ID F8W2X9_DANRE Unreviewed; 2271 AA.
AC F8W2X9; A0A8M1NHI3;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=ATP-binding cassette, sub-family A (ABC1), member 1B {ECO:0000313|Ensembl:ENSDARP00000124570, ECO:0000313|RefSeq:NP_001108058.2};
GN Name=abca1b {ECO:0000313|Ensembl:ENSDARP00000124570,
GN ECO:0000313|RefSeq:NP_001108058.2,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-9826};
GN Synonyms=im:7136239 {ECO:0000313|RefSeq:NP_001108058.2}, sb:cb407
GN {ECO:0000313|RefSeq:NP_001108058.2}, wu:fa07e06
GN {ECO:0000313|RefSeq:NP_001108058.2}, zgc:171581
GN {ECO:0000313|RefSeq:NP_001108058.2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000124570};
RN [1] {ECO:0000313|RefSeq:NP_001108058.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001108058.2};
RX PubMed=16124856;
RA Dean M., Annilo T.;
RT "Evolution of the ATP-binding cassette (ABC) transporter superfamily in
RT vertebrates.";
RL Annu. Rev. Genomics Hum. Genet. 6:123-142(2005).
RN [2] {ECO:0000313|RefSeq:NP_001108058.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001108058.2};
RX PubMed=16631343; DOI=10.1016/j.ygeno.2006.03.001;
RA Annilo T., Chen Z.Q., Shulenin S., Costantino J., Thomas L., Lou H.,
RA Stefanov S., Dean M.;
RT "Evolution of the vertebrate ABC gene family: analysis of gene birth and
RT death.";
RL Genomics 88:1-11(2006).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000124570}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000124570};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSDARP00000124570, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000124570};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_001108058.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001108058.2};
RX PubMed=25201834;
RA O'Hare E.A., Wang X., Montasser M.E., Chang Y.P., Mitchell B.D.,
RA Zaghloul N.A.;
RT "Disruption of ldlr causes increased LDL-c and vascular lipid accumulation
RT in a zebrafish model of hypercholesterolemia.";
RL J. Lipid Res. 55:2242-2253(2014).
RN [6] {ECO:0000313|RefSeq:NP_001108058.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001108058.2};
RX PubMed=26047617; DOI=10.1186/s12864-015-1677-z;
RA Ren J., Chung-Davidson Y.W., Yeh C.Y., Scott C., Brown T., Li W.;
RT "Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene
RT family in sea lamprey and Japanese lamprey.";
RL BMC Genomics 16:436-436(2015).
RN [7] {ECO:0000313|RefSeq:NP_001108058.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001108058.2};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [8] {ECO:0000313|RefSeq:NP_001108058.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001108058.2};
RX PubMed=28536535;
RA Benitez-Santana T., Hugo S.E., Schlegel A.;
RT "Role of Intestinal LXRalpha in Regulating Post-prandial Lipid Excursion
RT and Diet-Induced Hypercholesterolemia and Hepatic Lipid Accumulation.";
RL Front. Physiol. 8:280-280(2017).
RN [9] {ECO:0000313|RefSeq:NP_001108058.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001108058.2};
RX PubMed=29161261;
RA Anderson J.L., Mulligan T.S., Shen M.C., Wang H., Scahill C.M., Tan F.J.,
RA Du S.J., Busch-Nentwich E.M., Farber S.A.;
RT "mRNA processing in mutant zebrafish lines generated by chemical and
RT CRISPR-mediated mutagenesis produces unexpected transcripts that escape
RT nonsense-mediated decay.";
RL PLoS Genet. 13:e1007105-e1007105(2017).
RN [10] {ECO:0000313|RefSeq:NP_001108058.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001108058.2};
RX PubMed=28694436;
RA Foulkes M.J., Henry K.M., Rougeot J., Hooper-Greenhill E., Loynes C.A.,
RA Jeffrey P., Fleming A., Savage C.O., Meijer A.H., Jones S., Renshaw S.A.;
RT "Expression and regulation of drug transporters in vertebrate
RT neutrophils.";
RL Sci. Rep. 7:4967-4967(2017).
RN [11] {ECO:0000313|RefSeq:NP_001108058.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001108058.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CT009487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001108058.2; NM_001114586.2.
DR Ensembl; ENSDART00000148461; ENSDARP00000124570; ENSDARG00000079009.
DR Ensembl; ENSDART00000148461.3; ENSDARP00000124570.2; ENSDARG00000079009.6.
DR GeneID; 100136868; -.
DR KEGG; dre:100136868; -.
DR AGR; ZFIN:ZDB-GENE-030131-9826; -.
DR CTD; 100136868; -.
DR ZFIN; ZDB-GENE-030131-9826; abca1b.
DR HOGENOM; CLU_000604_19_0_1; -.
DR OrthoDB; 6951at2759; -.
DR Proteomes; UP000000437; Chromosome 14.
DR Bgee; ENSDARG00000079009; Expressed in gastrula and 30 other cell types or tissues.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0090554; F:phosphatidylcholine floppase activity; IBA:GO_Central.
DR GO; GO:0090556; F:phosphatidylserine floppase activity; IBA:GO_Central.
