ID   F9FNS3_FUSOF            Unreviewed;      1012 AA.
AC   F9FNS3;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=Pro-apoptotic serine protease NMA111 {ECO:0000256|ARBA:ARBA00020338};
DE   AltName: Full=Pro-apoptotic serine protease nma111 {ECO:0000256|ARBA:ARBA00021524};
GN   ORFNames=FOXB_08053 {ECO:0000313|EMBL:EGU81471.1};
OS   Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium oxysporum species complex.
OX   NCBI_TaxID=660025 {ECO:0000313|EMBL:EGU81471.1};
RN   [1] {ECO:0000313|EMBL:EGU81471.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fo5176 {ECO:0000313|EMBL:EGU81471.1};
RX   PubMed=21942452; DOI=10.1094/mpmi-08-11-0212;
RA   Thatcher L.F., Gardiner D.M., Kazan K., Manners J.;
RT   "A highly conserved effector in Fusarium oxysporum is required for full
RT   virulence on Arabidopsis.";
RL   Mol. Plant Microbe Interact. 25:180-190(2012).
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000256|ARBA:ARBA00002558}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family.
CC       {ECO:0000256|ARBA:ARBA00010541}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGU81471.1}.
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DR   EMBL; AFQF01002433; EGU81471.1; -; Genomic_DNA.
DR   AlphaFoldDB; F9FNS3; -.
DR   STRING; 660025.F9FNS3; -.
DR   PaxDb; 5507-FOXG_08589P0; -.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd00987; PDZ_serine_protease; 1.
DR   Gene3D; 2.30.42.10; -; 2.
DR   Gene3D; 2.40.10.120; -; 1.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   PANTHER; PTHR46366; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR   PANTHER; PTHR46366:SF8; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR   Pfam; PF12812; PDZ_1; 2.
DR   Pfam; PF13365; Trypsin_2; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SUPFAM; SSF50156; PDZ domain-like; 2.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022825};
KW   Protease {ECO:0000256|ARBA:ARBA00022825};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT   DOMAIN          390..466
FT                   /note="PDZ-like"
FT                   /evidence="ECO:0000259|Pfam:PF12812"
FT   DOMAIN          865..942
FT                   /note="PDZ-like"
FT                   /evidence="ECO:0000259|Pfam:PF12812"
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1012 AA;  112186 MW;  AFB5E4B74B13D55A CRC64;
     MNGANSSARA KRKAPGSPGE APPSKKPING KHSPNDNTPD IIEFDDNSDM TDELHPHAMY
     IGTPGSLGEW QDTIQKVVRN VVAIRFCQTC SFDTDSALTS EATGYVVDSE KGYILTNRHV
     VGAGPFWGHC VFDNHEEVDC YPVYRDPVHD FGILRYDPKA IKYMHIDGLE LRPDLAKVGT
     EIRVVGNDAG EKLSILSGII SRLDRNAPEY GEGYSDFNTC YYQANAAASG GSSGSPVVNK
     DGCAVALQAG GRSDGASTDY FLPLDRPLRA LQCIQNGKPV TRGDIQCQFL LKPFDECRRL
     GLSPHWEAAM REKFPEETNM LVAEIVLPQG PSDKKIEEGD VLIKVNGELI TQFIRLDDIL
     DSSVGETIKL HLQRGGQDVE VEIEVGDLHK ITPDRFVSVA GASFHDLSYQ QARLYAVAVK
     GVYVCESAGS FRFDNTDNGW IVQSIDHKKV PDLDTFIQVM KAIPDRARVV VTYKHLRDLH
     TLNTTVAYID RHWAAKMKLA VRNDETGVWD FTDLGDPLPP VPPTRRSASF IELDHMPHQG
     IADLIRSFVH INCTMPLKLD GFPKNRRWGM GLVIDADKGL VLISRAIVPY DLCDITVTIA
     DSIIVEGKVV FLHPLQNYAI IQYDPSLVDA PVMSARLSNE VLTQGAKTYF LGYNRIGRVV
     HGSTSVTEIT AVAIPANSGA PRYRAVNVDA ITIDSNLGST CNSGVLVAPD GTVQALWLSY
     LGERSHHTSR DEEYYLGLGT KTLLPVVESV QKGINPKLRI LSVEFRSVQM AQASVMGVSD
     EWIKKVTQTN RSHHQLFMVS KRTFERENHP VSLLEGDIIL TLNGKICTTI SDFDLMYSHE
     LLDAVIVREC EEMHLQLPTV AADDMETNHA VSFCGAILHR PHQAVRQQIS KLHSEVYVSS
     RIRGSPAYQY GVAPTNFITH VNGTPTPDLD SFIAATREIP DNTYFRLKAV TFDCVPWVIT
     MKKNDHYFPT MEWIKDDKEA CGWRRVTYEG SEVFKGEATD GVVPVAQDAD ME
//