ID F8WCW6_HUMAN Unreviewed; 60 AA.
AC F8WCW6;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Chromobox 4 {ECO:0000313|Ensembl:ENSP00000415348.1};
GN Name=CBX4 {ECO:0000313|Ensembl:ENSP00000415348.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000415348.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000415348.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000415348.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AC100791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F8WCW6; -.
DR SMR; F8WCW6; -.
DR MassIVE; F8WCW6; -.
DR MaxQB; F8WCW6; -.
DR PeptideAtlas; F8WCW6; -.
DR ProteomicsDB; 31294; -.
DR Antibodypedia; 1793; 516 antibodies from 38 providers.
DR Ensembl; ENST00000448310.1; ENSP00000415348.1; ENSG00000141582.15.
DR UCSC; uc060kzt.1; human.
DR HGNC; HGNC:1554; CBX4.
DR VEuPathDB; HostDB:ENSG00000141582; -.
DR GeneTree; ENSGT00940000160081; -.
DR HOGENOM; CLU_193249_0_0_1; -.
DR ChiTaRS; CBX4; human.
DR Proteomes; UP000005640; Chromosome 17.
DR Bgee; ENSG00000141582; Expressed in upper leg skin and 181 other cell types or tissues.
DR ExpressionAtlas; F8WCW6; baseline and differential.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18627; CD_polycomb_like; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR043531; CBX4.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR017984; Chromo_dom_subgr.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR PANTHER; PTHR46727; E3 SUMO-PROTEIN LIGASE CBX4; 1.
DR PANTHER; PTHR46727:SF1; E3 SUMO-PROTEIN LIGASE CBX4; 1.
DR Pfam; PF00385; Chromo; 1.
DR PRINTS; PR00504; CHROMODOMAIN.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR PROSITE; PS00598; CHROMO_1; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:F8WCW6,
KW ECO:0007829|MaxQB:F8WCW6};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 11..60
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
SQ SEQUENCE 60 AA; 7155 MW; 5DEA3CE99C7E668A CRC64;
MELPAVGEHV FAVESIEKKR IRKGRVEYLV KWRGWSPKYN TWEPEENILD PRLLIAFQNS
//
