ID G0S6V1_CHATD Unreviewed; 3382 AA.
AC G0S6V1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=MPN domain-containing protein {ECO:0000259|PROSITE:PS50249};
GN ORFNames=CTHT_0026970 {ECO:0000313|EMBL:EGS20859.1};
OS Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
OS (Thermochaetoides thermophila).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Thermochaetoides.
OX NCBI_TaxID=759272 {ECO:0000313|Proteomes:UP000008066};
RN [1] {ECO:0000313|EMBL:EGS20859.1, ECO:0000313|Proteomes:UP000008066}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1495 / CBS 144.50 / IMI 039719
RC {ECO:0000313|Proteomes:UP000008066};
RX PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA Arumugam M., Bork P., Hurt E.;
RT "Insight into structure and assembly of the nuclear pore complex by
RT utilizing the genome of a eukaryotic thermophile.";
RL Cell 146:277-289(2011).
CC -!- SUBUNIT: Component of the COP9 signalosome (CSN) complex.
CC {ECO:0000256|ARBA:ARBA00011098}.
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DR EMBL; GL988041; EGS20859.1; -; Genomic_DNA.
DR RefSeq; XP_006693155.1; XM_006693092.1.
DR STRING; 759272.G0S6V1; -.
DR MEROPS; M67.A02; -.
DR GeneID; 18256735; -.
DR KEGG; cthr:CTHT_0026970; -.
DR eggNOG; KOG1554; Eukaryota.
DR eggNOG; KOG1910; Eukaryota.
DR HOGENOM; CLU_000592_0_0_1; -.
DR OMA; FKKVIMK; -.
DR OrthoDB; 607689at2759; -.
DR Proteomes; UP000008066; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR CDD; cd08069; MPN_RPN11_CSN5; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR InterPro; IPR019443; BLTP2/FMP27/Hobbit_C.
DR InterPro; IPR040961; CSN5_C.
DR InterPro; IPR019441; FMP27/BLTP2/Hobbit_GFWDK_RBG.
DR InterPro; IPR019439; FMP27/BLTP2_N.
DR InterPro; IPR019409; FMP27_sixth_RBG.
DR InterPro; IPR019415; FMP27_SW_RBG.
DR InterPro; IPR019449; FMP27_WPPW_RBG.
DR InterPro; IPR045167; Hobbit.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR PANTHER; PTHR15678; ANTIGEN MLAA-22-RELATED; 1.
DR PANTHER; PTHR15678:SF6; PROTEIN KIAA0100; 1.
DR Pfam; PF18323; CSN5_C; 1.
DR Pfam; PF10293; DUF2405; 1.
DR Pfam; PF10351; FMP27-BLTP2_C; 1.
DR Pfam; PF10344; FMP27-BLTP2_N; 1.
DR Pfam; PF10347; Fmp27_GFWDK; 1.
DR Pfam; PF10305; Fmp27_SW; 1.
DR Pfam; PF10359; Fmp27_WPPW; 1.
DR Pfam; PF01398; JAB; 1.
DR SMART; SM01214; Fmp27_GFWDK; 1.
DR SMART; SM01215; Fmp27_SW; 1.
DR SMART; SM01216; Fmp27_WPPW; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR SUPFAM; SSF102712; JAB1/MPN domain; 1.
