ID G0RMV0_HYPJQ Unreviewed; 795 AA.
AC G0RMV0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EGR47433.1};
GN ORFNames=TRIREDRAFT_64193 {ECO:0000313|EMBL:EGR47433.1};
OS Hypocrea jecorina (strain QM6a) (Trichoderma reesei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=431241 {ECO:0000313|Proteomes:UP000008984};
RN [1] {ECO:0000313|EMBL:EGR47433.1, ECO:0000313|Proteomes:UP000008984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QM6a {ECO:0000313|EMBL:EGR47433.1,
RC ECO:0000313|Proteomes:UP000008984};
RX PubMed=18454138; DOI=10.1038/nbt1403;
RA Martinez D., Berka R.M., Henrissat B., Saloheimo M., Arvas M., Baker S.E.,
RA Chapman J., Chertkov O., Coutinho P.M., Cullen D., Danchin E.G.,
RA Grigoriev I.V., Harris P., Jackson M., Kubicek C.P., Han C.S., Ho I.,
RA Larrondo L.F., de Leon A.L., Magnuson J.K., Merino S., Misra M., Nelson B.,
RA Putnam N., Robbertse B., Salamov A.A., Schmoll M., Terry A., Thayer N.,
RA Westerholm-Parvinen A., Schoch C.L., Yao J., Barabote R., Nelson M.A.,
RA Detter C., Bruce D., Kuske C.R., Xie G., Richardson P., Rokhsar D.S.,
RA Lucas S.M., Rubin E.M., Dunn-Coleman N., Ward M., Brettin T.S.;
RT "Genome sequencing and analysis of the biomass-degrading fungus Trichoderma
RT reesei (syn. Hypocrea jecorina).";
RL Nat. Biotechnol. 26:553-560(2008).
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR EMBL; GL985068; EGR47433.1; -; Genomic_DNA.
DR RefSeq; XP_006966561.1; XM_006966499.1.
DR AlphaFoldDB; G0RMV0; -.
DR EnsemblFungi; EGR47433; EGR47433; TRIREDRAFT_64193.
DR GeneID; 18487138; -.
DR KEGG; tre:TRIREDRAFT_64193; -.
DR VEuPathDB; FungiDB:TRIREDRAFT_64193; -.
DR eggNOG; KOG2195; Eukaryota.
DR HOGENOM; CLU_005688_2_0_1; -.
DR OrthoDB; 67337at2759; -.
DR Proteomes; UP000008984; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008984};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 198..274
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 393..579
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 669..794
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
FT REGION 58..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..75
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 795 AA; 87523 MW; AA63D2EC814FD170 CRC64;
MANESTPLIQ TVRVGPPRRR YRHHTLRRFC NIACVSLLLC GFASFALHSL YIWPSGQEHR
HRHPHHPHHG HPDHGHKHLS HEDLQAILLD TPSSEKAEEW SRYYTSGAHL AGKNYSQAEW
TKDRWEEWGV KSSIVAYDVY INYPIDHSVS LLEKSSDAKS WNVAFKASLT EDVLEEDPTT
AAKDKIPTFH GYSASGNVTG SFVYVNYGTY RDFADLVEAG IDLEGKIAIA RYGGIFRGLK
VKRAQELGMI GVLIYSDPGD DGEITEENGY AAYPEGPARN PSSVQRGSVQ FLSSRPGDPT
TPGYPSKPGV PRAPADETTP SIPSIPISYA DALPLLKALN GHGPRASDLN KWWNRKLGLG
YKGVDYNIGP SPEDVVINLY NEQDYVIAPQ WDVIGIINGT IPNEVIIVGN HRDAWIVGGA
SDPNSGSSVL NEAVRSIGKA LEAGWKPLRT IVFASWDGEE YGLIGSTEWV EEYLPWITDA
NVAYVNVDGG ASGPQFSAAA APLLNQVLRD ATHLVPSPNQ TVAGQTVGDV WDGKISTMGS
GSDFTAFQDY AGIPSLDMGF GGNGSGPVYH YHSNYDSFHW MSEYADPGFV YHRTMAQVLA
VLVGELADRV VIPFGATEYA DALDSYLDKV EAKLQPADAD LATDDEIFAV RGSVSSHEVI
GSQDAFEESL KKIRHSISEF RDKAVKLDER AAWAKKKLEE GLPWWNIIGK ARLGLTIIRV
NHQYKYIERQ FVFEGGLDNR SWFKHVVFAP GLWTGYAGAV YPGLVESIDA KNYSNGLKWA
GIIKHAVDKA TKSIQ
//
