ID G0N6Y4_CAEBE Unreviewed; 764 AA.
AC G0N6Y4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=[histone H3]-lysine(27) N-trimethyltransferase {ECO:0000256|ARBA:ARBA00012186};
DE EC=2.1.1.356 {ECO:0000256|ARBA:ARBA00012186};
GN Name=Cbn-mes-2 {ECO:0000313|EMBL:EGT54479.1};
GN ORFNames=CAEBREN_11803 {ECO:0000313|EMBL:EGT54479.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC Evidence={ECO:0000256|ARBA:ARBA00000090};
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DR EMBL; GL379846; EGT54479.1; -; Genomic_DNA.
DR AlphaFoldDB; G0N6Y4; -.
DR STRING; 135651.G0N6Y4; -.
DR EnsemblMetazoa; CBN11803.1; CBN11803.1; WBGene00150528.
DR eggNOG; KOG1079; Eukaryota.
DR HOGENOM; CLU_014126_0_0_1; -.
DR InParanoid; G0N6Y4; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR026489; CXC_dom.
DR InterPro; IPR045318; EZH1/2-like.
DR InterPro; IPR041355; Pre-SET_CXC.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR PANTHER; PTHR45747:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR Pfam; PF18264; preSET_CXC; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51633; CXC; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 499..607
FT /note="CXC"
FT /evidence="ECO:0000259|PROSITE:PS51633"
FT DOMAIN 614..730
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 764 AA; 87539 MW; 242564EBA22D5FF6 CRC64;
MDADRKKKKA EKRTITVSNN EVDEERNSDN IKIRKNSKNP QSALDGPLGA RRVANIQSIF
TEKVDTVESI NQDVKRIQDT LMLHYEDIKK EHDDVAKEET ENNHGNWLAA PKKRNYHSEN
KRNNFGKRVH SNVNELAQKC PYSRKEGVIY LTPIHDDKGN KLPKLNKVQC VRTEVGDILP
YMNYWASIEQ TLVSDDQLRL SHLPPIEEGV SEKEFYSKLA KHFSDGIHGS SVDSSCINDW
ILYRLFRKVL PCFNDTPDAF YYAVYCLWPN KLSQRQLSFA FPNWCDLYAE NGFNLFELEH
WKKQNCLKIA ENVQNLSCYA CFNYSCIEHG FKAQFPTRLP EGTYAAVNLE VCSESNTTNS
QCSNTCWKSV DKRKLKWRTL SHQEESGGNK VEVYLDKLDM LRMSHEEGGS IVSAFVFNHN
LPFCDFAQLA INSYHGKNAE FKKCSGIYEL ILEKCQKLSE QRYNLGINSN QLSKQDRVNK
FRKDQRIQAK AKIAACSEAE RITTKAKKNK QTVDLSLVTP IVPCRHSGPC SSTTEYCACR
ENGICTYLCE CDINCPQRFP GCNCSPGQCQ SKACQCYFAN WECNPITCHN CKCDNIDEEG
LICKNFPMTR NVMKRLTVAP SKIAGNGLFI LDSAEKDEFI TEYVGERISE DEVERRGIIY
DSTHCSYIFN LSSGGAIDSH SLGNISRFAN HDKKHPTVYA KTIVVAGELR IGFFAKRQLS
PGDELLFDYS YSMEHQNAIR QVNFVHFLTR QFDEKLLWAL QKIQ
//
