ID F8K322_STREN Unreviewed; 4349 AA.
AC F8K322; G8X1I7;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Type I modular polyketide synthase {ECO:0000313|EMBL:AEW92516.1};
GN OrderedLocusNames=SCATT_01450 {ECO:0000313|EMBL:AEW92516.1};
OS Streptantibioticus cattleyicolor (strain ATCC 35852 / DSM 46488 / JCM 4925
OS / NBRC 14057 / NRRL 8057) (Streptomyces cattleya).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptantibioticus.
OX NCBI_TaxID=1003195 {ECO:0000313|EMBL:AEW92516.1, ECO:0000313|Proteomes:UP000007842};
RN [1] {ECO:0000313|Proteomes:UP000007842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057
RC {ECO:0000313|Proteomes:UP000007842};
RA Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.;
RT "Complete genome sequence of Streptomyces cattleya strain DSM 46488.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP003219; AEW92516.1; -; Genomic_DNA.
DR RefSeq; WP_014140914.1; NC_017586.1.
DR STRING; 1003195.SCATT_01450; -.
DR KEGG; scy:SCATT_01450; -.
DR PATRIC; fig|1003195.11.peg.1792; -.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_35_8_11; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000007842; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd08952; KR_1_SDR_x; 1.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 3.30.70.3290; -; 3.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 6.10.140.1830; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 3.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF18369; PKS_DE; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 3.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 3.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 3.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007842};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 14..429
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 903..980
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 998..1420
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2648..2723
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2741..3165
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4183..4258
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 430..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1989..2025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2618..2644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2717..2741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4349 AA; 453189 MW; 34ACD1F181747144 CRC64;
