ID   F8STX5_AMYOR            Unreviewed;      1858 AA.
AC   F8STX5;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Peptide synthetase {ECO:0000313|EMBL:AEI58867.1};
GN   Name=vcm4 {ECO:0000313|EMBL:AEI58867.1};
OS   Amycolatopsis orientalis (Nocardia orientalis).
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Amycolatopsis.
OX   NCBI_TaxID=31958 {ECO:0000313|EMBL:AEI58867.1};
RN   [1] {ECO:0000313|EMBL:AEI58867.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HCCB10007 {ECO:0000313|EMBL:AEI58867.1};
RA   Huang H., Ge M., Jiang W., Zhu L., Ruan L., Luo M., Yang Y., Wei W.,
RA   Yang S., Chen D.;
RT   "Identification and analysis of the vancomycin biosynthetic gene cluster in
RT   Amycolatopsis orientalis HCCB10007.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HQ679900; AEI58867.1; -; Genomic_DNA.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd12117; A_NRPS_Srf_like; 1.
DR   CDD; cd19543; DCL_NRPS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.980; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR001031; Thioesterase.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   Pfam; PF00668; Condensation; 2.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SMART; SM00824; PKS_TE; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 1.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          964..1039
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   1858 AA;  199719 MW;  72E0D3995A4F3A1F CRC64;
     MTVDDTRAKP RSSVEDVWPL SPLQEGMLFH TALDKDGPDT YTVQTVYGID GPLDAGRLKA
     SWQALVDRHA ALRACFRYVS GAQMVQVIAR DAEIPWRETD LSGLAADAVE AEVDRLAAAE
     VAERLSVETA PLMKLHLIRL GEESHRLVHT LHHVLTDGWS MPIIHRELAE IYAAGGDASG
     LPPTVSYRDY LAWLGRQDKE AAKAAWRNEL AGLDTPTLVV PADPARVPDI HTTVVELSAE
     LTDGLARLAR GHGLTLNSVV QGAWAVVLSQ LAGRTDVVFG ATASGRPADL PGVESMVGQL
     LNTLPVRVRL DGAKRAVDLF DEVQRGQAAL MAHQYLGLQD VRSVAGPGAV FDTLVIYENF
     PRKGLGKPSG DGLNLLPLKR GSNSSHYPFT LVTGPGERMP LILDYDRGLF DPAAAESVVG
     AMARVLERLV AEPDVLVGRL TLASEAERAL VVDGFNATAG PVPGDSVVEL FARRVAGAPD
     AVAIIDAGGA NLTYAEVDQA SDRLAGYLAG RGVGRGDRVG VAMERSPELP IAFLAIWKAG
     AAYVPVDIEY PAERISFILA DSGVSTVLCT EATKAVAPED AIVLDAPGTR AAVDGCAAPG
     IRPHADDLAY VMYTSGSTGL PKGVGIPHGA VAGLAGDPGW QIGEDDGVLM HATHVFDPSL
     YAMWVPLVSG ARVLLTEPGV LDAAGVRQAV RRGATYVHLT AGTFRALAET SPECFEGLIE
     IGTGGDVVPL QSVENLRRAQ PGLRVRNTYG PTETTLCATW LPIEPGAVLG SELPIGHPMT
     NRRIYVLDAF LRPVAPGVAG ELYIAGTGLA RGYLNNPGLT ADRFVACPFL PGERMYRTGD
     LARWTRDGEI VFLGRADDQV KIRGYRVELG EVEAVLAAQP GVVEAVLLAR EDQPGEKRLV
     GYFVSDGTDA GPEEIRRRMG LVLPDYMVPI AVVALPGLPV TPNGKVDRRA LPAPDLAGRS
     SEKAPESETE KVLCALFAEI LSVEQVGVDD AFNDLGGSSA LAMRLVARIR EELGEDLPIR
     QLFSSPTPAG LARALAAKSR PVLEAAKRPD RVPLTARQLR AWLLADPGGE TAGLTTSVAL
     RLHGKLNVPA LVTALGDVAE RHELLRTTFP GDAQSVHQLV HDTPAAGPVP IPVTEEALPG
     LLAERREAAF DLTREVPWRC DLFELSEKEH VLHLQVHRIL ADDDSLDVFF RDLAAAYGAR
     REGRVPQRAP LALQFADYAL WERRLLEDEN EPGSLINEQF AFWRENLAGI DGETVLPFDR
     PRPAVPSRRA GTVALRLDAG PHARLTEAAE SAGVETSRLV HAALAMLLAK YGAGEDVVIG
     SALPRDEELF DLEPMVGPFT RPLAVRTDLS GDPTHREVVN RVQEAFQATE QHLDVPFERI
     VELLELPASL SRHPVFQVGL RVDEEDIDGW TAAELPALRT GVEPGGVEAM ELDLSVELTE
     LFDDDDEPGG FEGVLRYATD LFDEATAESV ARRLVRVLEQ VAEDPGRRIS ELDLFLDDFE
     RSRPPIAPAR WAGAVPQVVA DVAGDGPLGA LVLDERSRPV APGTVGELYV TGPAVDEGPA
     DLPTVPCPFG EEGHRMLRTG LLARKTPAKT LVVVGERRRT SSSVKTGDFE ILLPLRTTGD
     RPPLFCVHAS GGLSWNYEPL LRHLPSNQPV YGVQARGLAR TEPLPGSVEE MAADYLAQIR
     AVQPEGPYHL LGWSLGGRIA QAMAKLLEEE GEKVGLLALL DAYPVYMGRK TTGAASEEEA
     LSKRNQADLD LAGQLVKGEA ARARLEAVMR NLWDVGPRHV SSPFAGDILL FVATVDRPEH
     LPVSVAKASW KDFTSGTIET HDVPSNHYDM VQTAALGQIG AIVAEKLRQR PEGERTQR
//