ID F8VZH2_HUMAN Unreviewed; 137 AA.
AC F8VZH2;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 8.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=TGFB induced factor homeobox 1 {ECO:0000313|Ensembl:ENSP00000446838.1};
DE Flags: Fragment;
GN Name=TGIF1 {ECO:0000313|Ensembl:ENSP00000446838.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000446838.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000446838.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [2] {ECO:0000313|Ensembl:ENSP00000446838.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
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DR EMBL; AP001025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF456343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F8VZH2; -.
DR SMR; F8VZH2; -.
DR MassIVE; F8VZH2; -.
DR PeptideAtlas; F8VZH2; -.
DR ProteomicsDB; 29329; -.
DR Antibodypedia; 3890; 441 antibodies from 33 providers.
DR Ensembl; ENST00000551333.1; ENSP00000446838.1; ENSG00000177426.22.
DR UCSC; uc060myh.1; human.
DR HGNC; HGNC:11776; TGIF1.
DR VEuPathDB; HostDB:ENSG00000177426; -.
DR GeneTree; ENSGT00940000155230; -.
DR OMA; FPLCQSV; -.
DR ChiTaRS; TGIF1; human.
DR Proteomes; UP000005640; Chromosome 18.
DR Bgee; ENSG00000177426; Expressed in stromal cell of endometrium and 185 other cell types or tissues.
DR ExpressionAtlas; F8VZH2; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR PANTHER; PTHR11850:SF59; HOMEOBOX PROTEIN TGIF1; 1.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Proteomics identification {ECO:0007829|EPD:F8VZH2,
KW ECO:0007829|MaxQB:F8VZH2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 13..76
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 15..77
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 137
FT /evidence="ECO:0000313|Ensembl:ENSP00000446838.1"
SQ SEQUENCE 137 AA; 15542 MW; 2D86463562E3A3E8 CRC64;
MDIPLDLSSS AGSGKRRRRG NLPKESVQIL RDWLYEHRYN AYPSEQEKAL LSQQTHLSTL
QVCNWFINAR RRLLPDMLRK DGKDPNQFTI SRRGAKISET SSVESVMGIK NFMPALEETP
FHSCTAGPNP TLGRPLS
//
