ID F8GAE0_FRAST Unreviewed; 485 AA.
AC F8GAE0;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Glycogen synthase {ECO:0000256|ARBA:ARBA00019935, ECO:0000256|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000256|ARBA:ARBA00012588, ECO:0000256|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000256|ARBA:ARBA00031722, ECO:0000256|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000256|HAMAP-Rule:MF_00484};
GN OrderedLocusNames=F7308_1819 {ECO:0000313|EMBL:AEI36743.1};
OS Francisella salina.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Francisellaceae; Francisella.
OX NCBI_TaxID=573569 {ECO:0000313|EMBL:AEI36743.1, ECO:0000313|Proteomes:UP000000490};
RN [1] {ECO:0000313|Proteomes:UP000000490}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TX07-7308 {ECO:0000313|Proteomes:UP000000490};
RA Kuske C.R., Challacombe J.F., Siddaramappa S., Petersen J.M.;
RT "The complete genome of Francisella sp. TX077308.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000256|ARBA:ARBA00002764, ECO:0000256|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000256|ARBA:ARBA00001478, ECO:0000256|HAMAP-
CC Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004964, ECO:0000256|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily.
CC {ECO:0000256|ARBA:ARBA00010281, ECO:0000256|HAMAP-Rule:MF_00484}.
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DR EMBL; CP002872; AEI36743.1; -; Genomic_DNA.
DR RefSeq; WP_013923571.1; NC_015696.1.
DR AlphaFoldDB; F8GAE0; -.
DR STRING; 573569.F7308_1819; -.
DR KEGG; frt:F7308_1819; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_2_6; -.
DR OrthoDB; 9808590at2; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000000490; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd03791; GT5_Glycogen_synthase_DULL1-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR NCBIfam; TIGR02095; glgA; 1.
DR PANTHER; PTHR45825; GRANULE-BOUND STARCH SYNTHASE 1, CHLOROPLASTIC/AMYLOPLASTIC; 1.
DR PANTHER; PTHR45825:SF11; STARCH SYNTHASE 1, CHLOROPLASTIC_AMYLOPLASTIC; 1.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis {ECO:0000256|ARBA:ARBA00023056, ECO:0000256|HAMAP-
KW Rule:MF_00484};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676, ECO:0000256|HAMAP-
KW Rule:MF_00484};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00484}.
FT DOMAIN 2..242
FT /note="Starch synthase catalytic"
FT /evidence="ECO:0000259|Pfam:PF08323"
FT DOMAIN 294..458
FT /note="Glycosyl transferase family 1"
FT /evidence="ECO:0000259|Pfam:PF00534"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00484"
SQ SEQUENCE 485 AA; 52833 MW; 3546F0C8C4B0B1E3 CRC64;
MRVLHVCSEL YPILKTGGLA DVTAALPPAL ASFGVDSRVL VPGFPAFMNA IKDKQLLMNI
PSRFGAEEIN IFLAKIPNTK IDIYVIDAPS LFARPGNPYA DSSNQAYADN YLRFALLGWV
AARISEGLDT KWKPEVVHSH DWHAGLVPAY IKASELASGK KAVKTVFTVH NLAYQGLFPM
SVFAELDLPG IFLSMNGLEF YGQVSFMKAG LYFADKITTV SPTYAKEIQS YEQGCGLEGL
LADRHNDLYG VLNGVDPQVW NPKKDTLIEA NYSITTANVG KAKCKAALQK MTGLAKKEDA
VVFGIVTRLT EQKGLNLLIE AIGEITSRGG QVVLLGSGDK ALEEAFLAAA KKSPKSIAVQ
IGYDENQAHR IIAGSDVIMV PSRFEPCGLT QLYGLTYGTL PLVHKVGGLA DTVTDSSLEN
LADGMATGFV FDEFSVESLT LAIRRAFALY NRKADWKKVR KTAMQQKVDW NAAADKIHQI
YSQLV
//
