ID F8Q023_SERL3 Unreviewed; 4889 AA.
AC F8Q023;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=SERLA73DRAFT_110025 {ECO:0000313|EMBL:EGN98495.1};
OS Serpula lacrymans var. lacrymans (strain S7.3) (Dry rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Boletales; Coniophorineae; Serpulaceae; Serpula.
OX NCBI_TaxID=936435 {ECO:0000313|Proteomes:UP000008063};
RN [1] {ECO:0000313|Proteomes:UP000008063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain S7.3 {ECO:0000313|Proteomes:UP000008063};
RX PubMed=21764756; DOI=10.1126/science.1205411;
RA Eastwood D.C., Floudas D., Binder M., Majcherczyk A., Schneider P.,
RA Aerts A., Asiegbu F.O., Baker S.E., Barry K., Bendiksby M., Blumentritt M.,
RA Coutinho P.M., Cullen D., de Vries R.P., Gathman A., Goodell B.,
RA Henrissat B., Ihrmark K., Kauserud H., Kohler A., LaButti K., Lapidus A.,
RA Lavin J.L., Lee Y.-H., Lindquist E., Lilly W., Lucas S., Morin E.,
RA Murat C., Oguiza J.A., Park J., Pisabarro A.G., Riley R., Rosling A.,
RA Salamov A., Schmidt O., Schmutz J., Skrede I., Stenlid J., Wiebenga A.,
RA Xie X., Kuees U., Hibbett D.S., Hoffmeister D., Hoegberg N., Martin F.,
RA Grigoriev I.V., Watkinson S.C.;
RT "The plant cell wall-decomposing machinery underlies the functional
RT diversity of forest fungi.";
RL Science 333:762-765(2011).
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR EMBL; GL945481; EGN98495.1; -; Genomic_DNA.
DR STRING; 936435.F8Q023; -.
DR HOGENOM; CLU_000050_0_2_1; -.
DR InParanoid; F8Q023; -.
DR OMA; ILEQWHR; -.
DR OrthoDB; 1221059at2759; -.
DR Proteomes; UP000008063; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 8.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 2.
DR SMART; SM00382; AAA; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000008063}.
FT DOMAIN 4661..4857
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 4027..4450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4500..4519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4054..4092
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4093..4125
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4146..4162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4163..4216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4232..4249
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4250..4265
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4266..4280
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4287..4301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4331..4349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4366..4409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4422..4450
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4500..4517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4889 AA; 546587 MW; E88D7B2A1A7178BF CRC64;
