ID FBSP1_DROGR Reviewed; 252 AA.
AC B4J6Q0;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=F-box/SPRY domain-containing protein 1 {ECO:0000250|UniProtKB:Q9V6L9};
GN Name=Fsn {ECO:0000250|UniProtKB:Q9V6L9}; ORFNames=GH21169;
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222;
RN [1] {ECO:0000312|EMBL:EDW00953.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00 {ECO:0000312|EMBL:EDW00953.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Required in the presynaptic motoneuron to down-regulate the
CC levels of wnd and restrain synaptic terminal growth at the
CC neuromuscular junction (NMJ). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000250|UniProtKB:Q9V6L9}.
CC -!- SUBUNIT: Component of an E3 ubiquitin ligase complex composed of hiw
CC and Fsn. {ECO:0000250|UniProtKB:Q9V6L9}.
CC -!- SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q9V6L9}.
CC -!- SIMILARITY: Belongs to the FBXO45/Fsn family. {ECO:0000305}.
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DR EMBL; CH916367; EDW00953.1; -; Genomic_DNA.
DR RefSeq; XP_001986086.1; XM_001986050.1.
DR AlphaFoldDB; B4J6Q0; -.
DR SMR; B4J6Q0; -.
DR STRING; 7222.B4J6Q0; -.
DR EnsemblMetazoa; FBtr0156583; FBpp0155075; FBgn0128631.
DR GeneID; 6561060; -.
DR KEGG; dgr:6561060; -.
DR eggNOG; KOG3953; Eukaryota.
DR HOGENOM; CLU_046756_1_0_1; -.
DR InParanoid; B4J6Q0; -.
DR OMA; DACRGKI; -.
DR OrthoDB; 65989at2759; -.
DR PhylomeDB; B4J6Q0; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IEA:EnsemblMetazoa.
DR GO; GO:0031594; C:neuromuscular junction; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:EnsemblMetazoa.
DR GO; GO:0045495; C:pole plasm; IEA:EnsemblMetazoa.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IEA:EnsemblMetazoa.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:EnsemblMetazoa.
DR GO; GO:0045886; P:negative regulation of synaptic assembly at neuromuscular junction; ISS:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0007274; P:neuromuscular synaptic transmission; ISS:UniProtKB.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:EnsemblMetazoa.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd12907; SPRY_Fbox; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035784; SPRY_FBXO45.
DR PANTHER; PTHR12245:SF7; F-BOX_SPRY DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR12245; SPRY DOMAIN CONTAINING SOCS BOX PROTEIN; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
PE 3: Inferred from homology;
KW Neurogenesis; Reference proteome; Synapse; Ubl conjugation pathway.
FT CHAIN 1..252
FT /note="F-box/SPRY domain-containing protein 1"
FT /id="PRO_0000383312"
FT DOMAIN 1..48
FT /note="F-box"
FT /evidence="ECO:0000255"
FT DOMAIN 58..250
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
SQ SEQUENCE 252 AA; 28543 MW; 745E1599D9F70376 CRC64;
MVDPLCNYNV LESIFSYLEL NDLNRCSQVC KSWYHFLNDE NSDVWRWHCL RKLPKEAVKS
DLLSSVTTYK TKLRAYLHAW SPNDCSRNVY VKPNGFTLHR NPVAQSTDAA RGKIGFRHGR
HAWEVIWEGP LGTVAVIGIS TKEAALQCHG YVALLGSDDQ SWGWNLVENH LLHNGDTQGS
YPLLNNAPKY QVGERIRVIL DCDDNTLSFE KNYEFLGVAF RGLPDKKLYP TVSAVYGNTE
VSMVYLGTPL DG
//
