ID F9XJX4_ZYMTI Unreviewed; 1239 AA.
AC F9XJX4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=tRNA wybutosine-synthesizing protein 4 {ECO:0000256|ARBA:ARBA00018045};
DE EC=2.1.1.290 {ECO:0000256|ARBA:ARBA00012779};
DE EC=2.3.1.231 {ECO:0000256|ARBA:ARBA00012155};
DE AltName: Full=Leucine carboxyl methyltransferase 2 {ECO:0000256|ARBA:ARBA00030231};
DE AltName: Full=tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase {ECO:0000256|ARBA:ARBA00030847};
DE AltName: Full=tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase {ECO:0000256|ARBA:ARBA00029750};
GN ORFNames=MYCGRDRAFT_110727 {ECO:0000313|EMBL:EGP84720.1};
OS Zymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch
OS fungus) (Septoria tritici).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Zymoseptoria.
OX NCBI_TaxID=336722 {ECO:0000313|EMBL:EGP84720.1, ECO:0000313|Proteomes:UP000008062};
RN [1] {ECO:0000313|EMBL:EGP84720.1, ECO:0000313|Proteomes:UP000008062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 115943 / IPO323 {ECO:0000313|Proteomes:UP000008062};
RX PubMed=21695235; DOI=10.1371/journal.pgen.1002070;
RA Goodwin S.B., Ben M'barek S., Dhillon B., Wittenberg A.H.J., Crane C.F.,
RA Hane J.K., Foster A.J., Van der Lee T.A.J., Grimwood J., Aerts A.,
RA Antoniw J., Bailey A., Bluhm B., Bowler J., Bristow J., van der Burgt A.,
RA Canto-Canche B., Churchill A.C.L., Conde-Ferraez L., Cools H.J.,
RA Coutinho P.M., Csukai M., Dehal P., De Wit P., Donzelli B.,
RA van de Geest H.C., van Ham R.C.H.J., Hammond-Kosack K.E., Henrissat B.,
RA Kilian A., Kobayashi A.K., Koopmann E., Kourmpetis Y., Kuzniar A.,
RA Lindquist E., Lombard V., Maliepaard C., Martins N., Mehrabi R.,
RA Nap J.P.H., Ponomarenko A., Rudd J.J., Salamov A., Schmutz J.,
RA Schouten H.J., Shapiro H., Stergiopoulos I., Torriani S.F.F., Tu H.,
RA de Vries R.P., Waalwijk C., Ware S.B., Wiebenga A., Zwiers L.-H.,
RA Oliver R.P., Grigoriev I.V., Kema G.H.J.;
RT "Finished genome of the fungal wheat pathogen Mycosphaerella graminicola
RT reveals dispensome structure, chromosome plasticity, and stealth
RT pathogenesis.";
RL PLoS Genet. 7:E1002070-E1002070(2011).
CC -!- FUNCTION: Probable S-adenosyl-L-methionine-dependent methyltransferase
CC that acts as a component of the wybutosine biosynthesis pathway.
CC Wybutosine is a hyper modified guanosine with a tricyclic base found at
CC the 3'-position adjacent to the anticodon of eukaryotic phenylalanine
CC tRNA. May methylate the carboxyl group of leucine residues to form
CC alpha-leucine ester residues. {ECO:0000256|ARBA:ARBA00025588}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in
CC tRNA(Phe) + CO2 + S-adenosyl-L-methionine = 2 H(+) + S-adenosyl-L-
CC homocysteine + wybutosine(37) in tRNA(Phe); Xref=Rhea:RHEA:37119,
CC Rhea:RHEA-COMP:11844, Rhea:RHEA-COMP:11847, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:73544, ChEBI:CHEBI:74275; EC=2.3.1.231;
CC Evidence={ECO:0000256|ARBA:ARBA00000401};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-
CC adenosyl-L-methionine = 7-[(3S)-(3-amino-3-
CC methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:36903, Rhea:RHEA-COMP:10379, Rhea:RHEA-
CC COMP:11844, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:73543,
CC ChEBI:CHEBI:74275; EC=2.1.1.290;
CC Evidence={ECO:0000256|ARBA:ARBA00001806};
CC -!- PATHWAY: tRNA modification; wybutosine-tRNA(Phe) biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004797}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. LCMT family.
CC {ECO:0000256|ARBA:ARBA00010703}.
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DR EMBL; CM001204; EGP84720.1; -; Genomic_DNA.