MAFTNTVHDP LTINLAKQTR ALLCCIPAES IYAQNVIQAS SPKDLLSTLS RLLAVPALTL
LVAKTFRPLL LDLCVRWLHD DDDLENRFAA LCLLIEPHEE IFPVFSVFLR KPFFENGPLD
FVMASLAPGT LDSARLHRVL LAYYRLLQAN RLLPHHRIWS LSPLSALIWT PHPDTGVRWL
AIRCYSLQSG MGEAEREKIE TCVLGEICGV DCPITYEQNT DGIVKELDGW LLPTLETKRI
IDARNALIED DQNFYTYEDG DICQPLLDSD LSRSTANIHG VFLLRSSVPS EVSPTVVATP
SAIESLRVIA LHISSCLPIL LTSAPSSGKS LFLSYLASAL YPSTKNKIVT VHLADTSLDP
RSLLGSYVSS PTQLGTFEWK DGILVRAMKE GRWVVFEDID RGSSEVLGLI KPLVESLGLG
NWIGCRAAME VPHRGRVEAE EGFAIFATRS VMSSRNDSFP SPSFFGAHKF HEINVSSPTA
TEVKAIIDAQ FPKLAGSTAQ ALIELWGSVR SLGSTASVRS VGLRELEKFC HRIETLLPPN
HQPMDIEFTP GGPAILTSVF PNPTIREDIY LEARDVFFGA GTLTASARAH CDRMADVVAE
HLGLDSDRRR WVLTGRTPDF EVEKDVNGQS VSVRVGRTRL LARSTRASIM PALERPFAMH
KPAVCLLSRI ATAVSLAEPV LLTGETGTGK TSVVTHLASL LRRPLISLNL SHQTESSDLL
GGFKPIDARI PGAILQERFL ELFGRTFSWK KNAKFSDTVR KAVADAKWKR VVGLWKESVR
LARDRIHARQ NENAADDVHK NVDADAPRKR RKVEATSLQE SEVAWSAFQE DVEEFEVQHT
QGKGKFAFDF VEGPLVRALR SGDWILLDEI NLASPETLEC ITGLLRGPTA SITLTEQGSL
EPVPRHPDFR LFACMNPATD VGKKDLPPNI RSRFTEIDVP PPDADRETLL SIVAQYIGPS
AVGDKAAIMN VAEFYSAVKK LAEDRQIADG SNHRPHYSMR TLARALTFAA DIASAYSLRR
ALWEGCLMAF TMVLDQPSSE IVTNLAQKHV LAGVRNPRSL LSKEPSVPKT RPPEDFVKFG
PFYLEKGGLT IDPFDDYIIT PSVEKKLVDL ARIIITRRFP VLIEGPTSSG KTSSIEYLAR
RTGHRFIRIN NHDHTDIQEY LGSYVSDPNT GKLVFKDGLL VRALRNGDWI VLDELNLAPT
DVLEALNRLL DDNRELIIPE TQEVIRPHPH FMLFATQNPP GVYAGRKVLS RAFRNRFLEV
HFEDVPQVEL ETILCQRCRI APSYSQRIVS VFRELQKRRQ SGRVFESKQG FATLRDLFRW
AGRDAIGYQE LAENGYMLLA ERARRDDDKV VVKEVIESVM KVRIDEKEMY NFRDGMDHFV
DCPIPSKSQI VWTAAMRRLF VLVARALRFN EPVLLVGETG SGKTSVCQIF AEITSKQLYA
VNCHQNTETA DLIGGLRPIR NRSGAQAEIL REVSVILERL GLTNMETDVR GLIERIAGLL
NTDLDATVIS SLKDLHHRLL QTTSIFEWND GPLVDAMRNG DVFLLDEISL ADDSVLERLN
SVLEPGRTIV LAERGGDNID YSSIHAAEGF KLMATMNPGG DYGKKELSPA LRNRFTEIWV
PPVDNRSDLH LIVESSWGYD IFKPYTNHLL DFTEWLQEKI DRSVCSLRDI LAWVNFSNAV
YSTEITGHIQ MDAIFHHAAH MTFIDGFGSL PQLSGYSSDA LRELEAETIC KLQELVPSSD
HDGSLTFARD SSKLVQLGSF AISKGPEEPS VHNFSLQAPT TRENASRVLR ACQVPKPILL
EGSPGVGKTA LITALANITG HHLCRINLSD QTDLIDLFGS DLPVEDGQPG EFAWKDAEFL
RAVQEGYWVL LDEMNLAPQA VLEGLNAILD HRGSVYIPEL GRSFNRHPAF RVFAAQNPLH
QGGGRKGLPK SFVNRFTKVY MEDLSADDLL LISQQLFPER NADILRAMIT YNTRLNQEVV
IKRSFGRDGS PWEFNLRDVI RWGELLRSYG FSGQPIDCLR NIYLNRFRLP ADRESARLLF
EDIFSVSTSH LTYAPYPFLS PSHFRIGRFE MARKNTTLLA RPRCVLQSHL SALESIGTCI
SQSWLVILTG RHSTGKTELL RVMANLTGNH LHELSINSAT DTMDILGSFE QVDHHARVYR
LAEQVLLLVE QTARYSSGSA VSYTSYYELR KTIQFSSSNF VPVHRILQSV ASVLHDFDLC
VSGDRAGPWT SKKAELELQM QCLTAMPNAI GRFEWVDGPL VQAMKEGFWL VLDGANLCNP
SVLDRLNSLC ELDGVLALSE RGYVDGKVPM LRPHPNFRLF MTVDPHHGEL SRAMRNRGIE
TAVLGDFTEE DERRLCDYLR FPQTQRMNSP IAFAMYESVR RGIYSQTPFQ VVGNGWPSGS
