313|EMBL:AEH60116.1, ECO:0000313|Proteomes:UP000006622}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 4017 / NBRC 107636 / OCM 62 / WeN5
RC {ECO:0000313|Proteomes:UP000006622};
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA Ovchinnikova G., Daligault H., Detter J.C., Han C., Tapia R., Larimer F.,
RA Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T.,
RA Wu D., Spring S., Schueler E., Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Methanosalsum zhilinae DSM 4017.";
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to
CC methylene-H(4)MPT. {ECO:0000256|HAMAP-Rule:MF_00058}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized
CC coenzyme F420-(gamma-L-Glu)(n) = 5,10-methenyl-5,6,7,8-
CC tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n);
CC Xref=Rhea:RHEA:16721, Rhea:RHEA-COMP:12939, Rhea:RHEA-COMP:14378,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57818, ChEBI:CHEBI:58337,
CC ChEBI:CHEBI:133980, ChEBI:CHEBI:139511; EC=1.5.98.1;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00058};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-
CC tetrahydromethanopterin (coenzyme F420 route): step 1/1.
CC {ECO:0000256|HAMAP-Rule:MF_00058}.
CC -!- SIMILARITY: Belongs to the MTD family. {ECO:0000256|ARBA:ARBA00007842,
CC ECO:0000256|HAMAP-Rule:MF_00058}.
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DR EMBL; CP002101; AEH60116.1; -; Genomic_DNA.
DR RefSeq; WP_013897555.1; NC_015676.1.
DR AlphaFoldDB; F7XNL9; -.
DR STRING; 679901.Mzhil_0239; -.
DR GeneID; 10821841; -.
DR KEGG; mzh:Mzhil_0239; -.
DR HOGENOM; CLU_1006890_0_0_2; -.
DR OrthoDB; 49844at2157; -.
DR UniPathway; UPA00640; UER00695.
DR Proteomes; UP000006622; Chromosome.
DR GO; GO:0008901; F:ferredoxin hydrogenase activity; IEA:InterPro.
DR GO; GO:0030268; F:methylenetetrahydromethanopterin dehydrogenase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.140.120; -; 1.
DR Gene3D; 3.40.50.10830; F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD); 1.
DR HAMAP; MF_00058; MTD; 1.
DR InterPro; IPR002844; MTD.
DR InterPro; IPR036080; MTD_sf.
DR Pfam; PF01993; MTD; 1.
DR PIRSF; PIRSF005627; MTD; 1.
DR SUPFAM; SSF102324; F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD); 1.
PE 3: Inferred from homology;
KW Methanogenesis {ECO:0000256|HAMAP-Rule:MF_00058};
KW One-carbon metabolism {ECO:0000256|HAMAP-Rule:MF_00058};
KW Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_00058,
KW ECO:0000313|EMBL:AEH60116.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006622}.
SQ SEQUENCE 278 AA; 30287 MW; 2D9F466F856E390D CRC64;
MAKIGFIKLG NLGISQVIEL VQDEIAAREG ISIRVFGTGP KMGKDEAAST EQFKDMSWDA
DFYVIISPNA SAPGPTAARE IWKDVPCIIV SDGPTKKDDR QALEEAGFGY IILKVDPLIG
AKTEFLDSVE MASFNSDAMK VLSTCGVVRL IQEELDKVVE QVDAGKSGSD IELPHILAKP
EVCVERAGFE NPYAKAKALA SLFMAEKVAQ INFPACFMMK ELEDVALTTA TGHEMMRAAA
ELAVQAREIE KINDTVSRHP HSKKGKVLSK TRLFEKPA
//