DR RefSeq; XP_003849744.1; XM_003849696.1.
DR AlphaFoldDB; F9XJX4; -.
DR STRING; 336722.F9XJX4; -.
DR EnsemblFungi; Mycgr3T110727; Mycgr3P110727; Mycgr3G110727.
DR GeneID; 13399066; -.
DR KEGG; ztr:MYCGRDRAFT_110727; -.
DR eggNOG; KOG2132; Eukaryota.
DR eggNOG; KOG2918; Eukaryota.
DR HOGENOM; CLU_002761_1_0_1; -.
DR InParanoid; F9XJX4; -.
DR OMA; WEVDFPD; -.
DR OrthoDB; 9938at2759; -.
DR UniPathway; UPA00375; -.
DR Proteomes; UP000008062; Chromosome 9.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 6.10.140.1470; -; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR041667; Cupin_8.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR46529; TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4; 1.
DR PANTHER; PTHR46529:SF1; TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4; 1.
DR Pfam; PF13621; Cupin_8; 1.
DR Pfam; PF13854; Kelch_5; 1.
DR SMART; SM00558; JmjC; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF50965; Galactose oxidase, central domain; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51184; JMJC; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000008062};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 977..1143
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT REGION 74..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 854..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1239 AA; 135512 MW; 33C2FDC23789C7C9 CRC64;
MEFMEAHLQL EEKSFSPAAR YQGSLQYLIL AFTQQPSQYL NVITSSCWSI VYSGRSNLIS
VLLAQYNYRE GSPVMGANDR NDTSPQTESS YAGNKHDNAI NPEKALRLLG IRTDSPSSMA
ADTEADDMDA AHLDNRSAGK MLQAEKFLGT AVQVKRSSSV PMMNGKQTSK PVIDPAKQHR
DELIMDTNKS SIVSKRSVEK LYYAGQPEYF RYFVNKFKRR SPLINRGYWL RMKAIDDPLP
WLFLGKQPQL CQNTVFVDVD YPELMQQKLS VIDKTEQLKE LLPKFTRTGK ESGLLASSDP
YVAIGCDLIN LSPLQEILQD HLQAGSGSVA ILFTSEVSTA YMEREASQAV FQWAATFDDV
RFCLLEQHLP DGPDHPFAAT MLAHFDKLRT PLRAAGTMEE MKARFVSAGF PESGTDIRSL
WELWSDPTFL SAEERRALDR VEPFDEWEEF ALFGSHYFLL VAEKEPNKNY SQTSVHRASR
ASFFAGSSRA SMVSSPSSDR PDVPQYHFTA SDVVDAHEIL EPHDYRRFTA IIPPAFAESS
DGSVGLHGGM GTQERLSSCN TYSSFEAGHA LEPIIGPPIR NGIMCHAVTK LGSTSNCVLT
GGRTSPDKAS AESWLRLDGK WRRVQDLPTG RFRHCAVPLV LPTNPRPAHT VLMFGGKTGD
GQVLDEWLIW TGETGWQQVT MKGEEKPAAR FGATMITDSR EGTSGVLIGG MTSAGRVLND
FWHWNLERDM TLTCRNVTTR ATAFLKADAC ILGRFGAQLV RSPQGILMIG GITGARMLTR
QDEILNMKTL RPQPLEGSRP LFVGHSVQDV DDSILILGGG ATCFSFGTSW SRSCLLNRTP
PDSFQMIWQL QTTQEAGKPT AEQSKPFNET PKNPNPSTQS LALPIPTPIP EQTLTSTTSF
PTIISASRPI IFKSCDLGRC TSLWTTPYLK SAVGATRPVS IHSPTTPSTS TLSFASKNFT
YTTLPFGDFL DAIDAGQHLY LRSLSSTSPS TLPTHLATDF PALAPDFTLP PQLSLAMDSA
HSSPLRISGP VNIWLHFDIH ANLLCQIRGT KRLLLFPPSD VSHLGFPPSA SSSPIDVFAS
DPPSTLAQTT PYEAILHPGD VLFVPPMWPH TAQPLTDTSV AVNVFFRNLM EKGYAAGKDV
YGNRDLAAYE KGRKDLAKII RAFDGLPAEV AGFYLERLGT ELVEKGQGLM RSSAIGGGGG
AAVGGASISG PLSDGGNGSA GQNGGGGGEN LHRTYAELG
//