ID F9FYM4_FUSOF Unreviewed; 1609 AA.
AC F9FYM4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Glycerol-3-phosphate dehydrogenase {ECO:0000256|ARBA:ARBA00013029, ECO:0000256|RuleBase:RU361217};
DE EC=1.1.5.3 {ECO:0000256|ARBA:ARBA00013029, ECO:0000256|RuleBase:RU361217};
GN ORFNames=FOXB_11506 {ECO:0000313|EMBL:EGU77988.1};
OS Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=660025 {ECO:0000313|EMBL:EGU77988.1};
RN [1] {ECO:0000313|EMBL:EGU77988.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fo5176 {ECO:0000313|EMBL:EGU77988.1};
RX PubMed=21942452; DOI=10.1094/mpmi-08-11-0212;
RA Thatcher L.F., Gardiner D.M., Kazan K., Manners J.;
RT "A highly conserved effector in Fusarium oxysporum is required for full
RT virulence on Arabidopsis.";
RL Mol. Plant Microbe Interact. 25:180-190(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinone + sn-glycerol 3-phosphate = a quinol +
CC dihydroxyacetone phosphate; Xref=Rhea:RHEA:18977, ChEBI:CHEBI:24646,
CC ChEBI:CHEBI:57597, ChEBI:CHEBI:57642, ChEBI:CHEBI:132124; EC=1.1.5.3;
CC Evidence={ECO:0000256|RuleBase:RU361217};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU361217};
CC -!- SIMILARITY: Belongs to the FAD-dependent glycerol-3-phosphate
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00007330,
CC ECO:0000256|RuleBase:RU361217}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGU77988.1}.
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DR EMBL; AFQF01002890; EGU77988.1; -; Genomic_DNA.
DR STRING; 660025.F9FYM4; -.
DR PaxDb; 5507-FOXG_13941P0; -.
DR GO; GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:UniProtKB-UniRule.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004368; F:glycerol-3-phosphate dehydrogenase (quinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.8.870; Alpha-glycerophosphate oxidase, cap domain; 1.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR031656; DAO_C.
DR InterPro; IPR038299; DAO_C_sf.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000447; G3P_DH_FAD-dep.
DR InterPro; IPR005330; MHYT_dom.
DR PANTHER; PTHR11985; GLYCEROL-3-PHOSPHATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11985:SF15; GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16901; DAO_C; 1.
DR Pfam; PF03707; MHYT; 2.
DR PRINTS; PR01001; FADG3PDH.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00977; FAD_G3PDH_1; 1.
DR PROSITE; PS00978; FAD_G3PDH_2; 1.
DR PROSITE; PS50924; MHYT; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU361217}; Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU361217}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..218
FT /note="MHYT"
FT /evidence="ECO:0000259|PROSITE:PS50924"
FT REGION 409..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 696..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1609 AA; 178152 MW; EC9F7EC34A03F902 CRC64;
MSTEELLQRY QGHIVPQSYN AGFVALSYVV SLVGAGSTLE LINRRTGLRG LFNHLLLMSS
AVTMGGVSIW CMHFIGNRAI DLADGQPELQ VAYSSGFTAI SFFVPIIVLL AAFMAVGTNN
VVSWWRLVAG GVLCGTAVCG MHYLGNASIN NYTCVYQPSY VIGSAIIAIV ASNVALAMFF
VFRAMWANAW WKRVISAVVL AGAVSGMHWC ASVGTRYRLK RIKPNGNEPS RTGTVVVVIC
LSLGACFIIA TSAILRARNM RRSALRAQQI TLAAAVFDKG GRILVDPDGY IPSTVVTDSF
LEKQNAKEGF NTGHSLFHWM YQASRNWNMI WSLVGGMRQH VSQLPHSRTH KDGRRGIQLV
SEHGETIDSY DMIFRELFCL AAAALADRLR EDLTSIGVLW DQILPTGANG RRPRPQLRKQ
SNAGTGLEGS DANEEVHNSL DITEKGLHVE NHDYGRGSLM FLVRRSESVR DTERLISTGY
RFAELHQVSD LIKSSMQIKT HDFETKLREM ATYTSERNHI RQGTHLGFFA VRARVSSGFE
VLVRKGARHL LPSMPFPFEN LEDWQMHYLR RFENVPVSKI VEKCKEDSQR SDREAEFAGQ
IADTIKELRE STQEPLLEDA LLTSTAFRIP CRGDEKRLEA TMIAVRLVIP IHSVLSSPNC
EFVPLSFFRM RQVSTQAYQE FTRGLHQEFG HIAKTAKRQE GSQDKISPSL SSRWPFGRSE
TTRSTRTRGK SLSRISGHVV SSNDSARSSS TINLCSPGTN ARTQSIDSGE GSSTYVPRQE
PLQATPSYGG IMVFQEITVD VQEGGETAAR KPSHGSEVDT ITIERTISKP SAAAGIELQS
MGHFGANDIG TQLSNDIEAG ICICLYLTLH ICPSWFQSKY HTPSSSRYRT KSLNKLPLKV
VLLPQMPAFA GAPRGLIRRF WLPGVVTTSA AVLIYSYRPR DFTGHTSPAV PPPTFGADGT
FKLPRFPRVK TREEQLDQLR GSSRPQVQQY DILVIGGGAT GAGVALDAAT RGLKVAVVER
DDFSSGTSSK STKLVHGGVR YLEKAVWNLD YNQYLLVKEA LKERKYFLQT APHLSSWLPI
MLPLDKWWKA PYYWAGTKFY DFLAGSEGIE GSYFLTRSKA LEAFPMLKPT DLVGALVYYD
GAHNDSRMNV SIAMTAALYG ATVVNHAEVT GLIKNGDGNL CGAIVRDLVS VKDGRPAEVI
TVRAKSVINC TGPFTDSVRK MDDPGCKEIV APASGVHVIL PGYFSPGKMG LIDPSTSDGR
VIFFLPWQGN TIAGTTDSPS TITPNPLPDE KSIEWILSEI SHYLSPEINV RRGDVLAAWS
GIRPLVKDPK AKNTESLVRN HLIDISASGL LTCAGGKWTT YRQMAEECVD FAIQEFRLEP
RPVADAPRVS GTDLIDDGAI LDGKCQTHKV RLLGAHGFSP TLFIPIIQHF GVETEVAKHL
TESYGDRAWT VASLCKLTDK RFPARGERIS QLYPFVDGEI RYAIRHEYAQ TAVDVLARRT
RLAFLNAQAA LEALPKVIDI MAEELKWSRQ RKDLEWKECA YYGQFPIPSV SAMTRLPHSH
KPLAVAYLES MGLPKPMLTV TRKQVEQGKL DFASSLEWQM YSRHDKPTD
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