ID F8RBU3_MACFA Unreviewed; 255 AA.
AC F8RBU3;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=MHC class II Protein {ECO:0000313|EMBL:VDQ67961.1};
DE SubName: Full=MHC class II antigen {ECO:0000313|EMBL:AEI83896.1};
GN Name=Mafa-DQA {ECO:0000313|EMBL:AEI83896.1};
GN Synonyms=Mafa-DQA1 {ECO:0000313|EMBL:VDQ67961.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|EMBL:AEI83896.1};
RN [1] {ECO:0000313|EMBL:AEI83896.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21614582; DOI=10.1007/s00251-011-0537-5;
RA Creager H.M., Becker E.A., Sandman K.K., Karl J.A., Lank S.M., Bimber B.N.,
RA Wiseman R.W., Hughes A.L., O'Connor S.L., O'Connor D.H.;
RT "Characterization of full-length MHC class II sequences in Indonesian and
RT Vietnamese cynomolgus macaques.";
RL Immunogenetics 63:611-618(2011).
RN [2] {ECO:0000313|EMBL:VDQ67961.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AC349 {ECO:0000313|EMBL:VDQ67961.1};
RA Otting N.;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the MHC class II family.
CC {ECO:0000256|RuleBase:RU004238}.
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DR EMBL; HM580050; AEI83896.1; -; mRNA.
DR EMBL; LR131233; VDQ67961.1; -; mRNA.
DR RefSeq; NP_001271763.1; NM_001284834.1.
DR AlphaFoldDB; F8RBU3; -.
DR GeneID; 102132662; -.
DR OrthoDB; 4118190at2759; -.
DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW.
DR CDD; cd21008; IgC1_MHC_II_alpha_HLA-DQ; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR001003; MHC_II_a_N.
DR PANTHER; PTHR19944:SF59; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN; 1.
DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00993; MHC_II_alpha; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00920; MHC_II_alpha; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW MHC II {ECO:0000256|ARBA:ARBA00023182};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..255
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033697335"
FT TRANSMEM 222..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 113..193
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 255 AA; 28011 MW; 62BDAA78ED07BBC9 CRC64;
MILNKALMLG ALALTTMMSP CGGEDIVADH VASCGVNLYQ TYGLSGQFTH EFDGDEQFYV
DLRRKETAWR WPELSKFGGF DPQGALRNLA VLKHNLNIVT KRYNSTAATN EVPEVTVFSK
SPVTLGHPNT LICLVDNIFP PVVNITWLSN GRSVTEGVSE TSFLSKSDHS FFKISYLTFL
PSADEIYDCR VEHWGLDEPL LKHWEPEIPA PMSELTETVV CALGLSVGLV GIVVGTVFII
QGLRSVGASR HQGPL
//