MWKGTIRVDV RAQGDNIAVV GASCRFPGAD GPRQLWRLLA EGRHAITERP PGRRGSSRTV
APPWGGFLDA VDEFDAEFFG ISAREAASVD PQQRLVLELG WEALEDAGIV PDSVRGGRLG
VFVGAFADDY AHLVHRNGSA AATQHTYPGI ERAVIANRLS HFLDVRGPSV GIDSGQSSSL
VAVHLACQSL LTGESDLAVA GGVQLNLLPE SVDIADRWGP LSPDGRCYTF DARANGYVPG
EGGGLVVLKR LEDALADGDT PQCVILGSAV NHGGNGHALT QPDELAQRDV LRRAHERARI
SAEQLQYVEL HGTGTPAGDP VEASALGAVV GSARPRTRPL PVGSVKTNLG HLGAAAGIAG
LIKVVMSIRH RQLPASLNFE LANPEIALDE LNLRVQQGLG SWEAPDSPLI AGVSSFGMGG
TNCHLVISDV PPGSTAPRGN PETGEADSGR SPAVLPFVLS GRGVGALCGQ AARLRSFVVE
RPGVALADVA YSLTADRAVH GHRAVVVASG REQLLDRLAV VAGGGSGVGC GSGVAGGGRV
AVVFTGQGSQ RVGMGRELYG RFPVFAAAFD QVCGLLDPVV RAAVFGEGGA GGLLDSTEVA
QPALFAVEVA LFRLFGSWGV VPDFVTGHSV GEVAAAHVSG VLSLADACAL VTARGRLMQG
LASGGVMVAV AAGEDVVAPV VAELGGRVSI AAVNSPVSVV VSGAESAVER VVRRLSGRGC
RTKRLVVSHA FHSPLMEPML EDFRAVVAGL AFQPPCIGTV NEAVADPEYW VRHVRDTVRF
ADTVMGLRER GVTRFVELGP DAVLTGAVRE CLDGQEITAV PGLRHGHGEV ESVLAGLGAL
FTAGVAVNWP EVFTGTGARH TELPTYAFQR QHYWLGMPLD DEKTSVETPA LVSELRRLGE
TERTYRMTEL ARAHITATLG GGVLGEGALG QTFRDLGFDS LMSAELRDRL SRALEITLPS
SVIFDYPTPA VLIDHLQSVV LGADAVVDTQ AASIADPDDP VVIVGMACRY PGGVGSPEDL
WSLVVEGREG ITGFPESRGW DVEGLYHADP DHPGTTYARG GGFLHDAGEF DAGFFGISPR
EATAMDPQQR LLLEVAWEAF ERAGIDADSL RGTRTGVVVG ATPHGYGAVG TDAAGYLLTG
TTPGVLSGRI AYQFGLEGPA TTVDTACSSS LVALHLAAQA LRSGECSLAL AGGVAVMGTP
MILTEFARQR GLSPDGRCRS FGAGADGTGW SEGVGLVVLE RLSDARRNGH RVLALLAGSA
VNQDGASNGL TAPNGPSQQR LIRQALANAG LTAADVDVVE GHGTGTRLGD PIEAQALLAT
YGREHTDGSP LWLGSVKANI GHPQAAAGVA GVIKMVMALR HRFLPSTLFA EDPSTEVDWS
SGGVALLTRS REWPDTGRPR RAGVSSFGIS GTNAHVILEQ APNEPATADR RPTRTATREL
PVLPFVLSGR GVGALCGQAA RLRSFVVERP GVALADVAYS LTADRAVHGH RAVVVASGRE
QLLDRLAVVA GGGSGVGCGS GVAGGGRVAV VFTGQGSQRV GMGRELYGRF PVFAAAFDQV
CGLLDPVVRA AVFGEGGAGG LLDSTEVAQP ALFAVEVALF RLFGSWGVVP DFVTGHSVGE
VAAAHVSGVL SLADACALVT ARGRLMQGLA SGGVMVAVAA GEDVVAPVVA ELGGRVSIAA
VNSPVSVVVS GAESAVERVV RRLSGRGCRT KRLVVSHAFH SPLMEPMLED FRAVVAGLAF
QPPCIGTVNE AVADPEYWVR HVRDTVRFAD TVMGLRERGV TRFVELGPDA VLTGAVRECL
DGQEITAVPG LRHGHGEVES VLAGLGALFT AGVAVNWPEV FTGTGARHTE LPTYAFQRQH
YWLEPPSRPD TDLAAVGLEP VDHPFLRAEM PLGDAGALVL TGRLSVNRQP WLADHVVLGT
PILPGTGFLA LALHAARRTG AGPVEELVVR APLVVPEHGD TQLQVVIDAP DGTGRRALRV
LSRTADTAGN GTWTRHAEGT VAPPAGLPSV GPASGTGPNG EAGPDAQPIA IAAAYAGLTR
RGYDYGPAFR GLRAVRRGDG EVFADIVLDE AAGDSGPGFD LHPALLDAAI QAALVGLFET
ADETLVPFAW SGVTVHTAAP PALRARISRT GADSVAMMLT DLEGNPVASI DSLVLRPAPD
