ID G0S9T3_CHATD Unreviewed; 2898 AA.
AC G0S9T3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Ribosomal protein L19 {ECO:0000256|RuleBase:RU000574};
GN ORFNames=CTHT_0047080 {ECO:0000313|EMBL:EGS20194.1};
OS Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
OS (Thermochaetoides thermophila).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Thermochaetoides.
OX NCBI_TaxID=759272 {ECO:0000313|Proteomes:UP000008066};
RN [1] {ECO:0000313|EMBL:EGS20194.1, ECO:0000313|Proteomes:UP000008066}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1495 / CBS 144.50 / IMI 039719
RC {ECO:0000313|Proteomes:UP000008066};
RX PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA Arumugam M., Bork P., Hurt E.;
RT "Insight into structure and assembly of the nuclear pore complex by
RT utilizing the genome of a eukaryotic thermophile.";
RL Cell 146:277-289(2011).
RN [2] {ECO:0007829|PDB:7OLC, ECO:0007829|PDB:7OLD}
RP STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS) OF 2707-2898.
RX PubMed=35079002; DOI=10.1038/s41467-022-27967-9;
RA Kisonaite M., Wild K., Lapouge K., Ruppert T., Sinning I.;
RT "High-resolution structures of a thermophilic eukaryotic 80S ribosome
RT reveal atomistic details of translocation.";
RL Nat. Commun. 13:476-476(2022).
RN [3] {ECO:0007829|PDB:8I9X, ECO:0007829|PDB:8I9Y}
RP STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS).
RX PubMed=37129998; DOI=10.15252/embr.202356910;
RA Lau B., Huang Z., Kellner N., Niu S., Berninghausen O., Beckmann R.,
RA Hurt E., Cheng J.;
RT "Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation
RT during pre-60S biogenesis.";
RL EMBO Rep. 24:e56910-e56910(2023).
RN [4] {ECO:0007829|PDB:8PV1, ECO:0007829|PDB:8PV2}
RP STRUCTURE BY ELECTRON MICROSCOPY (2.12 ANGSTROMS).
RX PubMed=37921038; DOI=10.15252/embr.202357984;
RA Thoms M., Lau B., Cheng J., Fromm L., Denk T., Kellner N., Flemming D.,
RA Fischer P., Falquet L., Berninghausen O., Beckmann R., Hurt E.;
RT "Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA
RT processing during ribosome formation.";
RL EMBO Rep. 0:e57984-e57984(2023).
RN [5] {ECO:0007829|PDB:7Z3N, ECO:0007829|PDB:7Z3O}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS) OF 2707-2898.
RX PubMed=37081320; DOI=10.1038/s41594-023-00973-1;
RA Kisonaite M., Wild K., Lapouge K., Gese G.V., Kellner N., Hurt E.,
RA Sinning I.;
RT "Structural inventory of cotranslational protein folding by the eukaryotic
RT RAC complex.";
RL Nat. Struct. Mol. Biol. 30:670-677(2023).
CC -!- SIMILARITY: Belongs to the GCN1 family.
CC {ECO:0000256|ARBA:ARBA00007366}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL19 family.
CC {ECO:0000256|ARBA:ARBA00011082, ECO:0000256|RuleBase:RU000574}.
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DR EMBL; GL988043; EGS20194.1; -; Genomic_DNA.
DR RefSeq; XP_006695079.1; XM_006695016.1.
DR PDB; 7OLC; EM; 2.90 A; LR=2707-2898.
DR PDB; 7OLD; EM; 3.00 A; LR=2707-2898.
DR PDB; 7Z3N; EM; 3.20 A; LR=2707-2898.
DR PDB; 7Z3O; EM; 3.30 A; LR=2707-2898.
DR PDB; 8I9X; EM; 2.80 A; LR=1-2898.
DR PDB; 8I9Y; EM; 3.10 A; LR=1-2898.
DR PDB; 8I9Z; EM; 2.70 A; LR=1-2898.
DR PDB; 8IA0; EM; 2.70 A; LR=1-2898.
DR PDB; 8PV1; EM; 2.56 A; LR=1-2898.
DR PDB; 8PV2; EM; 2.63 A; LR=1-2898.
DR PDB; 8PV3; EM; 2.80 A; LR=1-2898.
DR PDB; 8PV4; EM; 2.90 A; LR=1-2898.
DR PDB; 8PV5; EM; 2.86 A; LR=1-2898.
DR PDB; 8PV6; EM; 2.94 A; LR=1-2898.
DR PDB; 8PV7; EM; 2.12 A; LR=1-2898.
DR EMDB; EMD-12976; -.
DR EMDB; EMD-12977; -.
DR EMDB; EMD-17950; -.
DR EMDB; EMD-17951; -.
DR EMDB; EMD-17952; -.
DR EMDB; EMD-17953; -.
DR EMDB; EMD-17954; -.
DR EMDB; EMD-17955; -.
DR EMDB; EMD-17956; -.