SVDQDVASSF LGSHASFFAS LPSPPPSSVE KEALPHFLVR AVAPNFIPIW LRFLHSLDLK
MQADLALTQT MLRDFLTSGL SQVISSMSRS YVSLTGMSPS LAEYQVKTSK NRGIASQEVE
SLPKKDKGAS QRLHDALGLV LQELQTTASV VLRDLSHDTQ LDMENCELSI KLLPYARYLR
SAMFQESFDH SAVQVISKWM DDALRGSRPA FSRLAHAARL LEDAVSLTSG QGISQIWSTF
FNRKASSIPS SDLKRLENAA CLIILVNLNV LDIRREVLHL MAASTVDTIP LSKEQSIITD
LVDRLGQHLS DDRNDRSRQC HDDPCLLIIE LFVLSQANSD LSSISSCFKE SFPGVVFSGV
HQQGEEGYIA PLTTLLSFCE QATNSAFLRA FQRFLKPALY HMATQHQSAS NELSALGRCW
IALSRFILEL FVPNVPVDPS SFIRCSSDFW RHEEALLLHQ LNLHFDLERQ TTSNGSNSVI
RHLNDSLAEV RERLDNYSTD IPHRPDIARL HMFWSEVQQF LAHVLSPPKI DALLLHLESG
DPSTFVREEV VQESISAFCQ RLDMIYPDFQ DIAIVIQLAL LHMRLGLRLA RCSAQLSADT
AAEPSAKLAK ALISFPSVQS ADMLRTLGES TPHTCMSALE HILLNLSATA VKTSLEDITE
YTDDIELAYE QIFRLWRIDR TRADGLDRES QSLYRRSGLD HDATAEAVAE EQDFLELFPT
FEDVLEEENQ SRSQINYKEN SCLVNVLQVE QLLGIHYTLF ELPPVFDVGF MSSTSVKFRQ
ARRVALSSLL ETSSSSLPDI LDSMSLPLQF MLLQDQLSEL KEAPIPSKAF NFYTDANLIE
AQKATLVLEA LRTRLTVLGE DWPDQMVLQH LKSRCETILA FDFRCPIAKI LSALEQLLVQ
TNDWEMYAHR ENNLKSHQHA LTSLIIDWRR LELSCWQTLL RSHSDSFAST VSEYWFHLYE
VTVQGTLAAV DEGSEVSADY LRQLTNLLDD FICSSPIGQF QPRMRLLASF GSFVSKLMVT
KAKMYGSALE RVQLILKSTW RYYQLFSLRL STYLEDQRST LEKEVEGFIK LASWKDVNVQ
ALKQSAQRTH HNLYKIIRKY RDTLRQPIAD RLLPVFAGDG ECQLMETTRT RQSSPPPLLS
TSLSISGKPA LLGPAYLTNL AGTLQKFETF IESRVQTFLQ QYQAQVVDQM AVDVIVTSQN
LANEVVPPSL SQEKRRKYGK TILVRKRRAW SDLLKELKRM GLSANLKPEM LCLLRDDSWI
RQQPIMATAS DSIFVEKGEV YFDRLRGALP SLRALLPNHH SDIATRDLLR GITLLESGYS
LALDGRNRYV LFFSYRKALI LSLRLARTLA SFQELHKISK RLEILAQAPK FTKFGHSLFA
ELRSILNTLN KASHALDELA EGVETFDNLN TECTVTALAK KAKSICICTT AFPLVDEHMF
VLDVVRHLRG LPIQLNEMLA AEPRLHYLLH PVENWISEQG IPTLLPSDLS RTLEGNETNV
FIDVLLINVQ TMLSHCPTTC EVKPSEPTPD GFIRNGLRIM SQFTSLLDVN GVVEKVRTAA
DQLSGSSQSD TQERLKYILP FLRRYTDFAQ EQLMALAEWI KALFKLCFVL CSVMHNVAKQ
GFCTPPDVED SGSGPDSGEA TGGVGLGEGA GSENVSKEIE DESQVEGLKG DDAEDAAQKE
HGDDKDAIEM GDDFGGEMED VPDTGSQDEG SDSESDQELD EQIEDLGPSD PSAVDEKLWG
DESGPDSNEM DQTQQDRSTA NEDNSDVVAK EEKEEKQRDK PIDSKKEEET REGDSMDDVG
DDAANSEHDQ EDKDSDFPNA NGAPIDNHIP DADTLDLPED MKLEDDLQGP PDAEDIASED
EGQLDENTDV PMKDDTPHDG SEPLDEDDVM EPPHNMEGDD TRDEGDNEMD AGAVAQPDLS
AGEGESGMDD PTQGQDGSTE PQTSGSSGEM KPDDMEPKAS ENALEQTGGP EEQSRNDLLD
ASQAVETSTS ATQRGEGSSQ ESNDLANNPM RNLGDALKEI QQRFQEIFDG DASVKEPIKQ
SDKPPDQVEY DYSENVDHDM QALGPAGEEQ VAKLNDLKLV DHDQPKDEAG AAMDMDISPT
EQQEKIQPIS SLHAKPSTEG VQDDVEGAIA QIESRSNGSK EPLPSVPDAS LMKAESDMDD
SEEVTFDRAE AELRTWQAQS YSEDGAERIW RLYETLTHDL SYALCEQLRL ILEPTMATRL
KGDYRTGKRL NMKKIIPYIA SDYTKDKIWL RRTRPSQREY QILIALDDSR SMAESHSVHL
AYETLALVSK ALSRLEVGDI AIAKFGEAVD IIHGFDEGPF TDQAGTKVVN AFRFDQKATN
VLSLVETSLK VLEVAREGRS MRSASAADLW QLEIIISDGI CQDHDRLRAM LRRAAGQRVM
IVFIVIDSLH SAAGSTDNRT SSELAGSQNS ILSMNQVAYK MVDGRMELQM ERYMDSFPFD
YYVVLRSVEA LPEVLSGTLR QFFERISEE
//
