ID F9W2X5_ORNAN Unreviewed; 1551 AA.
AC F9W2X5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Voltage-dependent sodium channel SCN10A {ECO:0000313|EMBL:DAA34924.1};
DE Flags: Fragment;
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|EMBL:DAA34924.1};
RN [1] {ECO:0000313|EMBL:DAA34924.1}
RP NUCLEOTIDE SEQUENCE.
RA Zakon H., Lu Y.;
RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:DAA34924.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21148285; DOI=10.1093/molbev/msq325;
RA Zakon H.H., Jost M.C., Lu Y.;
RT "Expansion of voltage-dependent Na+ channel gene family in early tetrapods
RT coincided with the emergence of terrestriality and increased brain
RT complexity.";
RL Mol. Biol. Evol. 28:1415-1424(2011).
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DR EMBL; BK007947; DAA34924.1; -; mRNA.
DR SMR; F9W2X5; -.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 3.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF208; SODIUM CHANNEL PROTEIN TYPE 10 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000313|EMBL:DAA34924.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 100..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 653..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 682..703
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..732
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 772..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 858..883
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1151..1174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1186..1206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1218..1237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1282..1302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1354..1374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1394..1417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1507..1525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 128..416
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 503..569
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 653..888
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 897..1144
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1149..1426
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1476..1551
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 456..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 937..974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1005..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 418..445
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 473..490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1551
FT /evidence="ECO:0000313|EMBL:DAA34924.1"
SQ SEQUENCE 1551 AA; 174996 MW; 015B2473BC8E2CAD CRC64;
MADPLDFLEV GNFRPLTCES LAAIEARAAE RKSARAQKGT EAPGPKEEKL RPQRVLKACN
QLPKFYGELP TELVGVPLED MDPFYSTRKT FMVLNKGRTI FRFSATNALF VLSPFHPIRR
VAVKISVHKY FSLFIMATIL ANCVFMTQAD PPPSAEYVWY TFTGIYTFES LIKILARGFC
LNEFTYMWDM WNILDFCIII LAYLAEFVDL KGVSALRTFR VFRALKTVSV IPGLKVIVGA
LIHSVKKLAD VMVLTVFCLS VFALVGLQLF KGNLKNICVK NCSALNLTEE GLPINRTWDF
CSKDTDYRAF KNGTQDHLLC GNGSDAGQCP HGYWCQKIGP NPDYGYTSFD SFGWAFLSLF
RLMTQDYWER LYQQTLRASG KVYMIFFVLV IFLGSFYLVN LILAVVTMAY EEQNQATIAE
TEEKERKFRE ALEVLKKEHE ALEALGIDTA SLTSLETSPH ASRLTKERKS WRRPRGKLLE
ADDHQDGARA SESEALPGQR RMSVLGLSHG PGGSPAKRRT SHGSVFTFRP RGRDGWATEA
SEDDGSFSGE NESRQEALRL AQMDRHLSVQ DLVRKNRLSV QTLSPDYLDE PLRLQRAMSV
VSVITSVLEE LEESEQRCPP CLSRVASKYL VWDCGPRWRR FKLMVRAVVT DPLVELAVTA
CIVLNTLFMA MHYKMTETFK LLLHIGNLVF TGIFTAEMVF KVIALDPYYY FQTSWNIFDS
IIVILSLMEL GLPKKGSLSV LRSFRLLRVF KLAKSWPTLN TLIKIIGNSV GALGNLTLVL
AIIVFIFAVV GMQLFGNSFN CTKKNETFAP PITQSNRENF RRWHMGDFFH SFLIVFRILC
GEWIENMWEC MEVAHKPLCL FIFLLVMVIG NLVVLNLFIA LLLNSFSADN LLAPEEDSEL
NNLQVALARL RAAAWRGRRI VLDALMGFCK LPSLGAEKPA PPSPGAPNHL GPESLEFRKA
GKTGGETAPN GAVRQWGPCW EVDGLLSGPG LVVTVPIAEA ESDIEDGEDE GDSQDRHSAN
SPPASPRLDA EPEERVAPPE GHCTPNLRSP TPSQDLALDV DKEWTAKVSQ PYSTEKLDDT
SCSEGSTVVV PDADEIVKQI TELADVLEEP EDCCTECRSR FPCCVGDPSS RAGLLWWRLR
KTCFLMVEHS WFESFIIFMI LLSSGTLAFE DIYLEGRQTV KAILDYADLL FTYIFILEML
LKWVAYGFQK YFTNAWCWLD FLIVDVSLIS LVANALGHSD LGPIKSLRTL RALRPLRALS
RFEGMRVVVD ALVGAIPSIM NVLLVCLIFW LIFSIMGVNL FAGKFGRCVN QTGDNWETPL
DSSLINNKSE CEGLNVTGDL KWIQVRVNFD NVGLGYLALL QVATFKGWMD IMYAAVDSRK
EEEQPIWEFN LYMYLYFVIF IIFGGFFTLN LFVGVIIDNF NQQKKKDLGG QDIFMTEEQK
KYYNAMKKLG SKKPQKPIPR PLNKYQGFLF DIVTKQAFDV TIMVLICLNM VTMMVETDDQ
SEGKTNILAK INLLFVAIFT AECVVKMVAL RHYFFTNGWN VFDLIVVVLS I
//
