ID G0R8Q5_HYPJQ Unreviewed; 1001 AA.
AC G0R8Q5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EGR52924.1};
GN ORFNames=TRIREDRAFT_119803 {ECO:0000313|EMBL:EGR52924.1};
OS Hypocrea jecorina (strain QM6a) (Trichoderma reesei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=431241 {ECO:0000313|Proteomes:UP000008984};
RN [1] {ECO:0000313|EMBL:EGR52924.1, ECO:0000313|Proteomes:UP000008984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QM6a {ECO:0000313|EMBL:EGR52924.1,
RC ECO:0000313|Proteomes:UP000008984};
RX PubMed=18454138; DOI=10.1038/nbt1403;
RA Martinez D., Berka R.M., Henrissat B., Saloheimo M., Arvas M., Baker S.E.,
RA Chapman J., Chertkov O., Coutinho P.M., Cullen D., Danchin E.G.,
RA Grigoriev I.V., Harris P., Jackson M., Kubicek C.P., Han C.S., Ho I.,
RA Larrondo L.F., de Leon A.L., Magnuson J.K., Merino S., Misra M., Nelson B.,
RA Putnam N., Robbertse B., Salamov A.A., Schmoll M., Terry A., Thayer N.,
RA Westerholm-Parvinen A., Schoch C.L., Yao J., Barabote R., Nelson M.A.,
RA Detter C., Bruce D., Kuske C.R., Xie G., Richardson P., Rokhsar D.S.,
RA Lucas S.M., Rubin E.M., Dunn-Coleman N., Ward M., Brettin T.S.;
RT "Genome sequencing and analysis of the biomass-degrading fungus Trichoderma
RT reesei (syn. Hypocrea jecorina).";
RL Nat. Biotechnol. 26:553-560(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; GL985056; EGR52924.1; -; Genomic_DNA.
DR RefSeq; XP_006961754.1; XM_006961692.1.
DR AlphaFoldDB; G0R8Q5; -.
DR EnsemblFungi; EGR52924; EGR52924; TRIREDRAFT_119803.
DR GeneID; 18482709; -.
DR KEGG; tre:TRIREDRAFT_119803; -.
DR VEuPathDB; FungiDB:TRIREDRAFT_119803; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_002458_2_1_1; -.
DR OrthoDB; 54187at2759; -.
DR Proteomes; UP000008984; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR022257; PHM7_ext.
DR PANTHER; PTHR13018:SF53; DOMAIN PROTEIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008984};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 62..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 513..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 726..744
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 765..784
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 790..809
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..211
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 234..499
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 511..783
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 945..1000
FT /note="10TM putative phosphate transporter extracellular
FT tail"
FT /evidence="ECO:0000259|Pfam:PF12621"
FT REGION 34..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1001 AA; 111982 MW; 38845D159C99A43A CRC64;
MSLQPELRSH RQLLDMAIPW HELLVRGLTL PNDNRTGSAR DGSEGGTLST SSGNKTASLS
KLGATFAPVA IYLGLCLTCF ILLRSRSKRV YAPKTIPSLR YPENPIPELP SGLFNWIIPF
FKIPDTYILN NGSLDAYFFL RYLKVLRNIS FVGCCIVWPI LLPVHGTGGN RLQQLEFLTI
GNVITGSRKL WAHAVVAWLF FGFVLFTVVR ECIYFVNLRQ AYLSSPYYAD RLSSKTLLLL
CIPKPYRDEA ILRKLYGDSA KRIFIPRTSK DLANLVEERE QTAMRLEKAE IALIKKANAA
RNKWLKKNPQ VGNVLDNPGK LEAEAAKRNK IAALDSAETV QQSSGPLEVT SDVENQRNST
SVEASNKQVN VEEEVEVQAE DSDYVHPYGL RSTLPDVRGS VASEWLPAEA RPYHRPLGNF
GRRVDTIGWT RKRLKELNIQ IYKLRRQIKR GDAEPLPAAF IEFDTQEAAH AAQQVVVHHL
PLQMAPGLLG IRPEEVIWES LRMKWWERII RRLLILCGIT AAIIFWSIPS AFIGAVSNMD
FLTKEIPFLH WLDKLPSFVK GVIGGFIPPF ALSVLMALVP ILLRICAAQT GIPSLIIGEL
FTQNAYFAFQ VVQVFLVTTI TSAASGALQD IIQDPLSIQS LLAQNLPKAS NFYLSYILIQ
CLASGGSQLL QVFSLIRHHI VAKASDVPRT RFRTWRNVRP ARWGGIFPVF TNMGVITLSY
ACIAPLILVF SAGGMAFMAA VWKYNLLYVF DTTTDSKGLF YPRALQQLII GLYLAEICLI
GLLILNSAYG PMGCVIALLL LTGLIHFLLR DAISRLMWSL PQTLALEEQI QQEAKAKLAD
HDDGVTPGND AVGAAASYFD VEQAFGDEEE KIDDDEEDDH QVVSNRAIEG ATSIRQALTA
WMKSAAIEKV KTGMEDSGLN AILAKVFAFA RSGNGEEPPG FLVRWLHPEE HEDFVALRKL
IIQEDRPPIV YTNENKYATY QPPELWMPKP TLWIPRDEAR T
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