ID F8DGH7_STREP Unreviewed; 799 AA.
AC F8DGH7;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=CRISPR-associated endonuclease Cas3-HD {ECO:0000313|EMBL:AEH55426.1};
DE EC=3.1.-.- {ECO:0000313|EMBL:AEH55426.1};
GN OrderedLocusNames=HMPREF0833_10395 {ECO:0000313|EMBL:AEH55426.1};
OS Streptococcus parasanguinis (strain ATCC 15912 / DSM 6778 / CIP 104372 /
OS LMG 14537).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=760570 {ECO:0000313|EMBL:AEH55426.1, ECO:0000313|Proteomes:UP000001502};
RN [1] {ECO:0000313|Proteomes:UP000001502}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15912 / DSM 6778 / CIP 104372 / LMG 14537
RC {ECO:0000313|Proteomes:UP000001502};
RA Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A.,
RA Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X.,
RA Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J., Deng J.,
RA Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A.,
RA Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B.,
RA Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M.,
RA Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N.,
RA Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W.,
RA Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J.,
RA Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L.,
RA Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M.,
RA Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G.,
RA Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M.,
RA Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L.,
RA Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.;
RT "Complete sequence of Streptococcus parasanguinis strain ATCC 15912.";
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
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DR EMBL; CP002843; AEH55426.1; -; Genomic_DNA.
DR RefSeq; WP_013903477.1; NC_015678.1.
DR AlphaFoldDB; F8DGH7; -.
DR GeneID; 75175304; -.
DR KEGG; scp:HMPREF0833_10395; -.
DR HOGENOM; CLU_010123_0_0_9; -.
DR Proteomes; UP000001502; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd09641; Cas3''_I; 1.
DR CDD; cd17930; DEXHc_cas3; 1.
DR Gene3D; 1.10.3210.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR006474; Helicase_Cas3_CRISPR-ass_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01587; cas3_core; 1.
DR NCBIfam; TIGR01596; cas3_HD; 1.
DR PANTHER; PTHR47957; ATP-DEPENDENT HELICASE HRQ1; 1.
DR PANTHER; PTHR47957:SF3; ATP-DEPENDENT HELICASE HRQ1; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF01966; HD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51643; HD_CAS3; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Endonuclease {ECO:0000313|EMBL:AEH55426.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AEH55426.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 8..215
FT /note="HD Cas3-type"
FT /evidence="ECO:0000259|PROSITE:PS51643"
SQ SEQUENCE 799 AA; 92131 MW; 9390244AC04C0B45 CRC64;
MILAHKDNNG NVQSLQDHSF NVATKAREDA NAIDQGDILF LLGLYHDLGK ANQEFQDKLL
LHPNKHVDHS SAGARYLFQK IQVCLKSLNV EKTDREFFQE ICAYVISSHH GMYDILLQDE
TINASQYAYN RLRYRIIEGT ESNRYQEDIE PFAQKLESQL PYYGYCSLDD LIKKSFENYQ
QAWSNLKWSD ESEKDFYSSC FIRLYLSLLK NADILDTINA YGIIVQPLKS EEREELNQSY
LNAIEEKYRG FDNPTTRLNE VRLQISERVK ERGENDSAGI YRLDLPTGAG KTNLSMRYAF
HQLVKQKKSR YFYITPFLSV LEQNASEIKK ITGDAGVLEH HSNVIHKDDD NDDKKTLMLD
YLIDSWDSQI ILTSMVQFFQ TLFKTKSSNI RRFSNLANSV LILDEVQSLP IEVTTLFNLT
MNFLNKVMNT SIILCTATQP AYDSPVITNR LDYGGKNGEC PDIVELTHDE TEVFARTELR
KYNEENQHTN LAELVDFVLD NNESILAIFN TKKTVDKFYT MLEELTDRPL YQLSTNMCAQ
HRFDMISEIK QHLQDGVPII CISTQLIEAG VDVDFNQVIR SYAGIDSIVQ ASGRCNREGK
RQKGQVTLVN LKNEEENISR LKEIKNKKEA TEFILHENSS PIDTSLLNKD FFEYYYANNQ
ASMDYPLSHG ESVFDYLSIN EYQLRPNFKG RMKQAFKTAG QKMNLINNET IGVLVPYGDA
IEKLSRLEEI CESDYPSEGE FQIIKSLLKE LQSYTVNVRE HDPILEATKS YLNGNVLVLS
DGYYHEKKGI TIEMLNFIM
//
