ID G0NRU1_CAEBE Unreviewed; 514 AA.
AC G0NRU1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN Name=Cbn-ima-3 {ECO:0000313|EMBL:EGT36322.1};
GN ORFNames=CAEBREN_25612 {ECO:0000313|EMBL:EGT36322.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR EMBL; GL379933; EGT36322.1; -; Genomic_DNA.
DR AlphaFoldDB; G0NRU1; -.
DR STRING; 135651.G0NRU1; -.
DR EnsemblMetazoa; CBN25612.1; CBN25612.1; WBGene00164337.
DR eggNOG; KOG0166; Eukaryota.
DR HOGENOM; CLU_018084_6_0_1; -.
DR InParanoid; G0NRU1; -.
DR OMA; GGNEHIQ; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF28; IMPORTIN SUBUNIT ALPHA; 1.
DR Pfam; PF00514; Arm; 7.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 1..51
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 108..150
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 514 AA; 56069 MW; E8DFDEE219383AA0 CRC64;
MSTNRQAYYK NNAKEQIGKE KRNEEAVSIR KDKREEAISK RRNINAHIDD DSETSTTPPG
PFDANLLRLT VAAAQSSDPA EQLTAVQQAR KMLSTDRNPP IDDLIGSGIL PVLVQCLSST
DPNLQFEAAW ALTNIASGTS EQTQAVVNAG AVPLFLQLLS CGNLNVCEQS VWALGNIIGD
GPHFRDYCLE LGILQPLLQF INPEIPIGFL RNVTWVIVNL CRCKDPAPSP AVVRTILPAL
SLLIHHQDTN ILIDTVWALS YLTDGGNEHI QMVIEAQVVT HLVPLLGHVD VKVQTAALRA
VGNIVTGTDE QTQLVLDSGV LRFMPGLLAH YKEKINKEAV WFVSNITAGN QQQVQDVFDA
GIMPMIIHLL DRGDFPTQKE AAWAISNVTI SGRPNQVEQM VKLGVLRPFC AMLSCTDSQI
IQVVLDGINN ILKMAGEGAE QVTSEIEECG GLDKIENLQN HENEDIYKLA FEIIDNFFSS
DDEAGNVEGA ATNAFGGDVP PIPDAPNGGW DFGK
//
