ID F9EF70_9ACTO Unreviewed; 408 AA.
AC F9EF70;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Alcohol dehydrogenase {ECO:0000313|EMBL:EGQ74332.1};
DE EC=1.1.1.1 {ECO:0000313|EMBL:EGQ74332.1};
GN ORFNames=HMPREF9062_1092 {ECO:0000313|EMBL:EGQ74332.1};
OS Actinomyces sp. oral taxon 448 str. F0400.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=888056 {ECO:0000313|EMBL:EGQ74332.1, ECO:0000313|Proteomes:UP000005351};
RN [1] {ECO:0000313|EMBL:EGQ74332.1, ECO:0000313|Proteomes:UP000005351}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0400 {ECO:0000313|EMBL:EGQ74332.1,
RC ECO:0000313|Proteomes:UP000005351};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGQ74332.1}.
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DR EMBL; AFQC01000036; EGQ74332.1; -; Genomic_DNA.
DR AlphaFoldDB; F9EF70; -.
DR STRING; 888056.HMPREF9062_1092; -.
DR eggNOG; COG1062; Bacteria.
DR HOGENOM; CLU_026673_11_2_11; -.
DR Proteomes; UP000005351; Unassembled WGS sequence.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43350; NAD-DEPENDENT ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43350:SF2; PKS_ER DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:EGQ74332.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005351}.
FT DOMAIN 47..404
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 408 AA; 42499 MW; A537238E63AADB3D CRC64;
MRYPGHTGGP CPPPETLSES DSDMTSNEAV QSSPTIPETM RAAVLRDHDE GLRVETIRTP
RPKAGEVLIK VAACGLCHSD LHVIGGAIAF PLPAVLGHEV TGTIVEVGPG NEHTGLKTGQ
NVAGGFLMPC GQCDACASGY DELCGPFFDL NRLKGLLYDG TTRLATLEGD PISMYSMGGL
AEYAVVPSTS VTPVPERIDL VPAAILGCAA MTGYGAVRRG ADLRFGETVA VIATGGVGTN
IVQIARAFGA AQVIAIDVSD DKLAPMPGYG ATAVVNSVTH DAREEVLRLT GGTGVDVAFE
ALGIPATWKT ALDVLADGGR MVPIGLGAGV QTAEVEINRT VRRSQSILGS YGARTRQDLP
AVVDLAARGV INYKDVVSRR FPLSEAGAGY EALRNHRIQG RAVVDMSL
//
