UniProt: F9XL93

Database: UniProt
Entry: F9XL93_ZYMTI

LinkDB:  F9XL93_ZYMTI 
Original site:  F9XL93_ZYMTI

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Ontology (2)   
   GO (2)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (19)   
   InterPro (9)   
   Pfam (3)   
   PROSITE (4)   
   SMART (3)   
Literature (1)   
   PubMed (1)   
All databases (26)   

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ID   F9XL93_ZYMTI            Unreviewed;      1144 AA.
AC   F9XL93;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   SubName: Full=Guanine-nucleotide dissociation stimulator CDC25 {ECO:0000313|EMBL:EGP83764.1};
GN   ORFNames=MYCGRDRAFT_101362 {ECO:0000313|EMBL:EGP83764.1};
OS   Zymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch
OS   fungus) (Septoria tritici).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Zymoseptoria.
OX   NCBI_TaxID=336722 {ECO:0000313|EMBL:EGP83764.1, ECO:0000313|Proteomes:UP000008062};
RN   [1] {ECO:0000313|EMBL:EGP83764.1, ECO:0000313|Proteomes:UP000008062}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 115943 / IPO323 {ECO:0000313|Proteomes:UP000008062};
RX   PubMed=21695235; DOI=10.1371/journal.pgen.1002070;
RA   Goodwin S.B., Ben M'barek S., Dhillon B., Wittenberg A.H.J., Crane C.F.,
RA   Hane J.K., Foster A.J., Van der Lee T.A.J., Grimwood J., Aerts A.,
RA   Antoniw J., Bailey A., Bluhm B., Bowler J., Bristow J., van der Burgt A.,
RA   Canto-Canche B., Churchill A.C.L., Conde-Ferraez L., Cools H.J.,
RA   Coutinho P.M., Csukai M., Dehal P., De Wit P., Donzelli B.,
RA   van de Geest H.C., van Ham R.C.H.J., Hammond-Kosack K.E., Henrissat B.,
RA   Kilian A., Kobayashi A.K., Koopmann E., Kourmpetis Y., Kuzniar A.,
RA   Lindquist E., Lombard V., Maliepaard C., Martins N., Mehrabi R.,
RA   Nap J.P.H., Ponomarenko A., Rudd J.J., Salamov A., Schmutz J.,
RA   Schouten H.J., Shapiro H., Stergiopoulos I., Torriani S.F.F., Tu H.,
RA   de Vries R.P., Waalwijk C., Ware S.B., Wiebenga A., Zwiers L.-H.,
RA   Oliver R.P., Grigoriev I.V., Kema G.H.J.;
RT   "Finished genome of the fungal wheat pathogen Mycosphaerella graminicola
RT   reveals dispensome structure, chromosome plasticity, and stealth
RT   pathogenesis.";
RL   PLoS Genet. 7:E1002070-E1002070(2011).
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DR   EMBL; CM001205; EGP83764.1; -; Genomic_DNA.
DR   RefSeq; XP_003848788.1; XM_003848740.1.
DR   AlphaFoldDB; F9XL93; -.
DR   STRING; 336722.F9XL93; -.
DR   EnsemblFungi; Mycgr3T101362; Mycgr3P101362; Mycgr3G101362.
DR   GeneID; 13398749; -.
DR   KEGG; ztr:MYCGRDRAFT_101362; -.
DR   VEuPathDB; FungiDB:ZTRI_10.112; -.
DR   eggNOG; KOG1118; Eukaryota.
DR   eggNOG; KOG3417; Eukaryota.
DR   HOGENOM; CLU_002632_0_0_1; -.
DR   InParanoid; F9XL93; -.
DR   OMA; WMEDQSD; -.
DR   OrthoDB; 68574at2759; -.
DR   Proteomes; UP000008062; Chromosome 10.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   CDD; cd11883; SH3_Sdc25; 1.
DR   CDD; cd00201; WW; 1.
DR   Gene3D; 2.20.70.10; -; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR001202; WW_dom.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008062};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          9..68
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          721..854
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          890..1127
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          69..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          145..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          186..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..112
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..160
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..243
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1144 AA;  127828 MW;  21FFA36611CC3DAD CRC64;
     MNGLAGQPAG QMYVRALYDY EADDQTSLSF RQGDIIQVIT QLESGWWDGV IHGTRGWFPS
     NYCAVVSHPS DSNAYGRNGR AGDSEAEESE EEFGEHDNTT PATSNGHRDG AATSTQEEAA
     FWIPQATPDG RLFYFNTLTG ESTMELPLEA PTSANETGPR DRTNIYIPEQ TRPPAEFLAA
     GYERDEDTDY ASASEAEDAS VAQGSKSSST HRRRRSFLSD GVSPATSMDS LSAPSPMSRS
     RTNLTDANNL SLSAMQQGLP PNGTTATSFA HAPAGGSSLS LLPRRFFDDA HAVPLTWNTM
     VEDMRRAVQR YREVINRGDR SEYVRKAEDI SDHLRLLLAA GSGTTDNHSG NPSIISTNKA
     LYPHFREMMS RFSKLVLSSH IAAADWPAPD SNQKCLQEAE GVLHGVYGFV EVARQQRGEE
     IPRLVPGFIS GSKTAGSWQN NGLNPRNNLA SMSFMDEEAD TSAEPNATLD AALLERLDDL
     KRLIVSSIRR LDEHLVLREK LITPQKHRHI SDKICSSGKQ VIEVCRPYLS TVESINFAPL
     TNTFQTPQLN DFSEHKQKLY DSTSDLIFAC QSVAAPLADE WAETRGPTLE ERVTRVKSVS
     RELDTTASQI LFSLQLLSEL MPQGEGTTNP HRLTDGGATY QQHMRNGSNN LRPQLAEVGH
     SKSFTEGTSS PADIVSGESS KVKRFFGEVP ATPLPGRESE DQPDYLRLDY EGEIAYDVKS
     EVPILRGGTL IALVEQLTRH DRLDSPFNNT FLLTYRSFTT APELFELLVK RWTIQPPYGL
     GGADLETWVN RKQKPIRFRV VNILKSWFDN YWMEANDEAS QQLMQRVYAF AKDTVQSTST
     PGAGPLMTAI EQRMRGQDAS SKRLVLTINS QAPQPIVPKN MKKLKFLDID ALEFARQLTI
     IESKLYGKIR PTECLNKTWQ KKLAPGEPDP ADNVKSLILH SNQLTNWVAQ MILTQADVKR
     RVVVIKHFVS IADKCRNLNN FSCLTSIISA LGSAPIHRLN RTWSQVNQRT TQTLESMRKL
     MGSTRNFNEY REALHKANPP CIPFFGIYLT DLTFIEDGIP GLIKRTQLIN FAKRAKTAEV
     IRDIQQYQNV PYGLQPVQEL QDYISNNMRS AGDVHEMYER SLQVEPRERE DEKIARLLSE
     SGFL
//

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