ID   G0SCS2_CHATD            Unreviewed;       832 AA.
AC   G0SCS2;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Multiple RNA-binding domain-containing protein 1 {ECO:0000256|ARBA:ARBA00013428};
GN   ORFNames=CTHT_0058230 {ECO:0000313|EMBL:EGS19198.1};
OS   Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
OS   (Thermochaetoides thermophila).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Thermochaetoides.
OX   NCBI_TaxID=759272 {ECO:0000313|Proteomes:UP000008066};
RN   [1] {ECO:0000313|EMBL:EGS19198.1, ECO:0000313|Proteomes:UP000008066}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1495 / CBS 144.50 / IMI 039719
RC   {ECO:0000313|Proteomes:UP000008066};
RX   PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA   Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA   Arumugam M., Bork P., Hurt E.;
RT   "Insight into structure and assembly of the nuclear pore complex by
RT   utilizing the genome of a eukaryotic thermophile.";
RL   Cell 146:277-289(2011).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the RRM MRD1 family.
CC       {ECO:0000256|ARBA:ARBA00008033}.
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DR   EMBL; GL988045; EGS19198.1; -; Genomic_DNA.
DR   RefSeq; XP_006696143.1; XM_006696080.1.
DR   AlphaFoldDB; G0SCS2; -.
DR   STRING; 759272.G0SCS2; -.
DR   GeneID; 18259861; -.
DR   KEGG; cthr:CTHT_0058230; -.
DR   eggNOG; KOG0110; Eukaryota.
DR   HOGENOM; CLU_008479_0_0_1; -.
DR   OMA; EFRTKEQ; -.
DR   OrthoDB; 5477987at2759; -.
DR   Proteomes; UP000008066; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   CDD; cd12568; RRM3_MRD1; 1.
DR   CDD; cd12320; RRM6_RBM19_RRM5_MRD1; 1.
DR   Gene3D; 3.30.70.330; -; 5.
DR   InterPro; IPR034482; Mrd1_RRM3.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR23003:SF3; FI21236P1; 1.
DR   PANTHER; PTHR23003; RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN; 1.
DR   Pfam; PF00076; RRM_1; 5.
DR   SMART; SM00360; RRM; 5.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
DR   PROSITE; PS50102; RRM; 5.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008066};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW   ProRule:PRU00176}.
FT   DOMAIN          4..77
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          310..386
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          491..562
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          603..686
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          708..785
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   REGION          82..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          205..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..152
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        209..223
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   832 AA;  91376 MW;  1707EE3F046A26F9 CRC64;
     MQSSRIFVKN LPPNITESDF RKHFAVQGRQ VTDVKLYPSR RIGFIGYKSA EDAAWAVKYF
     NKTFIRLSRI AVDLAKPIAD SIPKNGAKLT PANGSARISL HNAPASGIGQ AEDGNSKKRK
     REEPAEEADP KLREFLEVMG HTSKKLRDQD VPSAEPQSEP VATVAGGESD DEYDDVAVRK
     KSQSDNTVGH SMPSAARAVT AELPIGAPPP EELKVPVPPP VPADTTDDDW LRSRTNRLLD
     LVDPDDPQFP IRPVSSMPAA ATALKAEEHP PGENAVLLKP DKAGDASVKD KAAEQHGSME
     DAIATINKTR RLFLRNLSYT TTEDDLREHF SRFGALEEVN LPLDNQNRSK GFAMIRFEKP
     EAAVAAFQLD GSTFQGRLLH ILPAAPKREF KLDEFALSKL PLKKQLLLKK KAEAASSTFN
     WNSLFMSQDA VNTAVAERLG ISKHELLDPT DASAAVKQAI AETSVIQEAK TYFAKHGVNI
     EAFKNQQRGD TVILVKNIKN TTAEELRDLF AEHGSVLRVL MPPSGTIAIV QFAQPAACRA
     AFAKKAYSRF KDSVLFLEKG PKGLFTDTPP LQQGNQTTGV QKLSAAELLA RDDAEEESTV
     ETSSLYVRNL NFSTTSEGLA NAFKHLDGFV SATVKTKPDP KKPGQVLSMG FGFCVFRTKE
     QAQAALKAMD GTVLDGYKLV IKASHRGLDA AEERRREDLA KKAAVVKRKI VIKNLPFQAT
     KKDIRDLFGT YGKLVAVRVP KKFNSQSRGF AFAEFATAKE ALNALTALKD THLLGRRLVL
     DFAEADEVDP EEQIKAMEKK TRDQLNKVTL QQLTGGGRKK INIGGDHDED ER
//