ID F8WH29_MOUSE Unreviewed; 4247 AA.
AC F8WH29;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Polycystic kidney and hepatic disease 1-like 1 {ECO:0000313|Ensembl:ENSMUSP00000036988.6};
GN Name=Pkhd1l1 {ECO:0000313|Ensembl:ENSMUSP00000036988.6,
GN ECO:0000313|MGI:MGI:2183153};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000036988.6, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000036988.6, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000036988.6,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000036988.6}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000036988.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR SMR; F8WH29; -.
DR EPD; F8WH29; -.
DR MaxQB; F8WH29; -.
DR ProteomicsDB; 359632; -.
DR Antibodypedia; 26574; 19 antibodies from 9 providers.
DR Ensembl; ENSMUST00000038336.12; ENSMUSP00000036988.6; ENSMUSG00000038725.14.
DR AGR; MGI:2183153; -.
DR MGI; MGI:2183153; Pkhd1l1.
DR VEuPathDB; HostDB:ENSMUSG00000038725; -.
DR GeneTree; ENSGT00940000157594; -.
DR HOGENOM; CLU_000057_1_0_1; -.
DR OMA; RSFPQKM; -.
DR ChiTaRS; Pkhd1l1; mouse.
DR Proteomes; UP000000589; Chromosome 15.
DR Bgee; ENSMUSG00000038725; Expressed in ureteric bud trunk and 51 other cell types or tissues.
DR ExpressionAtlas; F8WH29; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00603; IPT_PCSR; 12.
DR Gene3D; 2.60.40.420; Cupredoxins - blue copper proteins; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 14.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 1.
DR InterPro; IPR008972; Cupredoxin.
DR InterPro; IPR019316; G8_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR037524; PA14/GLEYA.
DR InterPro; IPR011658; PA14_dom.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR PANTHER; PTHR46769:SF2; FIBROCYSTIN-L; 1.
DR PANTHER; PTHR46769; POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1; 1.
DR Pfam; PF10162; G8; 2.
DR Pfam; PF07691; PA14; 1.
DR Pfam; PF01833; TIG; 14.
DR SMART; SM01225; G8; 2.
DR SMART; SM00429; IPT; 10.
DR SMART; SM00758; PA14; 1.
DR SMART; SM00710; PbH1; 12.
DR SUPFAM; SSF56988; Anthrax protective antigen; 1.
DR SUPFAM; SSF49503; Cupredoxins; 1.
DR SUPFAM; SSF81296; E set domains; 14.
DR SUPFAM; SSF51126; Pectin lyase-like; 1.
DR PROSITE; PS51484; G8; 2.
DR PROSITE; PS51820; PA14; 1.
PE 1: Evidence at protein level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Proteomics identification {ECO:0007829|EPD:F8WH29,
KW ECO:0007829|PeptideAtlas:F8WH29};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..4247
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003385638"
