ID   F8TEL7_9CLOT            Unreviewed;       357 AA.
AC   F8TEL7;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   SubName: Full=2,3-butanediol dehydrogenase {ECO:0000313|EMBL:AEI90715.1};
OS   Clostridium autoethanogenum.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=84023 {ECO:0000313|EMBL:AEI90715.1};
RN   [1] {ECO:0000313|EMBL:AEI90715.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 10061 {ECO:0000313|EMBL:AEI90715.1};
RX   PubMed=21685168; DOI=10.1128/AEM.00355-11;
RA   Kopke M., Mihalcea C., Liew F., Tizard J.H., Ali M.S., Conolly J.J.,
RA   Al-Sinawi B., Simpson S.D.;
RT   "2,3-butanediol production by acetogenic bacteria, an alternative route to
RT   chemical synthesis, using industrial waste gas.";
RL   Appl. Environ. Microbiol. 77:5467-5475(2011).
RN   [2] {ECO:0000313|EMBL:AEI90715.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 10061 {ECO:0000313|EMBL:AEI90715.1};
RA   Koepke M., Mihalcea C., Liew F.M., Tizard J., Ali M., Conolly J.,
RA   Al-Sinawi B., Simpson S.D.;
RL   Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; HQ876009; AEI90715.1; -; Genomic_DNA.
DR   AlphaFoldDB; F8TEL7; -.
DR   SMR; F8TEL7; -.
DR   BRENDA; 1.1.1.4; 14191.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08233; butanediol_DH_like; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR43161:SF23; (R,R)-BUTANEDIOL DEHYDROGENASE-RELATED; 1.
DR   PANTHER; PTHR43161; SORBITOL DEHYDROGENASE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          10..350
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   357 AA;  38675 MW;  C67E43B6CEFC4971 CRC64;
     MKAVLWYDKK DVRVEEIEEP KVKENAVKIK VKWCGICGSD LHEYLGGPIF IPVGTPHPLS
     KSTAPVVLGH EFSGEVVEIG SKVTKFKAGD RVIVEPIVAC GKCPACLEGK YNLCEALGFH
     GLCGSGGGFA EYTVFPEDFV HKIPDTMDYE KAALVEPMAV ALHSLRVGNF TTGNTALVLG
     AGPIGLATIQ CLKASGARIV IVFQRKSVRQ EYAKKFGADV VLDPNEVDVI EEIKKLTGGV
     GVDTSFETTG ANVGINTAIQ ALKYEGTAVI TSVWEKNAEI NPNDLVFTEK KVVGTLAYRH
     EFPSTIALMN DGRIKTDGYI TKRIALEDIV KEGFETLTGP EKKKHVKIIV TPDKSLL
//