ID F9W2X3_MONDO Unreviewed; 1794 AA.
AC F9W2X3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|EMBL:DAA34922.1};
RN [1] {ECO:0000313|EMBL:DAA34922.1}
RP NUCLEOTIDE SEQUENCE.
RA Zakon H., Lu Y.;
RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:DAA34922.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21148285; DOI=10.1093/molbev/msq325;
RA Zakon H.H., Jost M.C., Lu Y.;
RT "Expansion of voltage-dependent Na+ channel gene family in early tetrapods
RT coincided with the emergence of terrestriality and increased brain
RT complexity.";
RL Mol. Biol. Evol. 28:1415-1424(2011).
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; BK007945; DAA34922.1; -; mRNA.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF210; SODIUM CHANNEL PROTEIN TYPE 11 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132, ECO:0000313|EMBL:DAA34922.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 118..140
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 160..182
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 194..211
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 231..249
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 367..388
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 574..592
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 604..627
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 639..658
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 696..719
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 775..801
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1180..1199
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1249..1269
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1289..1312
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1362..1387
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1407..1426
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1438..1456
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1493..1521
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1541..1568
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1589..1615
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 126..405
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 574..810
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 818..1046
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1050..1321
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1370..1625
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
SQ SEQUENCE 1794 AA; 204885 MW; 3A98B8BB334A9833 CRC64;
MACPVIFPDA RNFHLFTPDS LAMIEKLIQA EKSKKKTPNP AVLEAPLRPQ LDLKVSRKLP
KIYGDIPPEV VGQPLEDLDP FYFNHKTFMV LNKKRTIYRF SAKSALFVLG PFNPIRRLAI
IVSFTLFSMF IICTVIVNCV IQWWEHSTTI KARPSSSLPL FKYVFTAIYV FEALIKILAR
GLVLDEFTYL RDPWNWLDST VIMLAFLSCK IEKLDSVSAL RTFRVLRALK AISIISGLKV
IVGALLRSVK KLVDVMILTI FCLSIFALVA QQLFMGSLRY RCIRKTCLNH EYERCSEKKS
EGSSEARLCG TWMGNRSCCP DFVCCKTKLS PDYGFTNFDH FGWAFLSMFR VMTQDSWERL
YQQTLRVAGP FAVVFFVVII FLGSFYLINL TLAVVTMSYE EQNKNVAAET EAKEKMFKEA
LQLLKQEQET LVAMGIDRSS LNSLETSSIS CQKRSLFGNK RRKSFLVANS GQVPGPPSDS
DESVQTKQQI LSQTKRLSQN LSLDYWDEHG DTFQRQRALS AVSIVTITMQ EYEKSQQKCL
PCQNNFASKY LIWESSPRWL RIKRVVELVI MDPFADLAIT ICIILNTIFM SMEHYGQGKD
FDKMLCIGNY VFTGIFIAEM CLKIIALDPY YYFLRPWNIF DSIIVILSIV EIIISDVLKS
NLSILRSLRL LRVFKLAKSW PTLNTLIKII GHSVGALGNL TLVLAIIVFI FSVVGVQLFG
NSFNGTLPQN GSSQVPKCRR WHMGDFFHSF LVVFRILCGE WIDNMWECMQ NSSHVLCILV
FLLILVIGNL VVLNLFIALL LNSFSSEEKE GNGPGEMRKT KLQLAFDRFR RAFYYVKHAI
GHFCSRSFRK QRSRKLKDVS KKCKVQDKDI IPLESGINQE QRNQEKICSQ DQDSSFGFTG
LGSLQENLNT RYAPFIKAPL AEEEEDQEFM VEDELQNFME TEFYKQAEKE CASPGATSGD
IDVFFEDGPE LAAPKLRESF DVTSYLSDCS TIDLKDLVLL VPEMLPPKGP ERCLPKGCNK
CFPCFALNVR KSPGIIWLRL RITCYRIVKH DWFESFIIFM ILLSSGALIF EDCSLQSKPK
IKELLNFTDR VFTYIFTLEM FLKWVAFGFR KYFTNAWCCL DFLIVNVSLT STFSCSPKSF
NVKSFRTLRA LRPLRALSQF EGMKVVVNAL IGAIPAIMNV LLVCLIFWLI FCMLGVNLFS
GKFRKCINQT KNDELVNHTT ISNMSMCNST ENPHVCWINT KVNFDHVGIG YLALLQVATF
KGWMEIMYAA VDSRKVSEQP YFEANLYAYL YFVVFIIFGS FFTLNLFIGV IIDNFNQQQK
KLGGQDIFMT EEQKKYYNAM KKLGSKKPQK PIPRPLNKCQ AFVFDVVTNQ AFDIFIITLI
CLNMVTMMAE TDSPEGPNKQ KENLLEYLNR AFVVIFTVEC LLKIFALRQF YFANGWNLFD
CVVVVLSIVS NMVALLEKNK AIPFPPVLFR VIRLARIGRI LRLVRAAKGI RTLLFALMMS
LPSLFNIGLL LFLVMFIYAI IGMTNFAHVK YDAGIDDMFN FQTFGSSMLC LFQITTSAGW
DALLSPMLSS KSASCRSDDS PCIPGSSSVM AIAFFVSYII ISFLIVVNMY IAVILENFNT
ATEESEDPLS EDDFDIFYET WEKFDPEATQ FIEYSVLSDF ADALPDPLRV PKPNRNQLLM
MDLPMVSGNR LHCMDILFAF TTRVLGDSEG IDCLKSQMEE KFMEANPNKK LYEPIMTTTK
RVEEERCAAV IQKAYRHYLK KNSARKAVTS SPHQMVCNGA IDTLEVPDGK VHFD
//