DR PROSITE; PS50249; MPN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008066};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3082..3218
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
FT REGION 106..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1090..1127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2023..2052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2758..2777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2787..2998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1859..1886
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2023..2047
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2761..2777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2787..2876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2883..2967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3382 AA; 379717 MW; 7823A761BD5DA68A CRC64;
MALLDPTFFL GVLVLLYLLS FVLFAVVRIT TGLSIQRIGY FSLRRIAYSP RDGVRIEIRG
LGLNLHRPTF AQPTWLSIVV DELSVSLDLA ELEKARARAI AAEDGLDSDS DVPTPAPVRP
TTPKTTPKIQ RDAAPEERSK TWERLTNIKE RLKRIHRKVN WLRMVDLVAT NSTVALAGVG
SLQMGSFTIA IDTRRKTVDR ARFFLQGRAR KLREAQQAEW IVTLRSVLFT ADGREPLEII
DSATLNIHGY LYEALDGLRD AAIALKIGRL HIPYDDVLHS LSQYRKIRPR PSQQSVELGP
AEHVTIDRII QEVDAPGSST NHALMQTVSD SKEFVSSILR GIKEVQFAIS FIGFTKKIES
VKPAGSPVLL TASMKEVGID LHRLDPKSPA HRMYFTSNDI AHEALAAALS ISVGLDDGHG
KPERIMYIPM ATTTARTTLP SKTVELANEG TAEQRNANIL FANSVVTSPS VDLDPRHLPL
LMAMLQRKPR PPKAQQHEQK HMLISRLLPK ANIKFSMHEP VLRITLPPVQ PSSDSEDFDL
IISSISSVSL DMESFHSAVE ELHYSLAATM RLQTHNLYYQ TCTGTRFDLL QTESFDLKVQ
LSASPNLHVV ASGNLQTFTV KMIQAEIRNG LRQIVQQMRP NVVEPDKHPF TPPAPKQSNF
LRGLPSWLLH FHLQCSDCSF EVAGVDKDIS EEQRGVAVQL ESWSADYQAQ RFDGLQRRPS
HSRRRASSRG MMSPESDLLA AYSGSSPKKK YHHEGDGRRL TFMVRGLEAF MIESSEKWEF
EPFISIPKLD VTLATLSDNQ GPLFHVYTYL RSLLVQYSLY RHYAVGVAIA TLQNAFLRRR
KPTVDLMTPP TSPTSPLSPQ RRIIGHLSPP SSGNYPSPSD IESWRAVPEL VTVDFRSTLI
QIKAEMPSDP PMMFHVYNLE AGRHRWAPPF LQAKLVRLYA EAPRMRRVWA KLVSVKNLRA
DYRESRHRYA GGGVREERMF DVVTETIRLA VPHDLIIYKV TDNFVNTFKS VQQLHHRFKT
GTNEYILDKG PEPPKKVPKV SLRAKNLLFE LEDGAFEWKL GVIYRTGLVE MMQRQAREEA
FRLKVKKIHE EEAKRGSTKS RARSTAPHGE SSMPGDPHVR SRSADGRRRS FSTIYMRGRI
PRYDPEAGAH GLSGKARISI AEARHQLDLH NAKSWKQRID RAYEMSKAAA KEHYAQFWGI
NEIPDDLEDS EKILEVPQRP ALMSTLINDL HIVIDKPSFP LKELPDFLHK VGKGMPKDMK
YTLLIPMNLQ VNMGEARISL RDYPLPFLHV PATKSEQSAR LPALALSTDF VIAEEYRGLE
