ID F9EC72_9ACTO Unreviewed; 508 AA.
AC F9EC72;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Cardiolipin synthetase {ECO:0000313|EMBL:EGQ76169.1};
DE EC=2.7.8.- {ECO:0000313|EMBL:EGQ76169.1};
GN Name=cls {ECO:0000313|EMBL:EGQ76169.1};
GN ORFNames=HMPREF9062_0044 {ECO:0000313|EMBL:EGQ76169.1};
OS Actinomyces sp. oral taxon 448 str. F0400.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=888056 {ECO:0000313|EMBL:EGQ76169.1, ECO:0000313|Proteomes:UP000005351};
RN [1] {ECO:0000313|EMBL:EGQ76169.1, ECO:0000313|Proteomes:UP000005351}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0400 {ECO:0000313|EMBL:EGQ76169.1,
RC ECO:0000313|Proteomes:UP000005351};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGQ76169.1}.
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DR EMBL; AFQC01000002; EGQ76169.1; -; Genomic_DNA.
DR RefSeq; WP_009409574.1; NZ_GL985606.1.
DR AlphaFoldDB; F9EC72; -.
DR STRING; 888056.HMPREF9062_0044; -.
DR eggNOG; COG1502; Bacteria.
DR HOGENOM; CLU_038053_1_0_11; -.
DR OrthoDB; 9762009at2; -.
DR Proteomes; UP000005351; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030572; F:phosphatidyltransferase activity; IEA:UniProt.
DR GO; GO:0032049; P:cardiolipin biosynthetic process; IEA:UniProt.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR027379; CLS_N.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR PANTHER; PTHR21248; CARDIOLIPIN SYNTHASE; 1.
DR PANTHER; PTHR21248:SF22; PHOSPHOLIPASE D; 1.
DR Pfam; PF13091; PLDc_2; 2.
DR Pfam; PF13396; PLDc_N; 1.
DR SMART; SM00155; PLDc; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005351};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000313|EMBL:EGQ76169.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 38..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 216..243
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 421..448
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
SQ SEQUENCE 508 AA; 56933 MW; CCB323ABB7DF1A7B CRC64;
MEWPPFLATT WVVIEYAIKI VALGTIPENR RPASSTAWLL LIFLLPIVGL PLYIFLGSPW
IHGKRRRQQE EVNEIALEAT KDVPYAPDGP QRSLQLDSIL RMNRALTGLP CVTGDVVALH
ADSAATYAQM ARAVDAATHH VHVEFYIQSW DPVTDVFYRA LERAAARGVT VRLLIDHLGS
RKYPGWRDLG HRFTAAGIRW RLMMPLLPHK RRFRRPDLRN HRKLLVIDGE RAFIGSHNII
DPTYRLRSNV RAGRTWADLS VEVAGDIVVE AEAVFGMDWF FEAGEAFDME SILPQAGGSR
TVAQVLEDAA PVGTPAPQPG RPDAVVNAMQ LVPSGPGYPT EPNLRMVLSL IQNATERVSI
TSPYFVPDEA LLSAMTTAAY RGVEVELFVG RESDHLIVNH AQRSYYQALL ASGVRIYRYP
APTVLHAKYM TVDDEIAIIG SANMDFRSFA LNYEVMLLAF GGDLDDLLRA NDAHYRSVSL
ELTAEEWAAE PWWRRYIDNV CRLLSAVL
//
