ID G0NUG8_CAEBE Unreviewed; 494 AA.
AC G0NUG8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN ORFNames=CAEBREN_05650 {ECO:0000313|EMBL:EGT37816.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; GL379950; EGT37816.1; -; Genomic_DNA.
DR AlphaFoldDB; G0NUG8; -.
DR STRING; 135651.G0NUG8; -.
DR EnsemblMetazoa; CBN05650.1; CBN05650.1; WBGene00144375.
DR eggNOG; KOG1215; Eukaryota.
DR HOGENOM; CLU_552341_0_0_1; -.
DR InParanoid; G0NUG8; -.
DR OMA; IHHESAH; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 2.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00192; LDLa; 2.
DR SMART; SM00135; LY; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 2.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..494
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003405473"
FT TRANSMEM 439..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 390..429
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 28..40
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 47..62
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 67..79
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 74..92
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 86..101
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 400..417
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 419..428
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 494 AA; 55712 MW; 622D62CC2439E22E CRC64;
MKTSWLLLSI IVCLSKITTQ SNSPNSKCNL TEQFDCGTKC IPRTWECDNM KDCQNGADEA
DCEPSECPDG QMQCDSGGCI PGAYKCDGHN DCPDSSDEAY CGHISYRLSE NSSFNFCDPN
HYKNDGGYDK TSTLLDNYLF SVYQNEGKIS SRNFISVCTK DGRFYRRLIE IEDDRNVLGF
AIHPMRGLLF WHDSFNAVDA KKRYPYRIMM ANMDGSQVQL LIRSKSRLCK MFAIDRANNY
VYYATNDNRI RRVNIDTRKT DVVGSNLWFG SEAMAYHNGF IYWTNLYGEL EVQEMARNSS
RVHRILESGS GPFHFPHLVV NDSLHQLEPS TGNPCAELNC PWICVTVPDF TAKCLCPDGH
TPSVLGTTCV SSLPEVGDHD NLTYIGLELM SEYCKTGVGC LNGGTCRELS NKTRIVCDCL
EPYDGFYCER RKPMVSDEAV LIIVLLLLLI AIGFGIYYLF FIRRIGKKEA AEIVLSVVCL
SILDECLENN RTTD
//