STRKIRVPII PPRDLDGLSP NEGGFAIEVR RTIGPVKTFS DMNVDIHTAN PTRITWGPSY
QPAIQDMMMA IESMTKPQLD PSEKVGFWDK IRLNFHSRIR VAWRGDGDVH LALKGSRDPY
QVTGNGAGFL MCWRGDVRWN IWTEDDPKRF MTVDSGEYVL AVPDYSQQVR EVRRQRGEDE
SIASNDSFRS GAAFKKVVMK LSGKVQWLAG LVFERAIENG TRSFEFKPHY EIVLKNPEYA
RPQQDGLPYD AFRGFRSQHI HLSLAVLAPA DRDWTGSNSE PSRSYNTAHL TPRLFTHFFS
WWSLFSGPLS SLPIRQGTLW PGREKNSKKF GRHLATIKYN VCLAPLFLSH IYKHKDAEDY
SENSISATGI KVRFDSAILD LHQRREEFNT RDRGRKTQVR TTGMKIHAGQ LDLVSADVRA
ISASIRGTTA DAVMRQSLST FITDQEGDGT DLSRFTVPDN DLTWIDMDDF VELDWILPTE
PNPDTKILPL AFAPRVTYFR QTDINGIIDG DPDRTSPFGQ EPTHFCVMSH DDDPRIVQSQ
LIRRRLEQLE EQMAAHDRTL GEIDLRIARG EEDLRAESEL LSHHTSVLKD KKTFLESMLT
KLRVGSGSCN NDAASCSSAG LNGSSSSSFR GSLETSAVAE FASDFKNRFV VHNLQLKWNN
TLRNIILRYI HQVGQRRGFV YYMSRPAVKF ILDLVEEQQQ AKSNAIKNGG SSVASGTGST
LDGSGSNQDA EKDLEDRIRR ILQDSRKFVA PDDDDVVANN PAMVDLSAGI ADEFTTQNSY
HVRLIAPQIQ LQSDKNKKHV VLCASKGMEL KVVDVLDKSR MFDEVSGLVQ RRFLVNMDST
QFFVTHQKWF STQLVSMYSG NTYGAPVGSA WPPWVPMEVM FDFESDPFGF KRVVQKTSAM
LRYDKFNTLR LKYNDEINTS ENGGVPLLDS DESRTDNLWV IFPKAHAMCN SQQYYAIYII
VLDLLMYSEP LEKTRNERLE KIMLASDFSD LRGAPEMVIK LQERVRQLEE IKTHFQVHSK
NLDKKGWKDR LVLERDLAAC EDELFFLMKA ITTSQRKYDN RTSSAMLKWS IMAKEIVWRL
LRDNNEPLVE LQLKNVEYNR VDNSDGSHIN LVQVGKILGF NLLDNAIYPA MIAPYTDDMT
AFDTGSQPMI RVYWNMLEAI AGIPVMDHFE VNLYPLKVQL EREVGKKLFE YIFPGTDGGK
VPGKNESPLI IKHSPSGDEE TEADDDSLAE SVHYLQDHDD DAFSTRAGSL ELRLRPTLTS
DPDETSLKQQ ALSVHSGEGT SFRLLRVGTG FKAAISKKRS FDSLRMSTSQ PGVGRSATST
SIKDAVSIAS ESKKGSRFIL RHRTTDLDKP KQSDDLSMMM DRASNYMTFA YIKMPSVVLC
LSYKGKGERN FEDVHDFVFR LPTIEWRNKT WSNLDLALAL KSRVIKALIS HTGAIIGNKF
SKHRPNTTQQ SKMRELASNS VLLATPTSSE AREASGDDSS SIYGPSPVDF SRSPPQSIRR
SHTTSVPVPS SSRSSSVASS MRSQQSITQY PAQQQQQSQQ HTAHVSVTSQ ATGAIPSFLM
APSLTGSPES GTSSNNNNRS SGGNGSGFSL LRPTSSGWSR AFGGGRQQHQ QESSGEGLFF
SSRSRPSSRP GSSSGVPVLS SSPRQIGYLS DDEGFGGNRS ADRMQRPRGK TILPSPGLLL
DPSITRQPAV SKTYNFTFTS SPLISFAADH FAAVNTKIME LPITDKLVDR QRDALYNYDP
NSQKDINVKR PWDQDPTYFK TVRVSSVALT KMVMHAREGG SIEVMGMMQG YVDGTTIVVT
DAFRLPVEGT ETRVNAQGEA DEYLVNYLDL CRKESRLENI VGWYHSHPGY GCWLSGIDVE
TQKLQQLQGP MVAVVIDPNR TVSANKVEIG AFRTYPDWYT PPDQSGSTTG GSGPAGASTT
VPLSKTMDYG AHANKYYRLE VEHFKSTLDT RLLDLLWNKY WVQTLAQNPL LSNRDYSSSN
MDDVGQRLQE IAVNVSRMGK GMLHYHYLGS SSSLGGVNTN GPKAVDQSIE KAVQDVGQIA
AKERAGLLAA EVKVQIFGQG EV
//