ID F8II28_ALIAT Unreviewed; 705 AA.
AC F8II28;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Peptidoglycan glycosyltransferase {ECO:0000313|EMBL:AEJ44508.1};
GN Name=mrdA {ECO:0000313|EMBL:AEJ44508.1};
GN OrderedLocusNames=TC41_2613 {ECO:0000313|EMBL:AEJ44508.1};
OS Alicyclobacillus acidocaldarius (strain Tc-4-1) (Bacillus acidocaldarius).
OC Bacteria; Bacillota; Bacilli; Bacillales; Alicyclobacillaceae;
OC Alicyclobacillus.
OX NCBI_TaxID=1048834 {ECO:0000313|EMBL:AEJ44508.1, ECO:0000313|Proteomes:UP000000292};
RN [1] {ECO:0000313|EMBL:AEJ44508.1, ECO:0000313|Proteomes:UP000000292}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tc-4-1 {ECO:0000313|EMBL:AEJ44508.1,
RC ECO:0000313|Proteomes:UP000000292};
RX PubMed=21914900; DOI=10.1128/JB.05709-11;
RA Chen Y., He Y., Zhang B., Yang J., Li W., Dong Z., Hu S.;
RT "Complete Genome Sequence of Alicyclobacillus acidocaldarius Strain Tc-
RT 4-1.";
RL J. Bacteriol. 193:5602-5603(2011).
RN [2] {ECO:0000313|Proteomes:UP000000292}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tc-4-1 {ECO:0000313|Proteomes:UP000000292};
RA Chen Y., He Y., Dong Z., Hu S.;
RT "The complete genome sequence of Alicyclobacillus acidocaldarius sp. Tc-4-
RT 1.";
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; CP002902; AEJ44508.1; -; Genomic_DNA.
DR RefSeq; WP_014465340.1; NC_017167.1.
DR AlphaFoldDB; F8II28; -.
DR STRING; 1048834.TC41_2613; -.
DR KEGG; aad:TC41_2613; -.
DR PATRIC; fig|1048834.4.peg.2471; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_1_2_9; -.
DR OrthoDB; 2378949at2; -.
DR Proteomes; UP000000292; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000313|EMBL:AEJ44508.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 33..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 75..242
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 289..666
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 705 AA; 77560 MW; 23A8FF8412002F0E CRC64;
MRRSRTKRAQ RRDGAVTPPD PAKIAKRRRF RVHVVYSLVF LSFTSLILRL AYVQVVKGAS
FRASEQLTQY ARVPILPQRG WVYDANGQVL AWDKPVLTIQ FNRYTQISDA EMHRVASILA
PVLQTTPQAL YQAMQSDPGA LQVTLARNVT DAQVAYVVEH QSELPNIQVV QDYERQYPYG
DLAGQVLGYV GAITAQNVSQ YKGYLYSQQV GETGIEYEYE HLLQGKPGYE LVTVTSSGTA
VGSVGEIAPQ NGDNIQLTLD GHEQAVAQEL LQNMIDSSQT NKQDITDAAA VMLNVKTGGV
IAMVSYPYLD PNWYTDGTYV NHVHYLETSG AQLNNVIDTF NYPGSTVKPA NMLAALKAGV
VTPKTEILDD GYIYIGTQRK NEDEGFVFGW VNPIEAITVS SDVFFYELGL HLGKWFGSSP
TSGGTYPASD GSYQNYLDTD FVKGINAMFQ EEEDFGLGTL TGIDLPFEEH GEFYIEDYRK
GNIQVPYNLQ ASEASIAKTG KYVNYGSPAS LADAAIGQSQ MFTPMELGVY AMTLADEGLR
LKPHLLENVY APNGTPNSGA KPIFTYKTQI LGRVSAAPWQ WDLIKQGMYG VTSNPAGTAY
YAFLGAPYQA AGKTGTAQIV INGHRTDNSV FICYAPLNHP LVAVAVMAPG GGYGASFSAI
LARKMIDAYF DEHHEPWMPK SQWTNTAIPS NWTQSPAYLL PEQSH
//