FT DOMAIN 337..492
FT /note="PA14"
FT /evidence="ECO:0000259|PROSITE:PS51820"
FT DOMAIN 2183..2303
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
FT DOMAIN 3035..3173
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
FT REGION 4183..4208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4247 AA; 464505 MW; AAE92407B14814BD CRC64;
MGHLWLSGTW FLFGLLWCAA DSHKGSSETI PKVTEVIPKY GSINGATRLT IKGEGFSQAS
QFNYGADNTE LGNHVQLVSS FQSITCDVEK DSSHSTQITC YTRAMPEDTY SVRVSVDGVP
VAENNTCKGV ASSWACSFST KSFRTPTIRS ITPLSGTPGT LITIKGRLFT DVYGSNTALS
SNGRNVRILR IYIGGMPCEL LIPHSDDLYG LKLDHANGDT GSVTCKTTGT YIGHHNVSFI
LDSDYGRSFP EKMTYFVSSL NKISMFQTYP EVVMVSPSKG STEGGTLLTI HGHFFDQTDL
PVRVLVGGQA CAILNVTENT IYCKTPPKPH ILKATYPGGR GLKVEVWNNS RPAHLEDILE
YNEHTPGYMG ATWTDSASYV WPIEQDTFVA RISGFLVPPD SDVYRFYIRG DDRYAIYFSQ
TGRTEDKVRI AYYSGNANTY FSNSTQRSDE IHLQKGKEYY IEILLQEYTL SAFVDVGLYQ
YKNVFTEQQT GDALNEEQVI KSQSTVVPEV QIITLENWET ADVTNEVQQV TVTSPCVGAN
SCSLSQYRFI YNMEKTVWLP ADASDFTLKS ALNDLWSIKP DSVQVTSKRD LQSYIYTITF
VSTRGDFDLL GYEVFEGSNV TLSITEQTKG KPNLETFTLN WDGIASKPLT PESSEAEFQV
AVEEMVSAKC PPEIAHLEEG FLVKYFRDYE TDFELEHINR GQKTAETDAY CGRYSLKNPA
VLFDSTDVKP NKSPYGDILL FPYNQLCLAY KGSLANFIDL KFKYQDSGKI IRSADVQFEY
NFASGNKWTY TCIDLLDFLQ TKYAGTSFSL QRITLQKSSE FQSIYVDAVY IGQTPTVSVL
DDMPKRRPPA LANKGIFLKH FQVNRTKLNG SAMTIQYSVT ITSYNCSHNI PMMAVSFGQI
ITNETKNELV YRGNNWPGES KIRIQKIQEA SPPISGSFDV QAYGHTLKGI PAAVPAADLQ
FALQSLEEIE QVSVNREGTC AGYSWSIRWT SPRGKQPLLQ INDSNIIGEK ANVTVTTIKE
GGLFRQRIPG DMLRTLNQQP QVEVYVNGIP AKCSGDCGFT WDAMITPLIL TTTPSEGSYA
ESTILTIAGS GFSPTSAVSV SVGSTRCSLL SVEENEIKCQ ILNGSAGHVP VAVSIADVGL
AQNLEGEGSH FIYRSQISHV WPDSGSLAGG TLLTISGFGF SENSTVLVGN ETCNVIEGDL
NRITCRTSKR IEGTVDISVI TNGIQVTAKD SFSYSCLQTP VVTDFSPKER TVLGKVNLTI
KGYNFGNELA QNTVYVGRKH CQVLHSNFTD ITCLLPTLPP GKHDIYVKVR NWGLASTRNK
LNASILYILE VIHMFPQRGS LYGGTEITIM GFGFSTIPTE NSVLLGSFPC DITSSSENVI
KCTLHSTGTV FRITNNGSHL VHGLGYAWSP SVLNVTVGDT VVWSWQAHPF LRGIGYRIFS
VSSPGSVTYD DKGFTNGRQK SASGSFSYQF TSPGIYYYSS GYVDEAHSIS LQGVINVFPA
EARHIPLYLF VGNIEATYVP AGPAHLQLAS TAAGCLATEP LCGLNDTRVK HSNKLFFELS
NCISPSIINI TPSTGTANEL ITIIGHGFSS LPCANKVTIG SYPCVVEESS ENSIICHIDP
QNSMNVGIRE IVTLIVYNLG TAINTLTKAF DRRFVLLPNI DMVMPKAGST TGMTRVTIQG
SGFMSSPEGV EVFMGDFPCK VLSVTYTAIE CETSPAPQQL VLVDILIHGV PAQCQSNCSF
SYLENIAPYV TGIFPNSIQG YGNVLIKGER FGTVLEEISI FIGSQQFRVI DVNENNITVL
MTPLEAGLHS LSVVVGSKGL ALGNLTISSP AVASVSPTSG SIAGGTTLMI TGNGFSPGNT
TVTVGDQPCQ ITFISSSEVY CSTPAGRAGT ANLKISVNAI IYPPLSFTYA MEDTPFLKRI
IPNRGLPGTE VEITGSNLGF AISDVSVMIK ESVCNVTTVN DTVLQCTVGE HAGGIFPVTM
