ID F8WEU1_HUMAN Unreviewed; 171 AA.
AC F8WEU1;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=SET domain and mariner transposase fusion gene {ECO:0000313|Ensembl:ENSP00000393044.1};
GN Name=SETMAR {ECO:0000313|Ensembl:ENSP00000393044.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000393044.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000393044.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000393044.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
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DR EMBL; AC023483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC034191; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F8WEU1; -.
DR SMR; F8WEU1; -.
DR MassIVE; F8WEU1; -.
DR MaxQB; F8WEU1; -.
DR PeptideAtlas; F8WEU1; -.
DR ProteomicsDB; 31957; -.
DR Ensembl; ENST00000413809.5; ENSP00000393044.1; ENSG00000170364.13.
DR UCSC; uc062gdj.1; human.
DR HGNC; HGNC:10762; SETMAR.
DR VEuPathDB; HostDB:ENSG00000170364; -.
DR GeneTree; ENSGT00440000033232; -.
DR HOGENOM; CLU_1562370_0_0_1; -.
DR Proteomes; UP000005640; Chromosome 3.
DR Bgee; ENSG00000170364; Expressed in body of uterus and 168 other cell types or tissues.
DR ExpressionAtlas; F8WEU1; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR46223:SF3; HISTONE H3 (LYS9) METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR46223; HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR SMART; SM00468; PreSET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50867; PRE_SET; 1.
PE 1: Evidence at protein level;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Proteomics identification {ECO:0007829|EPD:F8WEU1,
KW ECO:0007829|PeptideAtlas:F8WEU1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 73..136
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
SQ SEQUENCE 171 AA; 18905 MW; 8C49BE1360DD31AE CRC64;
MFAEAAKTTR PCGMAEFKEK PEAPTEQLDV ACGQENLPVG AWPPGAAPAP FQYTPDHVVG
PGADIDPTQI TFPGCICVKT PCLPGTCSCL RHGENYDDNS CLRDIGSGGK YAEPVFECNV
LCRCSDHCRN RVVQKGLQFH FQVFKTHKKG WGLRTLEFIP KGRKVEHQLW K
//
