ID F8JDP1_HYPSM Unreviewed; 536 AA.
AC F8JDP1;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Putative methyltransferase {ECO:0000313|EMBL:CCB66503.1};
DE EC=2.1.1.- {ECO:0000313|EMBL:CCB66503.1};
GN OrderedLocusNames=HYPMC_3288 {ECO:0000313|EMBL:CCB66503.1};
OS Hyphomicrobium sp. (strain MC1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Hyphomicrobiaceae; Hyphomicrobium.
OX NCBI_TaxID=717785 {ECO:0000313|EMBL:CCB66503.1, ECO:0000313|Proteomes:UP000000494};
RN [1] {ECO:0000313|Proteomes:UP000000494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC1 {ECO:0000313|Proteomes:UP000000494};
RA Genoscope.;
RT "The complete genome of Hyphomicrobium sp. MC1.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; FQ859181; CCB66503.1; -; Genomic_DNA.
DR RefSeq; WP_013948900.1; NC_015717.1.
DR AlphaFoldDB; F8JDP1; -.
DR STRING; 717785.HYPMC_3288; -.
DR KEGG; hmc:HYPMC_3288; -.
DR eggNOG; COG1032; Bacteria.
DR HOGENOM; CLU_021572_5_0_5; -.
DR Proteomes; UP000000494; Chromosome.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR025274; DUF4070.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034530; HpnP-like.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF3; HYPOTHETICAL METHYLTRANSFERASE; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF13282; DUF4070; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00303; hopanoid_C2-methyltransferase; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Methyltransferase {ECO:0000313|EMBL:CCB66503.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000494};
KW Transferase {ECO:0000313|EMBL:CCB66503.1}.
FT DOMAIN 1..140
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 161..395
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 536 AA; 60398 MW; 20D5A00E507EBA5B CRC64;
MADIIIINPR FDVSFWGMEK CMGMLGKRAN LPVACLPLLA ALVPKHHDVT LIDENVDEID
FERVGRADIV CATGMSIQGR RLREILAEVR RRGVLTVVGG AMATVEPQEL EGLADVIFVG
EADETFPRFL REWELGNHAS RYVQADKTDM TTLPPPRLDL LKSQHYMFGS MQISRGCPFT
CEFCDIIVTF GRKPRLKSSA QVIAELDAYY RAGIKIVFVV DDNLIGNKKA IKPILRDMIL
WQEKHAYALT LFTEASLDLA EDDELMELMG RAGFQSVFIG IESPNEASLR ETKKLQNVRE
RAGTLIERVH RIQNRGLDVW CGMIVGFDSD KASVFGELPR FLNEARIGNA LIGLLHAIPT
TPLYDRLRNE GRLNDDEDSA AFGTNVAPLG MSREDLRKGF VMVTGQAYSA DAYFNRIDAL
FVDGNFRFAA HRLAYWRSHR LAWTKSCIEN YLMFFVLAGR LVSGNVDPKL RTKYRSQLLR
AFWARRFEPQ LLFTYAVKTA MHYHYASISD ELTAAGDGPL PQAVRSFSRS PGREAA
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