ID F9HN61_STRMT Unreviewed; 750 AA.
AC F9HN61;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Penicillin-binding protein 2X {ECO:0000313|EMBL:EGP68331.1};
GN Name=pbpX {ECO:0000313|EMBL:EGP68331.1};
GN ORFNames=HMPREF9957_1310 {ECO:0000313|EMBL:EGP68331.1};
OS Streptococcus mitis SK1080.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1008453 {ECO:0000313|EMBL:EGP68331.1, ECO:0000313|Proteomes:UP000004568};
RN [1] {ECO:0000313|EMBL:EGP68331.1, ECO:0000313|Proteomes:UP000004568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK1080 {ECO:0000313|EMBL:EGP68331.1,
RC ECO:0000313|Proteomes:UP000004568};
RA Durkin A.S., Radune D., Hostetler J., Torralba M., Gillis M., Methe B.,
RA Sutton G., Nelson K.E.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGP68331.1}.
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DR EMBL; AFQV01000021; EGP68331.1; -; Genomic_DNA.
DR RefSeq; WP_000872307.1; NZ_AFQV01000021.1.
DR AlphaFoldDB; F9HN61; -.
DR PATRIC; fig|1008453.3.peg.1131; -.
DR eggNOG; COG0768; Bacteria.
DR OrthoDB; 9804124at2; -.
DR Proteomes; UP000004568; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR CDD; cd06573; PASTA; 2.
DR Gene3D; 2.20.70.70; -; 2.
DR Gene3D; 3.30.70.2110; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; NF038271; strep_PBP2X; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03793; PASTA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SMART; SM00740; PASTA; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR SUPFAM; SSF54184; Penicillin-binding protein 2x (pbp-2x), c-terminal domain; 2.
DR PROSITE; PS51178; PASTA; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 632..691
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT DOMAIN 692..750
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
SQ SEQUENCE 750 AA; 82501 MW; C093E5B6CC70899A CRC64;
MKWTKRVIRY ATKNRKSPAE NRRRVGKSLS LLSVFVFAVF LVNFAVIIGT GTRFGTDLAK
EAKKVHQTTR TVPAKRGTIY DRNGVPIAED ATSYNVYAVI DENYKSATGK ILYVEKTQFN
KVAEVFHKYL DMEESYVREQ LSQPNLKQVS FGSKGNGITY ANMMAIKKEL ETAEVKGIDF
TTSPNRSYPN GQFASSFIGL AQLHENEDGS KSLLGTSGME SSLNRILAGT DGIITYEKDR
LGNIVPGTEQ VSQQTVDGKD VYTTISSTLQ SFMETQMNAF QEKVKGKYMT ATLVSAKTGE
ILATTQRPTF DADTKEGLTK DFVWRDILYQ SNYEPGSTMK VMTLASSIDN NTFPSGEYFN
SSELKIADVT IRDWDVNDGL TTGRMMTFLQ GFALSSNVGM SLLEQKMGDT TWLDYLNRFK
FGVPTRFGLT DEYAGQLPAD NIVNIAQSSF GQGISVTQTQ MIRAFTAIAN DGVMLEPKFI
SAIYDPNDQT ARKSQKEVVG NPVSKDAASL TRTNMILVGT DPVYGTMYNH STGKPTVTVP
GQNVALKSGT AQIADEKNGG YLVGLTNYIF SAVSMNPAEN PDFILYVTVQ QPEHYSGIQL
GEFANPILER ASAMKDSLNL QTTAKALEQV SQQSPYPMPS VKDISPGDLA EELRRNLVQP
IVVGTGTKIK NSSAEEGKNL APNQQVLILS DKAEEVPDMY GWTRATAETF AKWLNIDLEF
EGSGSTVQKQ DVRANTAIKG IKKITLTLGD
//