DR EMDB; EMD-35287; -.
DR EMDB; EMD-35288; -.
DR EMDB; EMD-35289; -.
DR EMDB; EMD-35290; -.
DR SMR; G0S9T3; -.
DR STRING; 759272.G0S9T3; -.
DR GeneID; 18258746; -.
DR KEGG; cthr:CTHT_0047080; -.
DR eggNOG; KOG1242; Eukaryota.
DR eggNOG; KOG1696; Eukaryota.
DR HOGENOM; CLU_000504_1_1_1; -.
DR OMA; KYATQRG; -.
DR OrthoDB; 6844at2759; -.
DR Proteomes; UP000008066; Unassembled WGS sequence.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR CDD; cd01417; Ribosomal_L19e_E; 1.
DR Gene3D; 1.10.1200.240; -; 1.
DR Gene3D; 1.10.1650.10; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 5.
DR HAMAP; MF_01475; Ribosomal_L19e; 1.
DR InterPro; IPR035970; 60S_ribosomal_eL19_sf.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR022716; Gcn1_N.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR019399; Parkin_co-regulated_protein.
DR InterPro; IPR004155; PBS_lyase_HEAT.
DR InterPro; IPR023638; Ribosomal_eL19_CS.
DR InterPro; IPR000196; Ribosomal_eL19_dom.
DR InterPro; IPR015972; Ribosomal_eL19_dom1.
DR InterPro; IPR033935; Ribosomal_eL19_euk.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR23346:SF7; EIF-2-ALPHA KINASE ACTIVATOR GCN1; 1.
DR PANTHER; PTHR23346; TRANSLATIONAL ACTIVATOR GCN1-RELATED; 1.
DR Pfam; PF21040; CEP104-like_TOG; 1.
DR Pfam; PF12074; Gcn1_N; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF10274; ParcG; 1.
DR Pfam; PF01280; Ribosomal_L19e; 1.
DR SMART; SM00567; EZ_HEAT; 6.
DR SMART; SM01416; Ribosomal_L19e; 1.
DR SMART; SM01349; TOG; 2.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF48140; Ribosomal protein L19 (L19e); 1.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
DR PROSITE; PS00526; RIBOSOMAL_L19E; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:7OLC, ECO:0007829|PDB:7OLD};
KW Reference proteome {ECO:0000313|Proteomes:UP000008066};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW ECO:0000256|RuleBase:RU000574};
KW Ribosomal protein {ECO:0000256|ARBA:ARBA00022980,
KW ECO:0000256|RuleBase:RU000574}.
FT DOMAIN 1344..1580
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 1521..1559
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 1664..1881
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 1984..2021
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 2709..2852
FT /note="Large ribosomal subunit protein eL19"
FT /evidence="ECO:0000259|SMART:SM01416"
FT REGION 2671..2692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2855..2898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2898 AA; 316680 MW; 5026D8B5578C6E93 CRC64;
MSEPVANDAA PGSFDLEQAR TALTSSSTTV RIAQLRAIDE KISHNSLDRP ALLGLLKVLF
WTHTFYADRP SRRAVQKCLT SITKCSEAES FVPPLVAAIR QEAQKQAIAQ ANSFALVEWC
SLLIQNLAGT SLWEKCSKDL VLATADALEK SLQPTARGSV GHSALVITRR GFRKLVQADQ
AAVSTAIGVL AAKDAKPTAK NSVLLGVIAG VCARQPEAKA VVEDLKGQYF TFYAREIIGS
RTALPSHIAD GLHDFFAAFV SLEDLDKEVF PAIEKGLLRA PEVVLNDLIT PLVKALPKLD
