ID F8W703_HUMAN Unreviewed; 1443 AA.
AC F8W703;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 12-OCT-2022, sequence version 2.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Roundabout guidance receptor 2 {ECO:0000313|Ensembl:ENSP00000327536.9};
GN Name=ROBO2 {ECO:0000313|Ensembl:ENSP00000327536.9};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000327536.9, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000327536.9, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000327536.9}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC016942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC024256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC026877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC067717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC117514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC126467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC130004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC131154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KC876890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001276969.1; NM_001290040.1.
DR SMR; F8W703; -.
DR MassIVE; F8W703; -.
DR MaxQB; F8W703; -.
DR PeptideAtlas; F8W703; -.
DR ProteomicsDB; 29864; -.
DR Antibodypedia; 2693; 284 antibodies from 34 providers.
DR Ensembl; ENST00000332191.13; ENSP00000327536.9; ENSG00000185008.19.
DR GeneID; 6092; -.
DR UCSC; uc062lpp.1; human.
DR CTD; 6092; -.
DR HGNC; HGNC:10250; ROBO2.
DR VEuPathDB; HostDB:ENSG00000185008; -.
DR GeneTree; ENSGT00940000156324; -.
DR PhylomeDB; F8W703; -.
DR ChiTaRS; ROBO2; human.
DR Proteomes; UP000005640; Chromosome 3.
DR Bgee; ENSG00000185008; Expressed in ganglionic eminence and 145 other cell types or tissues.
DR ExpressionAtlas; F8W703; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 3.
DR CDD; cd07693; IgC_1_Robo; 1.
DR CDD; cd05726; IgI_4_Robo; 1.
DR CDD; cd20952; IgI_5_Robo; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF52; ROUNDABOUT HOMOLOG 2; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 1: Evidence at protein level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|MaxQB:F8W703,
KW ECO:0007829|PeptideAtlas:F8W703};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1443
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035731291"
FT TRANSMEM 864..886
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..127
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 133..220
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 225..309
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 318..413
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 421..508
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 528..622
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 641..739
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 743..840
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 607..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1036..1088
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1128..1160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1219..1288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1307..1443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1145..1160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1244..1270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1316..1349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1357..1378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1389..1408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1428..1443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1443 AA; 157778 MW; 0ACB7BB7E42D4234 CRC64;
MSLLMFTQLL LCGFLYVRVD GSRLRQEDFP PRIVEHPSDV IVSKGEPTTL NCKAEGRPTP
TIEWYKDGER VETDKDDPRS HRMLLPSGSL FFLRIVHGRR SKPDEGSYVC VARNYLGEAV
SRNASLEVAL LRDDFRQNPT DVVVAAGEPA ILECQPPRGH PEPTIYWKKD KVRIDDKEER
ISIRGGKLMI SNTRKSDAGM YTCVGTNMVG ERDSDPAELT VFERPTFLRR PINQVVLEEE
AVEFRCQVQG DPQPTVRWKK DDADLPRGRY DIKDDYTLRI KKTMSTDEGT YMCIAENRVG
KMEASATLTV RARPVAPPQF VVRPRDQIVA QGRTVTFPCE TKGNPQPAVF WQKEGSQNLL
FPNQPQQPNS RCSVSPTGDL TITNIQRSDA GYYICQALTV AGSILAKAQL EVTDVLTDRP
PPIILQGPAN QTLAVDGTAL LKCKATGDPL PVISWLKEGF TFPGRDPRAT IQEQGTLQIK
NLRISDTGTY TCVATSSSGE TSWSAVLDVT ESGATISKNY DLSDLPGPPS KPQVTDVTKN
SVTLSWQPGT PGTLPASAYI IEAFSQSVSN SWQTVANHVK TTLYTVRGLR PNTIYLFMVR
AINPQGLSDP SPMSDPVRTQ DISPPAQGVD HRQVQKELGD VLVRLHNPVV LTPTTVQVTW
TVDRQPQFIQ GYRVMYRQTS GLQATSSWQN LDAKVPTERS AVLVNLKKGV TYEIKVRPYF
NEFQGMDSES KTVRTTEEAP SAPPQSVTVL TVGSYNSTSI SVSWDPPPPD HQNGIIQEYK
IWCLGNETRF HINKTVDAAI RSVIIGGLFP GIQYRVEVAA STSAGVGVKS EPQPIIIGRR
NEVVITENNN SITEQITDVV KQPAFIAGIG GACWVILMGF SIWLYWRRKK RKGLSNYAVT
FQRGDGGLMS NGSRPGLLNA GDPSYPWLAD SWPATSLPVN NSNSGPNEIG NFGRGDVLPP
VPGQGDKTAT MLSDGAIYSS IDFTTKTSYN SSSQITQATP YATTQILHSN SIHELAVDLP
DPQWKSSIQQ KTDLMGFGYS LPDQNKGNNG GKGGKKKKNK NSSKPQKNNG STWANVPLPP
PPVQPLPGTE LEHYAVEQQE NGYDSDSWCP PLPVQTYLHQ GLEDELEEDD DRVPTPPVRG
VASSPAISFG QQSTATLTPS PREEMQPMLQ AHLDELTRAY QFDIAKQTWH IQSNNQPPQP
PVPPLGYVSG ALISDLETDV ADDDADDEEE ALEIPRPLRA LDQTPGSSMD NLDSSVTGSM
VNGWGSASDE DRNFSSHRSS VGSSSDGSIF ASGSFAQALV AAADKAGFRL DGTSLTRTGK
AFTSSQRPRP TSPFSTDSNT SAALSQSQRP RPTKKHKGGR MDQQPALPHR REGMTDEEAL
VPYSKPSFPS PGGHSSSGTA SSKGSTGPRK TEVLRAGHQR NASDLLDIGY MGSNSQGQFT
GEL
//
