ID F8AI49_PYRYC Unreviewed; 1274 AA.
AC F8AI49;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN OrderedLocusNames=PYCH_05880 {ECO:0000313|EMBL:AEH24276.1};
OS Pyrococcus yayanosii (strain CH1 / JCM 16557).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=529709 {ECO:0000313|EMBL:AEH24276.1, ECO:0000313|Proteomes:UP000008386};
RN [1] {ECO:0000313|EMBL:AEH24276.1, ECO:0000313|Proteomes:UP000008386}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH1 / JCM 16557 {ECO:0000313|Proteomes:UP000008386};
RX PubMed=21705594; DOI=10.1128/JB.05345-11;
RA Jun X., Lupeng L., Minjuan X., Oger P., Fengping W., Jebbar M., Xiang X.;
RT "Complete genome sequence of the obligate piezophilic hyperthermophilic
RT archaeon Pyrococcus yayanosii CH1.";
RL J. Bacteriol. 193:4297-4298(2011).
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010,
CC ECO:0000256|RuleBase:RU004070}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002779; AEH24276.1; -; Genomic_DNA.
DR RefSeq; WP_013905333.1; NC_015680.1.
DR AlphaFoldDB; F8AI49; -.
DR STRING; 529709.PYCH_05880; -.
DR GeneID; 10837164; -.
DR KEGG; pya:PYCH_05880; -.
DR eggNOG; arCOG00439; Archaea.
DR eggNOG; arCOG03145; Archaea.
DR eggNOG; arCOG03146; Archaea.
DR HOGENOM; CLU_000995_7_2_2; -.
DR OrthoDB; 6747at2157; -.
DR Proteomes; UP000008386; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR CDD; cd00081; Hint; 2.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 3.
DR Gene3D; 3.10.28.10; Homing endonucleases; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003586; Hint_dom_C.
DR InterPro; IPR003587; Hint_dom_N.
DR InterPro; IPR036844; Hint_dom_sf.
DR InterPro; IPR027434; Homing_endonucl.
DR InterPro; IPR006142; INTEIN.
DR InterPro; IPR030934; Intein_C.
DR InterPro; IPR004042; Intein_endonuc.
DR InterPro; IPR006141; Intein_N.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR01443; intein_Cterm; 2.
DR NCBIfam; TIGR01445; intein_Nterm; 2.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF43; DNA REPLICATION LICENSING FACTOR MCM6; 1.
DR Pfam; PF14890; Intein_splicing; 2.
DR Pfam; PF00493; MCM; 3.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR00379; INTEIN.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00305; HintC; 2.
DR SMART; SM00306; HintN; 2.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 2.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50818; INTEIN_C_TER; 2.
DR PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
DR PROSITE; PS50817; INTEIN_N_TER; 2.
DR PROSITE; PS50051; MCM_2; 3.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Protein splicing {ECO:0000256|ARBA:ARBA00023000}.
FT DOMAIN 278..334
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT DOMAIN 498..520
FT /note="Intein C-terminal splicing"
FT /evidence="ECO:0000259|PROSITE:PS50818"
FT DOMAIN 510..598
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT DOMAIN 732..803
FT /note="DOD-type homing endonuclease"
FT /evidence="ECO:0000259|PROSITE:PS50819"
FT DOMAIN 982..1004
FT /note="Intein C-terminal splicing"
FT /evidence="ECO:0000259|PROSITE:PS50818"
FT DOMAIN 997..1075
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT COILED 940..967
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1274 AA; 145950 MW; 60B8B6D5446F0363 CRC64;
MDRDEMINRF VSFLREYADE SGEPVYKERI NDILTVTPKR SISIDWTHLN SFDPELAEEL
LNNPEESIAA AEDAIQIVLK EDFFKEEPPK VHARFFNLPE TLLVKEIGAE HINRFIQVEG
IITRVSEIKP FVRTAVFVCR DCYNEMIRVQ RPYGGMTKVT RCEQCGSKNI ELDVNKSSFI
NFQTFRLQDR PESLKGGQMP RFIDAVLLDD LVDTALPGDR VLVTGILRVV QEKGDKTPIF
RKIIEVNHIE PLSKEMEELE ITPEEEQKIR ELAKRKDIVD AIVDSIAPAI YGYREVKKGI
ALALFGGVPR TLPDGTRLRG DIHVLLVGDP GVAKCVDYHT KVLLADGSLK EIGEIVEKAI
EKAKVEGTLE TVDDGFYAPI DLELYALDAK TLKVRKVKAN IAWKRTAPKK MFRIKTANGR
EIRVTPTHPF FTFEDGHFRT KKAEELRVGD FIAVPRRENE PRIVPETEDE SLRKLLEESD
IFWDRVVEIE EYKPEHGWVY DLQVPEHHNF IANDIFVHNS QLLRYVANLA PRAIYTSGKS
SSAAGLTAAA VRDEFTGGWV LEAGALVLAD GGFAMIDEID KMSDRDRSVI HEALEQQSYH
RNFELLLADG RKVKIGEFVD EIIERNRDRV IIGKDTEILP VEDVYILAYD PKRGQIVRVR
ADRVSRHKPP EKFIQIKLEN GREILVTPEH PVLVWENGVK EVPAEDLRPG DFAIGVREYP
PLGEEEGDIE AVLRNLFKEG SNRFKKGARI PPEVFRFRRE LLEELVRRIW TIRGRGLNGK
PVIRFPSREL AEDFQDLLLF LGVCSTLREG VGSFSLIVQE RECIKRLEEI TGKRFGEGRE
EKVPGDFGRA ILEAADLLGL RIPAGSRSRL RRKVVSRNIV LKYSQQVQET IERLKRAIEN
DDMERVVEIL PKWRLYYEHG ISPFSLRRRL SDEKIRKIVK EEATKRLEKA EKLIEFVERN
LERIRFVRIV AVNEVPNKDS EWVYDVTVEP HHLFVSHGLV LHNTISISKA GITATLNARA
TVIAAANPKH GRFNRMKPIS EQLDLPPTLL SRFDLIFVLI DEPDEEIDSA IATHILRVRR
GESEVVTPKI PHDLLRKYIA YARKNVHPVI SEEAIEEIRK YYVKMRRSAK RLTEKDEEGI
RPIPITPRQL EALIRLSEAH AKMRLSPIVT REDAREAIKL IEFTLGQIAR DEEGQIDVTI
LEVGQSAKKL SKVEKILAII EKLEKVNEKG AYIEDILEEA SRAGIERKEA RDIIEKLLRG
GQIYMPETGY YKTL
//