LSKALNSRFV KPLLSNIKSS NAVIRSGAVR AFREIATVCR DFADLEKTAD EVLGPLKTNK
LASADHRVLH SEMLSGLPLS ASIATKIATG LPAVTSKEAN EAALSAETLA LNASALFLLR
TPEVPKALLD AYVKGLGDKK VSSRRIWILR TGDLLQAFAQ EAELPAGFVA FAEAVVPSLL
TIFNEVVANP TAAVQSGLVT GALVVAGLSG LLQRLENANI QALLKKAAVQ KNSLILDPKP
SFVLSQRLYS KYPEDDLKWF CRALSAIVEG LLSSSDAIKL AWTQAFIFLI CSATTPSAVR
RQAIDALSDL SARSLKPGCQ FVATEIIKGL WHWIATSEAA EKESAAVLAK SGTSNLHLVL
KAICLSPAEL NRRSGGDVDK AQLQAQMCSL LVLAKQQLIP RASWIDLCLK VQVDPGQLAK
DHEDALIDEI VRCTGHEQKS EATKQAAYSA AAELVFVSPE NMTSRIVALI QDDLDAAVVS
TVGPLEAAIF RTPEGTTFVD VLAKRQNVVP NKNVKDYDLL KWEEELRQQL AEKKGIQKKL
TAEEQAKVSA QLKKEAEIRE NVRKIAAKLL RGFGVVKALA TGPPTDATRW MGAAVSSTLA
AINAGATRIT GETGPLAFVS LSEQITSRIG SFIRPFMGVA TLRAYEVTAL PENLTEEPFE
ELITRVLYRL RFVGEQRPLD TVSLIYVLPL VLYVLEKGGF AKDADEKDAQ LVLAIEILSF
HTDVAFDEAL PRAEILSSLI SSMQKYSQHY KILKDCFSDM VRCIAPNISP AEIGVLARGA
IVPQTSVRTA VLQAISADVD MSDVNASEEI WLACHDDIDE NAELGREIWE ESEWKTSEEL
GHKMIPYLES KDVQLRRAAA KSLAEVAGQH PDVVAPILEK LRESYVELAK PRVQQLDEFG
MPKKMDLSDP WEARHGIALA FKGLAPHLEK RQLEPYFNFL IEQGPLGDQS AGVRAEMLEA
ANMTIEIHGK EILDRLMKTF EKVLEAPDKN SEAADRVNEA VIIMYGALAR HLKPGDKKIP
VVIERLLATL STPSEAVQYA IAECLPPLVR TCADKSSKYF DEMMEILLTS KKYSEQRGAA
YGLAGLVLGR GINVLKEYRI MTQLNSALEN KKEIRQRESA MIAYELLSTI LGRLFEPYVI
QIVPQLLAGF GDGNADVREA ALAAAKACFA KLSSYGVKQI LPTLLNGLDD DQWRSKKGAC
DLLGAMAYLD PQQLAQNLPE IIPPLTAVLN DSHKEVRAAA NRSLKRFGEV ITNPEIKSLI
DILLKALSDP TKYTDDALDA LIKVQFVHYL DAPSLALVSR ILQRGLGDRS NTKRKASQVI
GSLAHLTERK DLIAHLPVLV AGLKVAVVDP VPTTRATASR ALGSLVEKLG EDALPDLIPN
LMQTLKSDTS AGDRLGSAQA LSEVLAGLGT SRLEETLPTI LQNVESPKPA VREGFMSLFI
FLPVCFGNSF ANYLGKIIPP ILSGLADDVE SIRETALRAG RLLVKNFAVR AVDLLLPELE
RGLADDNYRI RLSSVELVGD LLFNLAGVKA SANKEEDEAD QDITKEAGAS LREVLGEEKR
NKILSALYVC RCDTAGAVRA AAVTVWKQLV HSPRTLKELV PTLTQLLIKR LGSSNMEHKV
IASNALGELI KKAGDGVLAT LLPTLEEGLQ TSRDVNAKQG ICLALKELIS SASPEALEDH
EKTLISVVRT ALTDSDSDVR EAAAEAFDSL QQIIGKRAID QVLPFLLNLL RSEEEANNAL
AALLTLLTEP TRANIILPNL IPTLITPPIS AFNAKALASL SKVAGAAMNR RLPNIINSLM
DNIVGCADET LREELDTSFD TVILSIDDTD GLNVVMNVLL QLIKHEDHRK RAATGRHLAK
FFSAATVNYS RYNQDIIRAL LISFDDKDME VVKASWNALN EFTKRLKKEE MEGLVISTRQ
TLLQVGVAGR ELAGFELPKG INAILPIFLQ GLMNGTAEQR VAAALGISDI VDRTTEASLK
PFVTQITGPL IRVVSERSTE VRSAILLTLN HLLEKMPTAL KPFLPQLQRT FAKSLADTSS
EILRSRAARA LGTLIKYTPR VDPLIAELVT GSKTTDAGVK TAMLKALYEV ISKAGSNMGE
SSRAAVLGLI DMEPDENDKA MTITNAKLFG ALMKNVPADM AVGLLKNRVM VREFTTSSVL
ALNAVLLESP SSLLDSPLAE DLPELLCQGI ESKDAFIADN FIMATGKYLL HDSPKAFETT
KAIFTSLAKL IPPGNPGDSR RLSLVLVRTM ARKQPDMVRP HLSLLAPPIF SSVRDMVIPV
KLAAEAAFVQ LFAVADEESK VFDKWITAAT DLAPNVKRSM QDYFKRVTLR LGAQARERRE
AEGGAGTLGL SADEVEDEKE LMAVGKPRVS WNRNPEKLKK PRAQSEVDPG PVPLKTVARA
RQKSFKMVNL RTQKRLAASV LGCGEGKVWL DPNEVSEISN ANSRQSIRKL VADGLIIKKP
VTMHSRSRAR ELNLARRIGR HRGFGKRKGT ADARMPQQVL WMRRQRVLRR LLVKYRASGK
IDKHLYHELY HLAKGNTFKH KRALVEHIHR AKAEKARERQ IKEEMDAKRA RTKAARERKQ
ERQAAKRNAL LGEEEESK
//
