ID F8SN96_9SAUR Unreviewed; 213 AA.
AC F8SN96;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:AEH25685.1};
OS Morethia ruficauda (Lined firetail skink).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Scinciformata; Scincidae;
OC Eugongylinae; Morethia.
OX NCBI_TaxID=394149 {ECO:0000313|EMBL:AEH25685.1};
RN [1] {ECO:0000313|EMBL:AEH25685.1}
RP NUCLEOTIDE SEQUENCE.
RA Skinner A., Hugall A.F., Hutchinson M.N.;
RT "Lygosomine phylogeny and the origins of Australian scincid lizards.";
RL J. Biogeogr. 38:1044-1058(2011).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|ARBA:ARBA00002323, ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; HQ655178; AEH25685.1; -; Genomic_DNA.
DR AlphaFoldDB; F8SN96; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 105..212
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 113..180
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 158..209
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 168..211
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEH25685.1"
FT NON_TER 213
FT /evidence="ECO:0000313|EMBL:AEH25685.1"
SQ SEQUENCE 213 AA; 23993 MW; 02BFBD3788E8FDD5 CRC64;
GQGSLAYPGL RTQGTLENFG GPNDASRGLT SLADTFEHVI EELLDEQEVI QPSKENKDAD
LYSSRVMLSS QVPLEPPLLF LLEEYKNYLD AANMSMRVRR HSDPARRGEL SVCDSTSEWV
TAAEKKTAVD MSGATVTVLE NVPVPKGQLK QYFYETKCNS KGYTKEGCRG IDKRYWNSQC
RTTQSYVRAL TMDNKKRVGW RFIRIDTSCV CTL
//
