ID F8W8T8_HUMAN Unreviewed; 858 AA.
AC F8W8T8;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Acetyl-CoA carboxylase beta {ECO:0000313|Ensembl:ENSP00000367085.6};
GN Name=ACACB {ECO:0000313|Ensembl:ENSP00000367085.6};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000367085.6, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000367085.6, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RG Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A., null.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [3] {ECO:0000313|Ensembl:ENSP00000367085.6}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC007637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F8W8T8; -.
DR SMR; F8W8T8; -.
DR MassIVE; F8W8T8; -.
DR MaxQB; F8W8T8; -.
DR PeptideAtlas; F8W8T8; -.
DR ProteomicsDB; 30205; -.
DR Antibodypedia; 1321; 185 antibodies from 30 providers.
DR Ensembl; ENST00000377854.9; ENSP00000367085.6; ENSG00000076555.16.
DR UCSC; uc058sxr.1; human.
DR HGNC; HGNC:85; ACACB.
DR VEuPathDB; HostDB:ENSG00000076555; -.
DR GeneTree; ENSGT00940000155049; -.
DR HOGENOM; CLU_327036_0_0_1; -.
DR ChiTaRS; ACACB; human.
DR Proteomes; UP000005640; Chromosome 12.
DR Bgee; ENSG00000076555; Expressed in tendon of biceps brachii and 208 other cell types or tissues.
DR ExpressionAtlas; F8W8T8; baseline and differential.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR Gene3D; 2.40.460.10; Biotin dependent carboxylase carboxyltransferase; 1.
DR InterPro; IPR049076; ACCA.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR013537; AcCoA_COase_cen.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR PANTHER; PTHR45728:SF1; ACETYL-COA CARBOXYLASE 2; 1.
DR PANTHER; PTHR45728; ACETYL-COA CARBOXYLASE, ISOFORM A; 1.
DR Pfam; PF08326; ACC_central; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:F8W8T8,
KW ECO:0007829|PeptideAtlas:F8W8T8};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 361..691
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 695..858
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
SQ SEQUENCE 858 AA; 97372 MW; 0ACCFDBC6C812B6F CRC64;
MTVPISITNP DLLRHSTELF MDSGFSPLCQ RMGAMVAFRR FEDFTRNFDE VISCFANVPK
DTPLFSEART SLYSEDDCKS LREEPIHILN VSIQCADHLE DEALVPILRT FVQSKKNILV
DYGLRRITFL IAQEKEFPKF FTFRARDEFA EDRIYRHLEP ALAFQLELNR MRNFDLTAVP
CANHKMHLYL GAAKVKEGVE VTDHRFFIRA IIRHSDLITK EASFEYLQNE GERLLLEAMD
ELEVAFNNTS VRTDCNHIFL NFVPTVIMDP FKIEESVRYM VMRYGSRLWK LRVLQAEVKI
NIRQTTTGSA VPIRLFITNE SGYYLDISLY KEVTDSRSGN IMFHSFGNKQ GPQHGMLINT
PYVTKDLLQA KRFQAQTLGT TYIYDFPEMF RQALFKLWGS PDKYPKDILT YTELVLDSQG
QLVEMNRLPG GNEVGMVAFK MRFKTQEYPE GRDVIVIGND ITFRIGSFGP GEDLLYLRAS
EMARAEGIPK IYVAANSGAR IGMAEEIKHM FHVAWVDPED PHKGFKYLYL TPQDYTRISS
LNSVHCKHIE EGGESRYMIT DIIGKDDGLG VENLRGSGMI AGESSLAYEE IVTISLVTCR
AIGIGAYLVR LGQRVIQVEN SHIILTGASA LNKVLGREVY TSNNQLGGVQ IMHYNGVSHI
TVPDDFEGVY TILEWLSYMP KDNHSPVPII TPTDPIDREI EFLPSRAPYD PRWMLAGRPH
PTLKGTWQSG FFDHGSFKEI MAPWAQTVVT GRARLGGIPV GVIAVETRTV EVAVPADPAN
LDSEAKIIQQ AGQVWFPDSA YKTAQAVKDF NREKLPLMIF ANWRGFSGGM KGCLGTWRDV
SWWKIRAMLP MHIGEGSV
//