LHKTKGSAVS SVAFEYPLSI QNIYPTQGSF GGGQTLTVTG MGFDPWNSTI LVCNSECAVD
KLRSNSTTLF CVIPPNNGKG HDQVCGVSVV NGKDSSHSTK LFTYTLSLTP LITEISPRRG
STAGGTRLTV TGSGFSENTQ GVQVFVGNSK CDIQYSNKTH IVCMTSVHVP SGWVPVHVNI
KNIGLAKLEN ADFLYADVWS ANSSWGGSPP PEEGSLAVIT KGQIILLDQS TPILKMLLIQ
GGTLIFDEAN IELQAENILI TDGGVLQIGT EASPFQHRAV ITLHGHLRSP ELPVYGAKTL
GVREGTLDLH GLPIPVVWTR LTHTANAGEW TLTVQEAVTW KAGDNIVIAS TGHRHSQAEN
EKRTIASVSA DGMHITLTKP LNYTHLGITT TLPDGTVFEA RAEVGILTRN ILIRGSDNVE
WNDKIPSCPD GFDTGEFATQ TCLQGKFGEE MGSDQFGGCI MLHAPLPGAD MVTGRIEYVE
VFHAGQSFRL GRYPIHWHLL GDLQFKSYVK GCAIHQSYNR AITIHNTHHL LVERNIIYDI
KGGAFFIEDG IEHGNILQYN LAVFVQQSTS LLNDDVTPAA FWVTNPNNTI RHNAAAGGTH
FGFWYRMNDH PDGPSFDRNI CQKRIPLGEF FNNTVHSQGW FGLWIFEEYF PMQTGSCTST
VPVPAIFNSL TVWNCQKGAE WVNGGALQFH NFVMVNNNEA GIETKRILAP YVGGWGESNG
AVIKNAKIVG HLDELGMGPT FCTSKGLVLP FSQGLTVSSV HFMNFDRHAC VALGVTSITG
VCNDRCGGWS AKFVGIRYFH APNKGGFRWE HEAVLIDVDG SLTGHRGHTV VPHSSLLDPS
HCTQEPAWSI GFPGSICDAS VSFHRLAFNK PSPVSLLEKD VVLSDSFGTS IVPFQKKRLT
HMSGWMALIP NANHINWYFK GVEHLTNISY TSTFYGFKEE DYVIISHNFT QNPDMFNVVD
MRNGSANPLN WNSSKNGDWH LEANTSTLYY LVSGRSDLPQ SQPISGTLDP GVKDVIINFQ
AYCCVLQDCF PVHPPSRKPI PRKRPAAYNL WSNESFWQSS PENNYTVPRP GANVIIPEGT
WIVADVDIPP VERLIIWGVL EMEDKSEIGV AGPTYRRVVL NATYISVQGG RLIGGWEDNP
FKGELQIVLR GNHSTPEWAF PDGPNQGAKV LGVFGELDLH GLPHSVYKTK LLETAEAGSK
ILSLVDAVDW QEGEDVVITT TSYDLHQTEI RRIAKILHGH KILILNDSLS YTHLAERQWI
SGTAQSYTLS ADVGILSRNI KIVGDDYSVL SKDSFGARIL VGSFTGNMMT FKGNARISNV
EFHHSGQEGY RDSTDPRYAV TFLNLGQIQD HGLSYVRGCA FHHVFSPAIG VFGTDGVDID
DNIIYFTVGE GIRIWGDANR VRGNLVTLSV WPGTYQNRKD LSSTLWHAAI EINRGTNTVL
QNNVVAGFGR VGYRIDGEPC SSQANSMENW FNNEAHGGLY GIYMNQDGLP GCSLIQGFTI
WTCWDYGIYF QTTESVHIYN VTLVNNGMSI FSMVYMPPSV SHKISSKTVK IKNSLIVGSS
PEFNCSDVLT NDSPDVELTS AHRSSRPPSG GRSGICWPTF ASAHNMAPRK PHAGIMSYNA
ISGLLHVSDS TFVGFKDVCS GETNVIFITN PLNEDLQHPI HVKNVQLIDT IEQSKVFIHR
PDISKVNPSD CVDMVCDAKR KSFLRDLDGS FLGNSGSVIP QAEYEWDGNS QLGIGDYRIP
KAMLTYLNGS RIPVTEKAPH KGIIRDATCK YIPEWQSYQC SGMEYAMMVL ESLDSDTETR
RLSPVAIMSN GYVDLINGPQ DHGWCAGYTC QRRLSLFHGI VALNKKYEVY FTGTSPQNLR
LMLLNVEHNK AVLVGIFFST LQRLDVYVNN SLVCPKNTAW NAQKKHCELE RHLSTEQFLP
NLGSTVPGEN YFDRTYQMLY LFLKGTTPVE VHTATVIFVS FHLPVMTADE FFSSHNLVRN
LALFLKIPSD KIRVSRIIGA SLRKKRSTGH IMEFEIGAAP TQFLSNSTTG QMQLSELQEI
TDSLGQAVVL GKISTILGFN ISSMSITSPI PQPTDSGWIK VTAQPVERSA FPVHYLALVS
SLSVVAQPVA AQPGQPFPQQ PSVKAVDPEG NCVSVGITSL TLKAILKDSN NNQVGGLSGN
TTIPFSTCWA NYTDLTPHRT GKNYKIEFVL DNTVRVDSRP FSLSAQSVPG GSGSSPGSGS
SSSGHSKASS VGTPVQTLAV ITACLVGRLL LLEVFMAAVF ILNTTVG
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