APRTPPADRS EAALFRLSWL PKEVGAHPGT GHWAMVGEDP HDLGAELTGD GSPLDRYSDL
SALRAAMAAG APTPSTVITV VPPTDVTDVG GPHRVLRLVQ DWLADGTMAD APLVVVTTGA
VATGGNGRLD LDNAPVWGLL RTAQSEHPGR IVLVDVAPGS EGARRLAAAV ATGEPQLALS
AEGVRVPRLT RLPVDPGPHP AAEKPIPERG TVLLTGAFGR LGRLLARHLA TEHEVTSMLL
VSRSGPATPE ARALVAELTA LGVDVRAEAC DVADRAELAA VLRGLPADRP LTAVVHTAGV
LDDGVLTELS PQRLDAVMGP KAVAAKNLHE LTADMPLSAF VLYSSISGLI GAAGQANYAA
ANTYLDALAH HRARLGLPAM SLAWGLWDQR GGMAAALSAG DLNRMARSGI ATLSETEGLT
LFDAALRRSE PLLVPLRLDT ASATDGGNAH PLLRELTTSA PRPARPAAVP GRPDGPRRVG
EEVTSRPGRL LELVRAEAGR VLGYDGRDSI GADRTFKEFG LDSLTAIELR NRLNAVTGSR
LGTTAVFDYP TPRALADHLS GELTPSGGTA DTTSSPAGDP DDPVVIVGMA CRYPGGVGSP
EDLWSLVVEG REGITGFPES RGWDVEGLYH ADPDHPGTTY ARGGGFLHDA GEFDAGFFGI
SPREATAMDP QQRLLLEVAW EAFERAGIDA DSLRGSRTGV FAGVMYHDYA PAVDLVPDQL
SGAVLTGSAG SVLSGRVAYQ FGLEGPAVSV DTACSSSLVA LHLAAQALRS GECSLALAGG
VTVMSTPMTF VDLGHQRALS PDGRCRAFGA GADGTGWAEG VGLVVLERLS DARRQGHQVL
AVLKGSAVNS DGASNGLTAP NGLSQQRVIR QALASAGLTP SNVDVVEGHG TGTKLGDPIE
AQALLATYGQ DRETPLWLGS LKSNIGHTQA AAGVGGVIKM VMAMRHGVLP RTLHAERPSP
FVDWSQGAVA LLDRNHDWPR TGRPRRAGVS SFGISGTNAH VILEQAPEQP AAGHSDAVTR
LGVSAFPVSG RGWAALAGQA TRLRAALADS PDTDVAGFGA ALTSRGAPHP HRAVVIAENR
HELLAGLDAI AAGQSENSAL VVAGAGETDH DGPVFVFPGQ GGQWLGMGIE LWKSSPTFAE
LMRTCDEALA PWVDWDGFSL WDVLAGVPGA PSLDRDDVVQ PALFAVGVSL SRLWASLGVR
PSAVVGHSQG EFAAAVAAEA LSLTEGARVV SLRSRVLRRL ATQGGMGWLN RSADEVRERL
AGCPALGVAA VNGPMSTVVS GATAELDQLL SVWESEGARV RRVPINYGSH SAEVEVVRAE
LADTLGVVEC SPGTVPFYST VTGSLLDGRK LDADYWYRNL REMVRFAEVV DQLLSDGHRS
FHEVGAHPVL VHAIQELAEA RGTSVTTVGT LRRGHGDARE FLRNAAEAFV GGVDVRWSEL
FPSGQQPVRL PTYAFQHTHY WIETPPSRSS RGTEVDTGFW KMVDQGDLDG LTTALAISDD
AGRSSLGTVL PALSSWRERS RQQATLAGWQ YRVTWRPTEG SDRPLTGRWL VVVPAECAEP
AWLGQVIAAL SARGVQVGRL DVPRAADAEA LRHELVRALD GEPAGSILSL LAMDTAEDTD
AVSVPVGLSG TLALVRAVSG LGLSTPIWCV TQDAVVVRPG DAVTQPRQAA LWGFARHAGL
EQPVSWGGVV DLPREVGPAD LAALAGALGD GESELAVRGG AVFRRRLTRV TAPAPRTRQP
LVERSALITG GTGALGAEAA RWLVRRGARH LVLASRRGPA APGAAELAAE LTGQGASVSV
VACDVADRAQ LADLLADWPA EHPLTTVVHT AGVLDDGVID RLTPERFERV FRPKVAAAWH
LHELTKDRDL VDFVLFSSFV GTVGPAGQAN YAAANSSLDA LAAHRRALGL TGTSIAWGLW
QGPGIADREG VEHQLAARGL RAMDPRRAVQ AMDQVIDRDE TAVVVVDVEW SSFATELAGT
RSMSLLAELL EAGKDDPEGP ADGAADTGVR ERLVGLPATE RTYAITDLVR ATVAAVLGHP
DVSSVESGRS FQESGFDSLT ALRFRNRLGV ATGLQLPATL IFDYPTPASV AELVHAELFG
EDAGAHGSET GEGVDDAGLK KIIDRIPIAT LRQAGLVDAL LRLVGTVPEG EPADSAGPTT
AIDSMDMADL IRAAYGRADA SDRAEGPTS
//