DR GO; GO:0033700; P:phospholipid efflux; IBA:GO_Central.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR PANTHER; PTHR19229:SF248; ATP-BINDING CASSETTE, SUB-FAMILY A (ABC1), MEMBER 1B ISOFORM X1; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840,
KW ECO:0000313|RefSeq:NP_001108058.2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F8W2X9};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 719..739
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 746..764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 776..800
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 821..845
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1354..1375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1664..1686
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1706..1732
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1744..1763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1775..1799
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1862..1884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 902..1133
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1921..2153
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1295..1319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1295..1315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2271 AA; 254297 MW; 32F80C499198D161 CRC64;
MSISTQLGLL LWKNFTYRRR QTLQLLTEIV WPLFIFFILI AVRLYYPPYE QHECHFPNKA
MPSAGTLPWI QGIVCNANNP CFRHPTPGES PGVVGNFNDS IISRLFSDAK KILLYSQNDK
SLDGFKELID AVKVMQNNTA GFKLKDFLHE DETLSTFLLQ NASFTENYVT NILDADVNLE
KVLIKGFGVH LRDMCSSIKL EDFVTIPDTS VARFTQDMIC RSPKNWLDQA ESHFKSNLDF
LKPVRSEIRT NATDVRKVTK ATDNLLESLG SLAVELASMR SWSDLRNEIL FLTENATGSP
SLMYQAVSRI VCGHPEGGGL KIKSLNWYED SNFQALFGNH NDSDDQPVPV YDNTTTPYCN
SMMRNMEASP ISRMIWRALK PLLMGKILYT PHSPATQKII HEVNKTFQEL GILRDLGGMW
EEARPKVWNF MENSNEMDLM RTLLLNNLTA NFFSAQLAGT QWSVEDVISF LSKHSEDTRP
QGTAFTWRDV FNETDQAIMS ISRFMECVNL DKLEPVSTEE KLVNESMSLL DNRKFWAGIV
FLDIPSNSSE LPPNVNYKIR MDIDNVERTN KIKDGYWDPG PRADPFEDLR YIWGGFSYLQ
DVVEHSIIRA VTGSKEKTGV YIQQMPYPCY VDDIFLRIMS RSMPLFMTLA WMYSVAIIIK
GVVYEKEARL KETMRIMGLD NGILWFSWFI SSLIPLLISA GLLVLLLKMG NLLPYSDPGV
VFLFLGSFAV VTIMQCFLIS TAFARANLAA ACGGIIYFTL YLPYVLCVAW QDYVGFAAKV
IASLLSPVAF GFGCEYFALF EEQGVGIQWN NLFSSPVEED DYNLTTCLIL MYFDAFLYGV
MTWYIETVFP GQYGIPRPWY FPFTKSYWFG ENSTNNTAIH GKKSNAGAVC IEEEPTHLKL
GVYIENLVKV YRHGKKLAVD GLTLGFHEGQ ITSFLGHNGA GKTTTMSILT GLFPPTSGTA
YIMGKDIRSE LSSIRQSLGV CPQHNVLFSM LTVEEHIWFY ARLKGLSEEE VKAEMEQILS
DTGLPHKRKS RTSQLSGGMQ RKLSVALAFV GGSKVVILDE PTAGVDPYAR RGIWDLLLKY
RAGRTILLST HHMDEADILG DRIAIISHGK LCCVGSSLFL KTQLGTGYYL TLVKKNTEPS
LSSCRNSSST VSFVKKDDNA SESSSDAGLG SDQESEAATA IVDVTIISRL ILKHVPAARM
VEDQGHEITY VLPYESAKNG AFVELFHDLD DRLADLGISS YGVSDTTLEE IFLKVAEDSG
VDTEMLSDGT LPVRRQRRHA FGADHQSCLK PLTEDDSFDC NESEGDPESK ETDYLSGSDG
KGSYQVKGWS LKRQQFVALL WKRLLYARRS RKGFFAQIVL PAVFVCIALV FSLIVPPFGK
YPSLALNPWM YEEQFMFFSE DAPYDVSTHK LLRALFDDPG FGTRCMKGES IPDAPCTMGD
EEWSTPEVPE SIIEILTTRN WTMNDPSPAC ECSCNGKKKM LPECPAGAGG LPPPQIKISE
TETLQNLTGR NISDYLVKTY AQIIGKSLKN KIWVNEFRYG GFSLGARSTQ VLPPAEEIDD
AISRVREIFQ LGKDSGSAAD RFLKSLSAFI NGLDTKNNVK IWFNNKGWHS IGAFLNVMNN
GILRANLPPG KDPSEFGITA YNHPLNLTKE QLSQVALMTT SVDVLVSICV IFAMSFVPAS
FVVFLIQERV NKAKHMQFIS GVQPYLYWLA NFLWDMCNYV VPATLVILIF VCFQQKAYVS
ATNLPVLALL LLLYGWSITP LMYPASFLFK IPSTAYVVLT SVNILIGING SISTFVMELF
GNHEIGGIND ILKNVLLIFP HFCLGRGLID MVKNQAMADA LERFGENRFR SPLEWDMVGK
NLFAMAVEGV VFFIITVLIQ YRFFFEPKSL CPKLSPIGEE DEDVARERQR IMSGAGQGDI
LELRQLTKVY KRKQKPAVDR LCVGIPPGEC FGLLGVNGAG KTSTFKMLTG DSVVTKGEAF
IAGKSILREI DEVHQNMGYC PQFDAINDLL TGREHLEFYA ILRGVPENEV CAVAEWGIRK
LGLVKYVDKN AGSYSGGNMR KLSTAISLIG APPVVFLDEP TTGMDPKARR ALWNCIHSVI
KEGRSVVLTS HSMEECEALC TRMAIMVNGR FRCLGSVQHL KNRFGDGYTI ILRVAGPDPD
LQPVMKFIES ELPGSTLKEK HRNMLQYQLP SSLTSLAHIF SILAKNKEFL RIEDYSVSQT
TLDQVFVNFA KDQSDDHSDS SISRKGTAVN MALLTPLSTK DSLEKPMESF V
//
